| 2000-12-16 | EspanolvReal MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2000-12-16 | Aston VillavMan CityPremier League · England | 2–2 | Premier League · England |
| 2000-12-16 | HalifaxvHartlepoolLeague Two · England | 0–1 | League Two · England |
| 2000-12-16 | OberhausenvStuttgarter K2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2000-12-16 | Hansa RostockvDortmundBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2000-12-16 | CelticvAberdeenPremiership · Scotland | 6–0 | Premiership · Scotland |
| 2000-12-16 | MouscronvLouvieroisePro League · Belgium | 0–0 | Pro League · Belgium |
| 2000-12-16 | HibernianvSt JohnstonePremiership · Scotland | 2–0 | Premiership · Scotland |
| 2000-12-16 | BuryvOldhamLeague One · England | 1–1 | League One · England |
| 2000-12-16 | MacclesfieldvCarlisleLeague Two · England | 1–0 | League Two · England |
| 2000-12-16 | LensvBordeauxLigue 1 · France | 2–2 | Ligue 1 · France |
| 2000-12-16 | BrechinvElginLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2000-12-16 | Raith RvsvAlloaChampionship · Scotland | 2–1 | Championship · Scotland |
| 2000-12-16 | NewcastlevBradfordPremier League · England | 2–1 | Premier League · England |
| 2000-12-16 | Leyton OrientvDarlingtonLeague Two · England | 1–0 | League Two · England |
| 2000-12-16 | MotherwellvHeartsPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2000-12-16 | StirlingvClydebankLeague One · Scotland | 0–0 | League One · Scotland |
| 2000-12-16 | BarnetvScunthorpeLeague Two · England | 4–2 | League Two · England |
| 2000-12-16 | HamiltonvDumbartonLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2000-12-16 | LokerenvStandardPro League · Belgium | 2–1 | Pro League · Belgium |
| 2000-12-16 | QPRvNott'm ForestChampionship · England | 1–0 | Championship · England |
| 2000-12-16 | WrexhamvBrentfordLeague One · England | 2–1 | League One · England |
| 2000-12-16 | ArbroathvPartickLeague One · Scotland | 1–1 | League One · Scotland |
| 2000-12-16 | PlymouthvYorkLeague Two · England | 1–0 | League Two · England |
| 2000-12-16 | LeedsvSunderlandPremier League · England | 2–0 | Premier League · England |
| 2000-12-16 | SociedadvVillarrealLa Liga · Spain | 0–2 | La Liga · Spain |
| 2000-12-16 | MansfieldvBrightonLeague Two · England | 2–0 | League Two · England |
| 2000-12-16 | GaziantepsporvErzurumsporSüper Lig · Turkey | 6–1 | Süper Lig · Turkey |
| 2000-12-16 | StockportvBarnsleyChampionship · England | 2–0 | Championship · England |
| 2000-12-16 | JaenvLevanteLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2000-12-16 | OxfordvNorthamptonLeague One · England | 3–1 | League One · England |
| 2000-12-16 | GillinghamvPrestonChampionship · England | 4–0 | Championship · England |
| 2000-12-16 | MillwallvWalsallLeague One · England | 2–0 | League One · England |
| 2000-12-16 | LeiriavPortoPrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2000-12-16 | SedanvStrasbourgLigue 1 · France | 1–0 | Ligue 1 · France |
| 2000-12-16 | SwindonvRotherhamLeague One · England | 2–1 | League One · England |
| 2000-12-16 | LiersevMechelenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2000-12-16 | AlavesvLa CorunaLa Liga · Spain | 3–1 | La Liga · Spain |
| 2000-12-16 | LeicestervCharltonPremier League · England | 3–1 | Premier League · England |
| 2000-12-15 | UnterhachingvEin FrankfurtBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2000-12-15 | CambridgevPeterboroLeague One · England | 0–0 | League One · England |
| 2000-12-15 | UlmvDuisburg2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2000-12-15 | OsnabruckvBielefeld2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2000-12-15 | CharleroivWesterloPro League · Belgium | 2–2 | Pro League · Belgium |
| 2000-12-15 | PiacenzavChievoSerie B · Italy | 1–0 | Serie B · Italy |
| 2000-12-15 | FenerbahcevSamsunsporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2000-12-15 | CampomaiorensevGuimaraesPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2000-12-14 | St PaulivNurnberg2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2000-12-14 | Greuther FurthvHannover2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2000-12-13 | OberhausenvReutlingen2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |