| 2010-12-12 | AnderlechtvLokerenPro League · Belgium | 0–0 | Pro League · Belgium |
| 2010-12-12 | XanthivKavalaSuper League · Greece | 1–1 | Super League · Greece |
| 2010-12-12 | VitessevAjaxEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2010-12-11 | West HamvMan CityPremier League · England | 1–3 | Premier League · England |
| 2010-12-11 | PartickvRoss CountyChampionship · Scotland | 1–1 | Championship · Scotland |
| 2010-12-11 | BarnetvAccringtonLeague Two · England | 2–0 | League Two · England |
| 2010-12-11 | Bayern MunichvSt PauliBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2010-12-11 | NAC BredavUtrechtEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2010-12-11 | PAOKvIraklisSuper League · Greece | 1–0 | Super League · Greece |
| 2010-12-11 | MorecambevPort ValeLeague Two · England | 1–0 | League Two · England |
| 2010-12-11 | Inverness CvRangersPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2010-12-11 | PescaravVicenzaSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-12-11 | StockportvCreweLeague Two · England | 3–3 | League Two · England |
| 2010-12-11 | ColchestervYeovilLeague One · England | 0–0 | League One · England |
| 2010-12-11 | BucasporvManisasporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2010-12-11 | GenoavNapoliSerie A · Italy | 0–1 | Serie A · Italy |
| 2010-12-11 | DunfermlinevQueen of SthChampionship · Scotland | 1–0 | Championship · Scotland |
| 2010-12-11 | LorientvLensLigue 1 · France | 3–0 | Ligue 1 · France |
| 2010-12-11 | PeterheadvBrechinLeague One · Scotland | 0–5 | League One · Scotland |
| 2010-12-11 | Notts CountyvMilton Keynes DonsLeague One · England | 2–0 | League One · England |
| 2010-12-11 | Frankfurt FSVvAugsburg2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2010-12-11 | ChesterfieldvTorquayLeague Two · England | 1–0 | League Two · England |
| 2010-12-11 | GenkvEupenPro League · Belgium | 5–1 | Pro League · Belgium |
| 2010-12-11 | Ath MadridvLa CorunaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2010-12-11 | BradfordvHerefordLeague Two · England | 1–0 | League Two · England |
| 2010-12-11 | Cercle BruggevWaregemPro League · Belgium | 1–3 | Pro League · Belgium |
| 2010-12-11 | GalatasarayvGenclerbirligiSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2010-12-11 | Villarreal BvHuescaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-12-11 | FC KolnvEin FrankfurtBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2010-12-11 | SouthamptonvBrentfordLeague One · England | 0–2 | League One · England |
| 2010-12-11 | PlymouthvExeterLeague One · England | 2–0 | League One · England |
| 2010-12-11 | StandardvSt TruidenPro League · Belgium | 1–0 | Pro League · Belgium |
| 2010-12-11 | Bristol CityvDerbyChampionship · England | 2–0 | Championship · England |
| 2010-12-11 | RodavDen HaagEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2010-12-11 | StevenagevNorthamptonLeague Two · England | 0–1 | League Two · England |
| 2010-12-11 | ModenavVareseSerie B · Italy | 0–2 | Serie B · Italy |
| 2010-12-11 | Sheffield WedsvBristol RvsLeague One · England | 6–2 | League One · England |
| 2010-12-11 | CarlislevDag and RedLeague One · England | 0–2 | League One · England |
| 2010-12-11 | FrosinonevNovaraSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-12-11 | MiddlesbroughvCardiffChampionship · England | 1–0 | Championship · England |
| 2010-12-11 | KaiserslauternvWolfsburgBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2010-12-11 | RegginavGrossetoSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-12-11 | MortonvDundeeChampionship · Scotland | 0–1 | Championship · Scotland |
| 2010-12-11 | GetafevVillarrealLa Liga · Spain | 1–0 | La Liga · Spain |
| 2010-12-11 | PalermovParmaSerie A · Italy | 3–1 | Serie A · Italy |
| 2010-12-11 | GraafschapvPSV EindhovenEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2010-12-11 | BrestvMontpellierLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-12-11 | NancyvSochauxLigue 1 · France | 1–0 | Ligue 1 · France |
| 2010-12-11 | BurnleyvLeedsChampionship · England | 2–3 | Championship · England |
| 2010-12-11 | NewcastlevLiverpoolPremier League · England | 3–1 | Premier League · England |