| 2010-08-14 | Port ValevChesterfieldLeague Two · England | 1–1 | League Two · England |
| 2010-08-14 | NorthamptonvAccringtonLeague Two · England | 0–0 | League Two · England |
| 2010-08-14 | WolvesvStokePremier League · England | 2–1 | Premier League · England |
| 2010-08-14 | TottenhamvMan CityPremier League · England | 0–0 | Premier League · England |
| 2010-08-14 | StockportvWycombeLeague Two · England | 0–0 | League Two · England |
| 2010-08-14 | ScunthorpevNorwichChampionship · England | 0–1 | Championship · England |
| 2010-08-14 | AnderlechtvGerminalPro League · Belgium | 4–0 | Pro League · Belgium |
| 2010-08-14 | GaziantepsporvKasimpasaSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2010-08-14 | SunderlandvBirminghamPremier League · England | 2–2 | Premier League · England |
| 2010-08-14 | HuddersfieldvTranmereLeague One · England | 0–0 | League One · England |
| 2010-08-14 | SouthportvAFC WimbledonNational League · England | 0–1 | National League · England |
| 2010-08-14 | GentvEupenPro League · Belgium | 2–1 | Pro League · Belgium |
| 2010-08-14 | BrightonvRochdaleLeague One · England | 2–2 | League One · England |
| 2010-08-14 | MorecambevRotherhamLeague Two · England | 0–0 | League Two · England |
| 2010-08-14 | AZ AlkmaarvGroningenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2010-08-14 | DunfermlinevMortonChampionship · Scotland | 2–0 | Championship · Scotland |
| 2010-08-14 | StirlingvCowdenbeathChampionship · Scotland | 1–3 | Championship · Scotland |
| 2010-08-14 | Crawley TownvGrimsbyNational League · England | 0–1 | National League · England |
| 2010-08-14 | PartickvDundeeChampionship · Scotland | 1–0 | Championship · Scotland |
| 2010-08-14 | BrechinvStenhousemuirLeague One · Scotland | 0–0 | League One · Scotland |
| 2010-08-14 | BarnetvBurtonLeague Two · England | 0–0 | League Two · England |
| 2010-08-14 | TamworthvEastbourne BoroughNational League · England | 4–2 | National League · England |
| 2010-08-14 | ArlesvLensLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-08-14 | HistonvBarrowNational League · England | 3–1 | National League · England |
| 2010-08-14 | DarlingtonvNewport CountyNational League · England | 1–0 | National League · England |
| 2010-08-14 | StandardvLokerenPro League · Belgium | 3–3 | Pro League · Belgium |
| 2010-08-14 | BrestvAuxerreLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-08-14 | Queen of SthvRaith RvsChampionship · Scotland | 1–3 | Championship · Scotland |
| 2010-08-14 | WrexhamvCambridgeNational League · England | 1–0 | National League · England |
| 2010-08-14 | MechelenvLiersePro League · Belgium | 1–0 | Pro League · Belgium |
| 2010-08-14 | MillwallvHullChampionship · England | 4–0 | Championship · England |
| 2010-08-14 | AjaxvVitesseEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2010-08-14 | HerefordvGillinghamLeague Two · England | 0–0 | League Two · England |
| 2010-08-14 | BrentfordvWalsallLeague One · England | 1–2 | League One · England |
| 2010-08-14 | BradfordvStevenageLeague Two · England | 1–0 | League Two · England |
| 2010-08-14 | WiganvBlackpoolPremier League · England | 0–4 | Premier League · England |
| 2010-08-14 | StranraervAlbion RvsLeague Two · Scotland | 3–2 | League Two · Scotland |
| 2010-08-14 | HeartsvSt JohnstonePremiership · Scotland | 1–1 | Premiership · Scotland |
| 2010-08-14 | DumbartonvLivingstonLeague One · Scotland | 1–2 | League One · Scotland |
| 2010-08-14 | St EtiennevSochauxLigue 1 · France | 3–2 | Ligue 1 · France |
| 2010-08-14 | NancyvRennesLigue 1 · France | 0–3 | Ligue 1 · France |
| 2010-08-14 | PlymouthvCarlisleLeague One · England | 1–1 | League One · England |
| 2010-08-14 | DerbyvCardiffChampionship · England | 1–2 | Championship · England |
| 2010-08-14 | Aston VillavWest HamPremier League · England | 3–0 | Premier League · England |
| 2010-08-14 | PeterheadvForfarLeague One · Scotland | 1–2 | League One · Scotland |
| 2010-08-14 | WesterlovWaregemPro League · Belgium | 1–1 | Pro League · Belgium |
| 2010-08-14 | KortrijkvSt TruidenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2010-08-14 | East StirlingvMontroseLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2010-08-14 | SivassporvGalatasaraySüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2010-08-14 | MansfieldvForest GreenNational League · England | 3–1 | National League · England |