| 2021-10-16 | Greuther FurthvBochumBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2021-10-16 | LillestromvKristiansundEliteserien · Norway | 0–0 | Eliteserien · Norway |
| 2021-10-16 | BoltonvWiganLeague One · England | 0–4 | League One · England |
| 2021-10-16 | St JohnstonevLivingstonPremiership · Scotland | 0–3 | Premiership · Scotland |
| 2021-10-16 | Sepsi Sf. GheorghevFC VoluntariSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-10-16 | LincolnvCharltonLeague One · England | 2–1 | League One · England |
| 2021-10-16 | MillwallvLutonChampionship · England | 0–2 | Championship · England |
| 2021-10-16 | HIFKvSJKVeikkausliiga · Finland | 2–2 | Veikkausliiga · Finland |
| 2021-10-16 | PanathinaikosvIonikosSuper League · Greece | 4–1 | Super League · Greece |
| 2021-10-16 | MilanvVeronaSerie A · Italy | 3–2 | Serie A · Italy |
| 2021-10-16 | CarlislevTranmereLeague Two · England | 0–1 | League Two · England |
| 2021-10-16 | ScunthorpevForest GreenLeague Two · England | 0–2 | League Two · England |
| 2021-10-16 | CosenzavFrosinoneSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-10-16 | ExetervNewport CountyLeague Two · England | 2–2 | League Two · England |
| 2021-10-16 | FCSBvMioveniSuperliga · Romania | 3–0 | Superliga · Romania |
| 2021-10-16 | GillinghamvSunderlandLeague One · England | 1–2 | League One · England |
| 2021-10-16 | ComovAlessandriaSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-10-16 | Slask WroclawvRakowEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-10-16 | FeyenoordvWaalwijkEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2021-10-16 | ZurichvLuganoSuper League · Switzerland | 1–0 | Super League · Switzerland |
| 2021-10-16 | Crawley TownvSuttonLeague Two · England | 0–1 | League Two · England |
| 2021-10-16 | MonterreyvClub LeonLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-10-16 | Inverness CvMortonChampionship · Scotland | 2–0 | Championship · Scotland |
| 2021-10-16 | Port ValevBarrowLeague Two · England | 3–1 | League Two · England |
| 2021-10-16 | Austria ViennavAdmiraBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2021-10-16 | OldhamvStevenageLeague Two · England | 3–0 | League Two · England |
| 2021-10-16 | LecznavPiast GliwiceEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-10-16 | Aston VillavWolvesPremier League · England | 2–3 | Premier League · England |
| 2021-10-16 | BastiavGrenobleLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-10-16 | DortmundvMainzBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-10-16 | StirlingvStranraerLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2021-10-16 | Gornik Z.vWislaEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-10-16 | Ross CountyvSt MirrenPremiership · Scotland | 2–3 | Premiership · Scotland |
| 2021-10-16 | Sarmiento JuninvUnion de Santa FeLiga Profesional · Argentina | 3–4 | Liga Profesional · Argentina |
| 2021-10-16 | StandardvOud-Heverlee LeuvenPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-10-16 | HamburgvFortuna Dusseldorf2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-10-16 | AyrvQueen of SthChampionship · Scotland | 2–1 | Championship · Scotland |
| 2021-10-16 | ForfarvAnnan AthleticLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2021-10-16 | IlvesvHJKVeikkausliiga · Finland | 2–3 | Veikkausliiga · Finland |
| 2021-10-16 | LeicestervMan UnitedPremier League · England | 4–2 | Premier League · England |
| 2021-10-16 | Lyonv MonacoLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-10-16 | RangersvHeartsPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-10-16 | NorwichvBrightonPremier League · England | 0–0 | Premier League · England |
| 2021-10-15 | EibarvAlmeriaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-10-15 | BurtonvMorecambeLeague One · England | 3–2 | League One · England |
| 2021-10-15 | West BromvBirminghamChampionship · England | 1–0 | Championship · England |
| 2021-10-15 | Racing ClubvPlatenseLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2021-10-15 | Shamrock RoversvSligo RoversPremier Division · Ireland | 2–0 | Premier Division · Ireland |
| 2021-10-15 | BohemiansvDundalkPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-10-15 | BuyuksehyrvBesiktasSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |