| 2010-08-22 | ModenavPiacenzaSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-08-22 | MainzvStuttgartBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2010-08-22 | GalatasarayvBursasporSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2010-08-22 | FulhamvMan UnitedPremier League · England | 2–2 | Premier League · England |
| 2010-08-22 | CowdenbeathvQueen of SthChampionship · Scotland | 1–3 | Championship · Scotland |
| 2010-08-22 | PortovBeira MarPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2010-08-22 | MontpelliervCaenLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-08-22 | Club BruggevMechelenPro League · Belgium | 1–2 | Pro League · Belgium |
| 2010-08-22 | PortogruarovCittadellaSerie B · Italy | 2–0 | Serie B · Italy |
| 2010-08-22 | KilmarnockvMotherwellPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2010-08-22 | MiddlesbroughvSheffield UnitedChampionship · England | 1–0 | Championship · England |
| 2010-08-22 | CelticvSt MirrenPremiership · Scotland | 4–0 | Premiership · Scotland |
| 2010-08-22 | OsnabruckvDuisburg2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2010-08-21 | HamiltonvHeartsPremiership · Scotland | 0–4 | Premiership · Scotland |
| 2010-08-21 | StenhousemuirvAlloaLeague One · Scotland | 0–1 | League One · Scotland |
| 2010-08-21 | BurtonvMorecambeLeague Two · England | 3–2 | League Two · England |
| 2010-08-21 | HullvWatfordChampionship · England | 0–0 | Championship · England |
| 2010-08-21 | ElginvEast StirlingLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2010-08-21 | Raith RvsvDunfermlineChampionship · Scotland | 2–0 | Championship · Scotland |
| 2010-08-21 | Sheffield WedsvBrightonLeague One · England | 1–0 | League One · England |
| 2010-08-21 | BesiktasvBuyuksehyrSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2010-08-21 | FreiburgvSt PauliBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2010-08-21 | M'gladbachvNurnbergBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2010-08-21 | GrimsbyvHayes & YeadingNational League · England | 1–2 | National League · England |
| 2010-08-21 | Lensv MonacoLigue 1 · France | 2–2 | Ligue 1 · France |
| 2010-08-21 | Newport CountyvHistonNational League · England | 2–2 | National League · England |
| 2010-08-21 | AyrvDumbartonLeague One · Scotland | 1–0 | League One · Scotland |
| 2010-08-21 | PrestonvPortsmouthChampionship · England | 1–0 | Championship · England |
| 2010-08-21 | TorquayvBradfordLeague Two · England | 2–0 | League Two · England |
| 2010-08-21 | SetubalvSp BragaPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2010-08-21 | FalkirkvStirlingChampionship · Scotland | 3–0 | Championship · Scotland |
| 2010-08-21 | Eastbourne BoroughvWrexhamNational League · England | 4–3 | National League · England |
| 2010-08-21 | SouthendvPort ValeLeague Two · England | 1–3 | League Two · England |
| 2010-08-21 | ToulousevArlesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2010-08-21 | RennesvSt EtienneLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-08-21 | ReadingvNott'm ForestChampionship · England | 1–1 | Championship · England |
| 2010-08-21 | AntalyasporvSivassporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2010-08-21 | East FifevPeterheadLeague One · Scotland | 2–1 | League One · Scotland |
| 2010-08-21 | NorwichvSwanseaChampionship · England | 2–0 | Championship · England |
| 2010-08-21 | PeterborovHuddersfieldLeague One · England | 4–2 | League One · England |
| 2010-08-21 | CoventryvDerbyChampionship · England | 2–1 | Championship · England |
| 2010-08-21 | Annan AthleticvStranraerLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2010-08-21 | EvertonvWolvesPremier League · England | 1–1 | Premier League · England |
| 2010-08-21 | WalsallvPlymouthLeague One · England | 2–1 | League One · England |
| 2010-08-21 | Bath CityvYorkNational League · England | 2–2 | National League · England |
| 2010-08-21 | AuxerrevValenciennesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-08-21 | WiganvChelseaPremier League · England | 0–6 | Premier League · England |
| 2010-08-21 | CarlislevMilton Keynes DonsLeague One · England | 4–1 | League One · England |
| 2010-08-21 | StevenagevStockportLeague Two · England | 3–1 | League Two · England |
| 2010-08-21 | DundeevRoss CountyChampionship · Scotland | 0–0 | Championship · Scotland |