| 2021-10-02 | PeterborovBristol CityChampionship · England | 2–3 | Championship · England |
| 2021-10-02 | KortrijkvCharleroiPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-10-02 | GrimsbyvDover AthleticNational League · England | 6–0 | National League · England |
| 2021-10-02 | SolihullvSouthendNational League · England | 2–0 | National League · England |
| 2021-10-02 | Sepsi Sf. GheorghevFC Rapid BucurestiSuperliga · Romania | 2–2 | Superliga · Romania |
| 2021-10-02 | ExetervWalsallLeague Two · England | 2–2 | League Two · England |
| 2021-10-02 | Holstein KielvHansa Rostock2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2021-10-02 | AlessandriavCosenzaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-10-02 | Dag and RedvAltrinchamNational League · England | 2–3 | National League · England |
| 2021-10-02 | BradfordvRochdaleLeague Two · England | 2–0 | League Two · England |
| 2021-10-02 | HullvMiddlesbroughChampionship · England | 2–0 | Championship · England |
| 2021-10-02 | Dynamo MoscowvKrylya SovetovPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-10-02 | PortovPacos FerreiraPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-10-02 | WycombevMorecambeLeague One · England | 4–3 | League One · England |
| 2021-10-02 | Rubin KazanvPari NNPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-10-02 | RB LeipzigvBochumBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2021-10-02 | CadizvValenciaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2021-10-02 | Vissel KobevUrawa RedsJ1 League · Japan | 5–1 | J1 League · Japan |
| 2021-10-02 | For SittardvNijmegenEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-10-02 | QPRvPrestonChampionship · England | 3–2 | Championship · England |
| 2021-10-02 | AroucavSp LisbonPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-10-02 | Oud-Heverlee LeuvenvBeerschot VAPro League · Belgium | 0–0 | Pro League · Belgium |
| 2021-10-02 | PisavRegginaSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-10-02 | ColchestervSalfordLeague Two · England | 0–2 | League Two · England |
| 2021-10-02 | RiedvA. KlagenfurtBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-10-02 | ZaragozavOviedoLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-10-02 | LincolnvPlymouthLeague One · England | 2–2 | League One · England |
| 2021-10-02 | RegensburgvKarlsruhe2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-10-02 | LongfordvBohemiansPremier Division · Ireland | 1–4 | Premier Division · Ireland |
| 2021-10-02 | Notts CountyvWokingNational League · England | 1–4 | National League · England |
| 2021-10-02 | LeedsvWatfordPremier League · England | 1–0 | Premier League · England |
| 2021-10-02 | DoncastervMilton Keynes DonsLeague One · England | 2–1 | League One · England |
| 2021-10-02 | AuxerrevNimesLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-10-02 | Newport CountyvScunthorpeLeague Two · England | 3–0 | League Two · England |
| 2021-10-02 | VizelavSanta ClaraPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-10-02 | VarbergvDegerforsAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-10-02 | Austin FCvReal Salt LakeMLS · United States | 2–1 | MLS · United States |
| 2021-10-02 | StevenagevHartlepoolLeague Two · England | 2–0 | League Two · England |
| 2021-10-02 | StenhousemuirvForfarLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2021-10-02 | EastleighvBoreham WoodNational League · England | 1–1 | National League · England |
| 2021-10-02 | AlcorconvSociedad BLa Liga 2 · Spain | 1–4 | La Liga 2 · Spain |
| 2021-10-02 | LuganovLausanneSuper League · Switzerland | 2–0 | Super League · Switzerland |
| 2021-10-02 | HamiltonvInverness CChampionship · Scotland | 2–1 | Championship · Scotland |
| 2021-10-02 | MaidenheadvKings LynnNational League · England | 2–3 | National League · England |
| 2021-10-02 | BurnleyvNorwichPremier League · England | 0–0 | Premier League · England |
| 2021-10-02 | SassuolovInterSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-10-02 | Ath MadridvBarcelonaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-10-02 | Paris FCvNancyLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-10-02 | Bristol RvsvSwindonLeague Two · England | 1–3 | League Two · England |
| 2021-10-02 | WaalwijkvGo Ahead EaglesEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |