| 2021-10-02 | StranraervAlbion RvsLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2021-10-02 | MontpelliervStrasbourgLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-10-02 | Radomiak RadomvTermalica B-B.Ekstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-10-02 | CardiffvReadingChampionship · England | 0–1 | Championship · England |
| 2021-10-02 | AdmiravAltachBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2021-10-02 | Godoy CruzvNewells Old BoysLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2021-10-02 | BlackpoolvBlackburnChampionship · England | 2–1 | Championship · England |
| 2021-10-02 | WolfsburgvM'gladbachBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2021-10-02 | Avispa FukuokavShimizu S-PulseJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-10-02 | AlloavCove RangersLeague One · Scotland | 1–3 | League One · Scotland |
| 2021-10-02 | StuttgartvHoffenheimBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-10-02 | Queen of SthvDunfermlineChampionship · Scotland | 1–0 | Championship · Scotland |
| 2021-10-02 | CremonesevTernanaSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-10-02 | KuPSvIlvesVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2021-10-02 | JuarezvMonterreyLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-10-02 | HuescavTenerifeLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-02 | Atl. TucumanvSan LorenzoLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-10-02 | ArisvApollonSuper League · Greece | 0–0 | Super League · Greece |
| 2021-10-02 | OldhamvHarrogateLeague Two · England | 1–2 | League Two · England |
| 2021-10-02 | Kashiwa ReysolvVegalta SendaiJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-10-02 | FrosinonevCittadellaSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-10-02 | Lech PoznanvSlask WroclawEkstraklasa · Poland | 4–0 | Ekstraklasa · Poland |
| 2021-10-02 | AccringtonvIpswichLeague One · England | 2–1 | League One · England |
| 2021-10-02 | TorquayvWealdstoneNational League · England | 5–0 | National League · England |
| 2021-10-02 | ChelseavSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2021-10-02 | VikingvSandefjordEliteserien · Norway | 2–1 | Eliteserien · Norway |
| 2021-10-02 | KilmarnockvRaith RvsChampionship · Scotland | 1–3 | Championship · Scotland |
| 2021-10-02 | St TruidenvOostendePro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-10-02 | HuracanvArsenal SarandiLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-10-02 | GrenoblevPau FCLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-10-02 | CoventryvFulhamChampionship · England | 4–1 | Championship · England |
| 2021-10-02 | BarnsleyvMillwallChampionship · England | 0–1 | Championship · England |
| 2021-10-02 | OsasunavVallecanoLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-10-02 | ZwollevHeerenveenEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-10-02 | DerbyvSwanseaChampionship · England | 0–0 | Championship · England |
| 2021-10-02 | GoztepvGiresunsporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-10-02 | PlatensevPatronatoLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2021-10-02 | Sheffield WedsvOxfordLeague One · England | 1–2 | League One · England |
| 2021-10-02 | HalmstadvOstersundsAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-10-02 | BoltonvShrewsburyLeague One · England | 2–1 | League One · England |
| 2021-10-02 | Dundee UnitedvRoss CountyPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-10-02 | TorinovJuventusSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-10-02 | Fortuna DusseldorfvPaderborn2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2021-10-02 | Arsenal TulavKhimkiPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-10-02 | CarlislevForest GreenLeague Two · England | 0–2 | League Two · England |
| 2021-10-02 | BesiktasvSivassporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-10-02 | MallorcavLevanteLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-10-02 | ElginvStirlingLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2021-10-02 | Sligo RoversvWaterfordPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-10-02 | HeraclesvWillem IIEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |