| 2000-12-16 | RizesporvIstanbulsporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2000-12-16 | BelenensesvAlvercaPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2000-12-16 | BochumvKaiserslauternBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2000-12-16 | Bristol RvsvStokeLeague One · England | 0–3 | League One · England |
| 2000-12-16 | WiganvWycombeLeague One · England | 2–1 | League One · England |
| 2000-12-16 | FC KolnvSchalke 04Bundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2000-12-16 | LutonvColchesterLeague One · England | 0–3 | League One · England |
| 2000-12-16 | KilmarnockvDundeePremiership · Scotland | 2–3 | Premiership · Scotland |
| 2000-12-16 | CrewevCrystal PalaceChampionship · England | 1–1 | Championship · England |
| 2000-12-16 | Munich 1860vHamburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2000-12-16 | FulhamvTranmereChampionship · England | 3–1 | Championship · England |
| 2000-12-16 | NAC BredavVitesseEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2000-12-16 | DerbyvCoventryPremier League · England | 1–0 | Premier League · England |
| 2000-12-16 |  South Africav LiberiaAfrican Cup of Nations qualification | 2–1 | African Cup of Nations qualification |
| 2000-12-16 | AntwerpvSt TruidenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2000-12-16 | MortonvLivingstonChampionship · Scotland | 1–2 | Championship · Scotland |
| 2000-12-16 | IraklisvXanthiSuper League · Greece | 1–0 | Super League · Greece |
| 2000-12-16 | VallecanovBarcelonaLa Liga · Spain | 2–2 | La Liga · Spain |
| 2000-12-16 | IpswichvSouthamptonPremier League · England | 3–1 | Premier League · England |
| 2000-12-16 | TenerifevMurciaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2000-12-16 | ZaragozavLas PalmasLa Liga · Spain | 3–1 | La Liga · Spain |
| 2000-12-16 | Willem IIvFor SittardEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2000-12-16 | St EtiennevAuxerreLigue 1 · France | 2–0 | Ligue 1 · France |
| 2000-12-16 | HullvTorquayLeague Two · England | 1–2 | League Two · England |
| 2000-12-16 | Inverness CvAirdrieChampionship · Scotland | 4–0 | Championship · Scotland |
| 2000-12-16 | CardiffvCheltenhamLeague Two · England | 3–1 | League Two · England |
| 2000-12-16 | BournemouthvSwanseaLeague One · England | 2–0 | League One · England |
| 2000-12-16 | AyrvRoss CountyChampionship · Scotland | 0–2 | Championship · Scotland |
| 2000-12-16 | MetzvLilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2000-12-16 | StuttgartvFreiburgBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2000-12-16 | SouthendvChesterfieldLeague Two · England | 3–2 | League Two · England |
| 2000-12-16 | PortsmouthvHuddersfieldChampionship · England | 1–1 | Championship · England |
| 2000-12-16 | PerugiavBariSerie A · Italy | 4–1 | Serie A · Italy |
| 2000-12-16 | Sheffield UnitedvSheffield WedsChampionship · England | 1–1 | Championship · England |
| 2000-12-16 | WolfsburgvLeverkusenBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2000-12-16 | WatfordvWest BromChampionship · England | 3–3 | Championship · England |
| 2000-12-16 | Notts CountyvReadingLeague One · England | 3–2 | League One · England |
| 2000-12-16 | GentvGerminalPro League · Belgium | 3–1 | Pro League · Belgium |
| 2000-12-16 | U.Las PalmasvSalamancaLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2000-12-16 | GuingampvMarseilleLigue 1 · France | 1–0 | Ligue 1 · France |
| 2000-12-16 | Queens ParkvBerwickLeague One · Scotland | 0–2 | League One · Scotland |
| 2000-12-16 | WimbledonvBoltonChampionship · England | 0–1 | Championship · England |
| 2000-12-16 |  MonacovRennesLigue 1 · France | 1–2 | Ligue 1 · France |
| 2000-12-16 | StranraervForfarLeague One · Scotland | 3–1 | League One · Scotland |
| 2000-12-16 | NapolivRegginaSerie A · Italy | 6–2 | Serie A · Italy |
| 2000-12-16 | BeverenvHarelbekePro League · Belgium | 2–1 | Pro League · Belgium |
| 2000-12-16 | BlackpoolvExeterLeague Two · England | 3–0 | League Two · England |
| 2000-12-16 | MainzvReutlingen2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2000-12-16 | AnderlechtvAalstPro League · Belgium | 3–0 | Pro League · Belgium |
| 2000-12-16 | DunfermlinevSt MirrenPremiership · Scotland | 2–0 | Premiership · Scotland |