| 2010-12-11 | TranmerevLeyton OrientLeague One · England | 1–2 | League One · England |
| 2010-12-11 | EvertonvWiganPremier League · England | 0–0 | Premier League · England |
| 2010-12-11 | AtalantavAlbinoleffeSerie B · Italy | 3–1 | Serie B · Italy |
| 2010-12-11 | AuxerrevMarseilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-12-11 | Las PalmasvXerezLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2010-12-11 | BournemouthvHartlepoolLeague One · England | 0–1 | League One · England |
| 2010-12-11 | ValenciennesvParis SGLigue 1 · France | 1–2 | Ligue 1 · France |
| 2010-12-11 | CaenvNiceLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-12-11 | WesterlovGerminalPro League · Belgium | 1–1 | Pro League · Belgium |
| 2010-12-11 | HeartsvAberdeenPremiership · Scotland | 5–0 | Premiership · Scotland |
| 2010-12-11 | HamburgvLeverkusenBundesliga · Germany | 2–4 | Bundesliga · Germany |
| 2010-12-11 | NijmegenvWillem IIEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2010-12-11 | GironavCeltaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-12-11 | Aston VillavWest BromPremier League · England | 2–1 | Premier League · England |
| 2010-12-11 | BurtonvSouthendLeague Two · England | 3–1 | League Two · England |
| 2010-12-11 | FulhamvSunderlandPremier League · England | 0–0 | Premier League · England |
| 2010-12-11 | WycombevBuryLeague Two · England | 1–0 | League Two · England |
| 2010-12-11 | UdinesevFiorentinaSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-12-11 | MontrosevElginLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2010-12-11 | SevillavAlmeriaLa Liga · Spain | 1–3 | La Liga · Spain |
| 2010-12-11 | GentvCharleroiPro League · Belgium | 2–1 | Pro League · Belgium |
| 2010-12-11 | MacclesfieldvGillinghamLeague Two · England | 2–4 | League Two · England |
| 2010-12-11 | DortmundvWerder BremenBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2010-12-11 | RotherhamvAldershotLeague Two · England | 1–0 | League Two · England |
| 2010-12-11 | BarnsleyvSheffield UnitedChampionship · England | 1–0 | Championship · England |
| 2010-12-11 | HuddersfieldvBrightonLeague One · England | 2–1 | League One · England |
| 2010-12-11 | ArlesvLilleLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-12-11 | StranraervBerwickLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2010-12-11 | CrotonevCittadellaSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-12-11 | East FifevStenhousemuirLeague One · Scotland | 6–0 | League One · Scotland |
| 2010-12-11 | AlcorconvElcheLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2010-12-11 | St MirrenvSt JohnstonePremiership · Scotland | 1–2 | Premiership · Scotland |
| 2010-12-11 | ShrewsburyvCheltenhamLeague Two · England | 1–1 | League Two · England |
| 2010-12-11 | SienavAscoliSerie B · Italy | 3–0 | Serie B · Italy |
| 2010-12-11 | PiacenzavLivornoSerie B · Italy | 0–1 | Serie B · Italy |
| 2010-12-11 | ReadingvCoventryChampionship · England | 0–0 | Championship · England |
| 2010-12-11 | BetisvCordobaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2010-12-11 | NorwichvPortsmouthChampionship · England | 0–2 | Championship · England |
| 2010-12-11 | EmpolivPortogruaroSerie B · Italy | 2–3 | Serie B · Italy |
| 2010-12-11 | StokevBlackpoolPremier League · England | 0–1 | Premier League · England |
| 2010-12-11 | KarabuksporvAntalyasporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2010-12-11 | Crystal PalacevHullChampionship · England | 0–0 | Championship · England |
| 2010-12-11 | LeicestervDoncasterChampionship · England | 5–1 | Championship · England |
| 2010-12-11 | ValladolidvNumanciaLa Liga 2 · Spain | 4–5 | La Liga 2 · Spain |
| 2010-12-11 | PaderbornvDuisburg2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2010-12-11 | Olympiakos VolouvArisSuper League · Greece | 1–1 | Super League · Greece |
| 2010-12-11 | HoffenheimvNurnbergBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2010-12-11 | PrestonvIpswichChampionship · England | 1–0 | Championship · England |
| 2010-12-10 | PonferradinavCartagenaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2010-12-10 | Greuther FurthvOberhausen2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |