| 2021-10-03 | Akhmat GroznyvSpartak MoscowPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-10-03 | OddvMoldeEliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2021-10-03 | FenerbahcevKasimpasaSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-10-03 | LorientvClermontLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-10-03 | HartbergvSturm GrazBundesliga · Austria | 3–2 | Bundesliga · Austria |
| 2021-10-03 | Chapecoense-SCvSao PauloSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-10-03 | HJKvSJKVeikkausliiga · Finland | 2–3 | Veikkausliiga · Finland |
| 2021-10-03 | EupenvGenkPro League · Belgium | 3–2 | Pro League · Belgium |
| 2021-10-03 | GaziantepvAltaySüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2021-10-03 | VitessevFeyenoordEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-10-03 | TromsovHaugesundEliteserien · Norway | 2–0 | Eliteserien · Norway |
| 2021-10-03 | FC VoluntarivFarul ConstantaSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-10-03 | Inter TurkuvHIFKVeikkausliiga · Finland | 2–0 | Veikkausliiga · Finland |
| 2021-10-03 | AjaxvUtrechtEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-10-03 | MalagavFuenlabradaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-10-03 | Sporting Kansas CityvHouston DynamoMLS · United States | 4–2 | MLS · United States |
| 2021-10-03 | Pogon SzczecinvLecznaEkstraklasa · Poland | 4–1 | Ekstraklasa · Poland |
| 2021-10-03 | Schalke 04vIngolstadt2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-10-03 | Club AmericavUNAM PumasLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-10-03 | Bayern MunichvEin FrankfurtBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-10-03 | BielefeldvLeverkusenBundesliga · Germany | 0–4 | Bundesliga · Germany |
| 2021-10-03 | NantesvTroyesLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-10-03 | GranadavSevillaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-10-03 | SandhausenvDarmstadt2. Bundesliga · Germany | 1–6 | 2. Bundesliga · Germany |
| 2021-10-03 | RomavEmpoliSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-10-03 | TottenhamvAston VillaPremier League · England | 2–1 | Premier League · England |
| 2021-10-03 | ServettevYoung BoysSuper League · Switzerland | 0–6 | Super League · Switzerland |
| 2021-10-03 | Lechia GdanskvLegiaEkstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2021-10-03 | LiverpoolvMan CityPremier League · England | 2–2 | Premier League · England |
| 2021-10-03 | Lokomotiv MoscowvFK RostovPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-10-03 | AngersvMetzLigue 1 · France | 3–2 | Ligue 1 · France |
| 2021-10-03 | Orlando CityvDC UnitedMLS · United States | 2–1 | MLS · United States |
| 2021-10-03 | Malmo FFvMjallbyAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2021-10-03 | PordenonevVicenzaSerie B · Italy | 2–4 | Serie B · Italy |
| 2021-10-03 | HakavAC OuluVeikkausliiga · Finland | 0–0 | Veikkausliiga · Finland |
| 2021-10-03 | MainzvUnion BerlinBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-10-03 | Rosario CentralvArgentinos JrsLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-10-03 | BresciavComoSerie B · Italy | 2–4 | Serie B · Italy |
| 2021-10-03 | UfavUralPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-10-03 | Flamengo RJvAthletico-PRSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2021-10-03 | VeronavSpeziaSerie A · Italy | 4–0 | Serie A · Italy |
| 2021-10-03 | AalborgvSonderjyskeSuperliga · Denmark | 4–0 | Superliga · Denmark |
| 2021-10-03 | River PlatevBoca JuniorsLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-10-03 | LillevMarseilleLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-10-03 | KristiansundvRosenborgEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2021-10-03 | AntwerpvGentPro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-10-03 | BurgosvMirandesLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-10-03 | OlympiakosvPanathinaikosSuper League · Greece | 0–0 | Super League · Greece |
| 2021-10-03 | CF MontrealvAtlanta UtdMLS · United States | 2–1 | MLS · United States |
| 2021-10-03 | MidtjyllandvAarhusSuperliga · Denmark | 4–0 | Superliga · Denmark |