| 2021-10-03 | NorrkopingvHammarbyAllsvenskan · Sweden | 3–1 | Allsvenskan · Sweden |
| 2021-10-03 | BaselvLuzernSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-10-03 | KalmarvSiriusAllsvenskan · Sweden | 3–1 | Allsvenskan · Sweden |
| 2021-10-03 | Sp BragavBoavistaPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-10-03 | BenficavPortimonensePrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-10-03 | OFI CretevPAOKSuper League · Greece | 1–3 | Super League · Greece |
| 2021-10-03 | EibarvIbizaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-10-03 | U Craiova 1948vUniv. CraiovaSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-10-03 | Queens ParkvMontroseLeague One · Scotland | 1–1 | League One · Scotland |
| 2021-10-03 | BolognavLazioSerie A · Italy | 3–0 | Serie A · Italy |
| 2021-10-03 | CFR ClujvGaz Metan MediasSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-10-03 | AtalantavMilanSerie A · Italy | 2–3 | Serie A · Italy |
| 2021-10-03 | EspanolvReal MadridLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-10-03 | West HamvBrentfordPremier League · England | 1–2 | Premier League · England |
| 2021-10-03 | PSV EindhovenvSparta RotterdamEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-10-03 | Gimnasia L.P.vSarmiento JuninLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-10-03 | AIKvDjurgardenAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-10-03 | VillarrealvBetisLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-10-03 | ZurichvSionSuper League · Switzerland | 6–2 | Super League · Switzerland |
| 2021-10-03 | ZenitvSochiPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-10-03 | St PaulivDresden2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-10-03 | GetafevSociedadLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-10-03 | LeganesvLugoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-03 | RakowvWarta PoznanEkstraklasa · Poland | 3–0 | Ekstraklasa · Poland |
| 2021-10-03 | MjondalenvBrannEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-10-03 | EstorilvGil VicentePrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-10-03 | Crystal PalacevLeicesterPremier League · England | 2–2 | Premier League · England |
| 2021-10-03 | FiorentinavNapoliSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-10-03 | FC CincinnativNew York Red BullsMLS · United States | 0–1 | MLS · United States |
| 2021-10-03 |  MonacovBordeauxLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-10-03 | SilkeborgvNordsjaellandSuperliga · Denmark | 4–1 | Superliga · Denmark |
| 2021-10-03 | SampdoriavUdineseSerie A · Italy | 3–3 | Serie A · Italy |
| 2021-10-03 | PanetolikosvAEKSuper League · Greece | 1–3 | Super League · Greece |
| 2021-10-03 | ValerengavStromsgodsetEliteserien · Norway | 3–0 | Eliteserien · Norway |
| 2021-10-03 | PalmeirasvJuventudeSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-10-03 | CambuurvAZ AlkmaarEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-10-03 | AnderlechtvClub BruggePro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-10-03 | Velez SarsfieldvIndependienteLiga Profesional · Argentina | 3–3 | Liga Profesional · Argentina |
| 2021-10-03 | SK RapidvTirolBundesliga · Austria | 5–2 | Bundesliga · Austria |
| 2021-10-03 | StabaekvBodo/GlimtEliteserien · Norway | 0–3 | Eliteserien · Norway |
| 2021-10-03 | RizesporvGalatasaraySüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2021-10-03 | Atletico-MGvInternacionalSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-10-03 | OrebrovHackenAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-10-03 | AtromitosvGianninaSuper League · Greece | 1–1 | Super League · Greece |
| 2021-10-03 | SeraingvWaregemPro League · Belgium | 5–1 | Pro League · Belgium |
| 2021-10-03 | BelenensesvTondelaPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-10-03 | St EtiennevLyonLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-10-03 | SalzburgvLASKBundesliga · Austria | 3–1 | Bundesliga · Austria |
| 2021-10-03 | Philadelphia UnionvColumbus CrewMLS · United States | 3–0 | MLS · United States |
| 2021-10-03 | IonikosvLamiaSuper League · Greece | 1–2 | Super League · Greece |