| 2010-08-21 | WaregemvCercle BruggePro League · Belgium | 4–0 | Pro League · Belgium |
| 2010-08-21 | MarseillevLorientLigue 1 · France | 2–0 | Ligue 1 · France |
| 2010-08-21 | HoffenheimvWerder BremenBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2010-08-21 | West HamvBoltonPremier League · England | 1–3 | Premier League · England |
| 2010-08-21 | Bristol CityvBarnsleyChampionship · England | 3–3 | Championship · England |
| 2010-08-21 | AjaxvRodaEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2010-08-21 | CardiffvDoncasterChampionship · England | 4–0 | Championship · England |
| 2010-08-21 | AFC WimbledonvTamworthNational League · England | 3–0 | National League · England |
| 2010-08-21 | MontrosevArbroathLeague Two · Scotland | 3–0 | League Two · Scotland |
| 2010-08-21 | AccringtonvMacclesfieldLeague Two · England | 3–0 | League Two · England |
| 2010-08-21 | HeerenveenvNAC BredaEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2010-08-21 | St JohnstonevAberdeenPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2010-08-21 | CharltonvOldhamLeague One · England | 1–1 | League One · England |
| 2010-08-21 | ArsenalvBlackpoolPremier League · England | 6–0 | Premier League · England |
| 2010-08-21 | CambridgevSouthportNational League · England | 0–0 | National League · England |
| 2010-08-21 | ShrewsburyvAldershotLeague Two · England | 1–1 | League Two · England |
| 2010-08-21 | Kettering TownvDarlingtonNational League · England | 0–0 | National League · England |
| 2010-08-21 | Notts CountyvDag and RedLeague One · England | 1–0 | League One · England |
| 2010-08-21 | LiersevKortrijkPro League · Belgium | 1–2 | Pro League · Belgium |
| 2010-08-21 | AltrinchamvCrawley TownNational League · England | 0–1 | National League · England |
| 2010-08-21 | LyonvBrestLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-08-21 | BirminghamvBlackburnPremier League · England | 2–1 | Premier League · England |
| 2010-08-21 | ChesterfieldvHerefordLeague Two · England | 4–0 | League Two · England |
| 2010-08-21 | KidderminstervMansfieldNational League · England | 1–3 | National League · England |
| 2010-08-21 | West BromvSunderlandPremier League · England | 1–0 | Premier League · England |
| 2010-08-21 | QPRvScunthorpeChampionship · England | 2–0 | Championship · England |
| 2010-08-21 | LeedsvMillwallChampionship · England | 3–1 | Championship · England |
| 2010-08-21 | GillinghamvLincolnLeague Two · England | 0–1 | League Two · England |
| 2010-08-21 | TranmerevBournemouthLeague One · England | 0–3 | League One · England |
| 2010-08-21 | GerminalvWesterloPro League · Belgium | 0–0 | Pro League · Belgium |
| 2010-08-21 | YeovilvHartlepoolLeague One · England | 0–2 | League One · England |
| 2010-08-21 | FC KolnvKaiserslauternBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2010-08-21 | GroningenvGraafschapEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2010-08-21 | LokerenvAnderlechtPro League · Belgium | 0–3 | Pro League · Belgium |
| 2010-08-21 | ExetervBristol RvsLeague One · England | 2–2 | League One · England |
| 2010-08-21 | BarrowvRushden & DNational League · England | 2–0 | National League · England |
| 2010-08-21 | PaderbornvErzgebirge Aue2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2010-08-21 | BurnleyvLeicesterChampionship · England | 3–0 | Championship · England |
| 2010-08-21 | HamburgvSchalke 04Bundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-08-21 | Forest GreenvGatesheadNational League · England | 1–1 | National League · England |
| 2010-08-21 | RotherhamvCheltenhamLeague Two · England | 6–4 | League Two · England |
| 2010-08-21 | VitessevTwenteEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2010-08-21 | Albion RvsvQueens ParkLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2010-08-21 | Crystal PalacevIpswichChampionship · England | 1–2 | Championship · England |
| 2010-08-21 | RochdalevColchesterLeague One · England | 1–2 | League One · England |
| 2010-08-21 | BuryvNorthamptonLeague Two · England | 1–1 | League Two · England |
| 2010-08-21 | NacionalvBenficaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2010-08-21 | ForfarvBrechinLeague One · Scotland | 1–1 | League One · Scotland |
| 2010-08-21 | HannovervEin FrankfurtBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-08-21 | StokevTottenhamPremier League · England | 1–2 | Premier League · England |