| 2000-08-26 | AjacciovMontpellierLigue 2 · France | 0–2 | Ligue 2 · France |
| 2000-08-26 | West HamvMan UnitedPremier League · England | 2–2 | Premier League · England |
| 2000-08-26 | RochdalevScunthorpeLeague Two · England | 3–2 | League Two · England |
| 2000-08-26 | MillwallvWycombeLeague One · England | 1–2 | League One · England |
| 2000-08-26 | MechelenvMouscronPro League · Belgium | 1–5 | Pro League · Belgium |
| 2000-08-26 | BeauvaisvWasquehalLigue 2 · France | 0–0 | Ligue 2 · France |
| 2000-08-26 | SouthamptonvLiverpoolPremier League · England | 3–3 | Premier League · England |
| 2000-08-26 | NewcastlevTottenhamPremier League · England | 2–0 | Premier League · England |
| 2000-08-26 | WrexhamvWiganLeague One · England | 1–3 | League One · England |
| 2000-08-26 | LutonvBournemouthLeague One · England | 1–0 | League One · England |
| 2000-08-26 | GenclerbirligivFenerbahceSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2000-08-26 | CowdenbeathvElginLeague Two · Scotland | 3–1 | League Two · Scotland |
| 2000-08-26 | Willem IIvWaalwijkEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2000-08-26 | WolvesvBurnleyChampionship · England | 1–0 | Championship · England |
| 2000-08-26 | NAC BredavGroningenEredivisie · Netherlands | 5–1 | Eredivisie · Netherlands |
| 2000-08-26 | ChesterfieldvShrewsburyLeague Two · England | 3–0 | League Two · England |
| 2000-08-26 | ArsenalvCharltonPremier League · England | 5–3 | Premier League · England |
| 2000-08-26 | AZ AlkmaarvRoosendaalEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2000-08-26 | RotherhamvBuryLeague One · England | 1–2 | League One · England |
| 2000-08-26 | MontrosevEast FifeLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2000-08-26 | St JohnstonevKilmarnockPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2000-08-26 | PartickvBerwickLeague One · Scotland | 1–1 | League One · Scotland |
| 2000-08-26 | ClydebankvQueen of SthLeague One · Scotland | 1–2 | League One · Scotland |
| 2000-08-26 | IpswichvSunderlandPremier League · England | 1–0 | Premier League · England |
| 2000-08-26 | Le MansvCannesLigue 2 · France | 2–0 | Ligue 2 · France |
| 2000-08-26 | ExetervHartlepoolLeague Two · England | 1–1 | League Two · England |
| 2000-08-26 | Nott'm ForestvBirminghamChampionship · England | 1–2 | Championship · England |
| 2000-08-26 | CampomaiorensevSalgueirosPrimeira Liga · Portugal | 2–3 | Primeira Liga · Portugal |
| 2000-08-26 | StokevNotts CountyLeague One · England | 0–1 | League One · England |
| 2000-08-26 | PlymouthvMansfieldLeague Two · England | 2–0 | League Two · England |
| 2000-08-26 | East StirlingvHamiltonLeague Two · Scotland | 0–0 | League Two · Scotland |
| 2000-08-26 | FulhamvStockportChampionship · England | 4–1 | Championship · England |
| 2000-08-26 | KidderminstervHalifaxLeague Two · England | 2–1 | League Two · England |
| 2000-08-26 | AyrvFalkirkChampionship · Scotland | 5–2 | Championship · Scotland |
| 2000-08-26 | WimbledonvWatfordChampionship · England | 0–0 | Championship · England |
| 2000-08-26 | Sheffield UnitedvTranmereChampionship · England | 2–0 | Championship · England |
| 2000-08-26 | MarseillevGuingampLigue 1 · France | 3–1 | Ligue 1 · France |
| 2000-08-26 | NicevNancyLigue 2 · France | 2–1 | Ligue 2 · France |
| 2000-08-26 | ClydevMortonChampionship · Scotland | 0–3 | Championship · Scotland |
| 2000-08-26 | GraafschapvRoda JCEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2000-08-26 | SwanseavColchesterLeague One · England | 0–2 | League One · England |
| 2000-08-26 | St TruidenvGenkPro League · Belgium | 2–2 | Pro League · Belgium |
| 2000-08-26 | BordeauxvLensLigue 1 · France | 1–1 | Ligue 1 · France |
| 2000-08-26 | Raith RvsvInverness CChampionship · Scotland | 4–1 | Championship · Scotland |
| 2000-08-26 | DunfermlinevDundee UnitedPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2000-08-26 | BoltonvPrestonChampionship · England | 2–0 | Championship · England |
| 2000-08-26 | AnderlechtvBeverenPro League · Belgium | 4–0 | Pro League · Belgium |
| 2000-08-26 | CheltenhamvTorquayLeague Two · England | 2–0 | League Two · England |
| 2000-08-26 | OxfordvBrentfordLeague One · England | 0–1 | League One · England |
| 2000-08-26 | LincolnvBrightonLeague Two · England | 2–0 | League Two · England |