| 2021-10-10 |  Central African Republicv NigeriaFIFA World Cup qualification | 0–2 | FIFA World Cup qualification |
| 2021-10-10 |  Spainv FranceUEFA Nations League | 1–2 | UEFA Nations League |
| 2021-10-10 | FuenlabradavLeganesLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-10-10 | AlcorconvBurgosLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-10-10 |  Beninv TanzaniaFIFA World Cup qualification | 0–1 | FIFA World Cup qualification |
| 2021-10-10 |  Madagascarv DR CongoFIFA World Cup qualification | 1–0 | FIFA World Cup qualification |
| 2021-10-10 |  Jamaicav CanadaFIFA World Cup qualification | 0–0 | FIFA World Cup qualification |
| 2021-10-10 |  Cape Verdev LiberiaFIFA World Cup qualification | 1–0 | FIFA World Cup qualification |
| 2021-10-10 | Sociedad BvPonferradinaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-10 | TenerifevAmorebietaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-10-10 |  Colombiav BrazilFIFA World Cup qualification | 0–0 | FIFA World Cup qualification |
| 2021-10-10 | FC CincinnativPhiladelphia UnionMLS · United States | 1–2 | MLS · United States |
| 2021-10-10 | Boca JuniorsvLanusLiga Profesional · Argentina | 4–2 | Liga Profesional · Argentina |
| 2021-10-10 |  Panamav United StatesFIFA World Cup qualification | 1–0 | FIFA World Cup qualification |
| 2021-10-10 |  Nepalv IndiaSAFF Cup | 0–1 | SAFF Cup |
| 2021-10-10 |  Venezuelav EcuadorFIFA World Cup qualification | 2–1 | FIFA World Cup qualification |
| 2021-10-10 |  Kenyav MaliFIFA World Cup qualification | 0–1 | FIFA World Cup qualification |
| 2021-10-10 | InternacionalvChapecoense-SCSerie A · Brazil | 5–2 | Serie A · Brazil |
| 2021-10-10 | Seattle SoundersvVancouver WhitecapsMLS · United States | 4–1 | MLS · United States |
| 2021-10-10 | JuventudevAmerica MGSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-10-10 | SantosvGremioSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-10-10 |  Argentinav UruguayFIFA World Cup qualification | 3–0 | FIFA World Cup qualification |
| 2021-10-10 |  Costa Ricav El SalvadorFIFA World Cup qualification | 2–1 | FIFA World Cup qualification |
| 2021-10-10 |  Mauritaniav TunisiaFIFA World Cup qualification | 0–0 | FIFA World Cup qualification |
| 2021-10-10 |  Chilev ParaguayFIFA World Cup qualification | 2–0 | FIFA World Cup qualification |
| 2021-10-09 | AlmeriavLas PalmasLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-09 | Sheffield WedsvBoltonLeague One · England | 1–0 | League One · England |
| 2021-10-09 | MansfieldvOldhamLeague Two · England | 0–0 | League Two · England |
| 2021-10-09 | Dover AthleticvBarnetNational League · England | 1–2 | National League · England |
| 2021-10-09 | StevenagevExeterLeague Two · England | 2–2 | League Two · England |
| 2021-10-09 | Athletico-PRvBahiaSerie A · Brazil | 0–2 | Serie A · Brazil |
| 2021-10-09 | LugovGironaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-10-09 |  Switzerlandv Northern IrelandFIFA World Cup qualification | 2–0 | FIFA World Cup qualification |
| 2021-10-09 | WokingvGrimsbyNational League · England | 0–1 | National League · England |
| 2021-10-09 | Boreham WoodvDag and RedNational League · England | 2–0 | National League · England |
| 2021-10-09 | Newells Old BoysvVelez SarsfieldLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2021-10-09 | PatronatovRacing ClubLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2021-10-09 | BromleyvTorquayNational League · England | 2–0 | National League · England |
| 2021-10-09 | Bristol RvsvCarlisleLeague Two · England | 3–0 | League Two · England |
| 2021-10-09 | RochdalevCrawley TownLeague Two · England | 0–1 | League Two · England |
| 2021-10-09 |  Hungaryv AlbaniaFIFA World Cup qualification | 0–1 | FIFA World Cup qualification |
| 2021-10-09 | MirandesvEibarLa Liga 2 · Spain | 3–3 | La Liga 2 · Spain |
| 2021-10-09 |  Moldovav DenmarkFIFA World Cup qualification | 0–4 | FIFA World Cup qualification |
| 2021-10-09 |  Andorrav EnglandFIFA World Cup qualification | 0–5 | FIFA World Cup qualification |
| 2021-10-09 |  Swedenv KosovoFIFA World Cup qualification | 3–0 | FIFA World Cup qualification |
| 2021-10-09 |  Senegalv NamibiaFIFA World Cup qualification | 4–1 | FIFA World Cup qualification |
| 2021-10-09 |  Faroe Islandsv AustriaFIFA World Cup qualification | 0–2 | FIFA World Cup qualification |
| 2021-10-09 | Forest GreenvSwindonLeague Two · England | 0–2 | League Two · England |
| 2021-10-09 | BanfieldvRiver PlateLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-10-09 |  Ghanav ZimbabweFIFA World Cup qualification | 3–1 | FIFA World Cup qualification |