| 2021-10-03 | Yeni MalatyasporvHataysporSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2021-10-03 | Guadalajara ChivasvAtlasLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-10-02 | MortonvArbroathChampionship · Scotland | 2–2 | Championship · Scotland |
| 2021-10-02 | Kawasaki FrontalevFC TokyoJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-10-02 | NorthamptonvSuttonLeague Two · England | 0–2 | League Two · England |
| 2021-10-02 | PortsmouthvSunderlandLeague One · England | 4–0 | League One · England |
| 2021-10-02 | CheltenhamvRotherhamLeague One · England | 0–2 | League One · England |
| 2021-10-02 | HeartsvMotherwellPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-10-02 | Gamba OsakavHokkaido Consadole SapporoJ1 League · Japan | 1–5 | J1 League · Japan |
| 2021-10-02 | PueblavPachucaLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2021-10-02 | CSKA MoscowvKrasnodarPremier League · Russia | 0–0 | Premier League · Russia |
| 2021-10-02 | CrotonevAscoliSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-10-02 | KonyasporvAlanyasporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-10-02 | HonkavMariehamnVeikkausliiga · Finland | 1–1 | Veikkausliiga · Finland |
| 2021-10-02 | SpalvParmaSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-10-02 | Port ValevLeyton OrientLeague Two · England | 3–2 | League Two · England |
| 2021-10-02 | Man UnitedvEvertonPremier League · England | 1–1 | Premier League · England |
| 2021-10-02 | GuingampvRodezLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-10-02 | TranmerevCrawley TownLeague Two · England | 2–1 | League Two · England |
| 2021-10-02 | DortmundvAugsburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-10-02 | AmiensvToulouseLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-10-02 | HerthavFreiburgBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-10-02 | Kelty HeartsvAnnan AthleticLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2021-10-02 | Volos NFCvAsteras TripolisSuper League · Greece | 2–1 | Super League · Greece |
| 2021-10-02 | BrightonvArsenalPremier League · England | 0–0 | Premier League · England |
| 2021-10-02 | St JohnstonevDundeePremiership · Scotland | 3–1 | Premiership · Scotland |
| 2021-10-02 | Wolfsberger ACvAustria ViennaBundesliga · Austria | 1–0 | Bundesliga · Austria |
| 2021-10-02 | CuiabavAmerica MGSerie A · Brazil | 0–2 | Serie A · Brazil |
| 2021-10-02 | MansfieldvBarrowLeague Two · England | 0–1 | League Two · England |
| 2021-10-02 | Sarpsborg 08vLillestromEliteserien · Norway | 2–1 | Eliteserien · Norway |
| 2021-10-02 | BournemouthvSheffield UnitedChampionship · England | 2–1 | Championship · England |
| 2021-10-02 | FalkirkvEast FifeLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-10-02 | Airdrie UtdvClydeLeague One · Scotland | 2–1 | League One · Scotland |
| 2021-10-02 | NurnbergvHannover2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-10-02 | DunkerquevBastiaLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-10-02 | PartickvAyrChampionship · Scotland | 4–0 | Championship · Scotland |
| 2021-10-02 | LivingstonvSt MirrenPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-10-02 | BarnetvHalifaxNational League · England | 0–0 | National League · England |
| 2021-10-02 | LutonvHuddersfieldChampionship · England | 0–0 | Championship · England |
| 2021-10-02 | GrasshoppersvSt. GallenSuper League · Switzerland | 5–2 | Super League · Switzerland |
| 2021-10-02 | FortalezavAtletico GOSerie A · Brazil | 0–3 | Serie A · Brazil |
| 2021-10-02 | GillinghamvWiganLeague One · England | 0–2 | League One · England |
| 2021-10-02 | SalernitanavGenoaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-10-02 | Kashima AntlersvYokohama FCJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-10-02 | BragantinovCorinthiansSerie A · Brazil | 2–2 | Serie A · Brazil |
| 2021-10-02 | Cercle BruggevSt. GilloisePro League · Belgium | 0–3 | Pro League · Belgium |
| 2021-10-02 | Fleetwood TownvCharltonLeague One · England | 1–2 | League One · England |
| 2021-10-02 | CaenvValenciennesLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-10-02 | AmorebietavSp GijonLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-02 | WeymouthvStockportNational League · England | 1–2 | National League · England |