| 2008-09-14 | LaziovSampdoriaSerie A · Italy | 2–0 | Serie A · Italy |
| 2008-09-14 | SociedadvMurciaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2008-09-14 | AlmeriavValenciaLa Liga · Spain | 2–2 | La Liga · Spain |
| 2008-09-14 | CaenvSt EtienneLigue 1 · France | 2–0 | Ligue 1 · France |
| 2008-09-14 | GaziantepsporvAnkaragucuSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2008-09-14 | VillarrealvLa CorunaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2008-09-14 | SochauxvLilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2008-09-14 | BolognavAtalantaSerie A · Italy | 0–1 | Serie A · Italy |
| 2008-09-14 | CharleroivCercle BruggePro League · Belgium | 3–2 | Pro League · Belgium |
| 2008-09-14 | GenoavMilanSerie A · Italy | 2–0 | Serie A · Italy |
| 2008-09-14 | Hansa RostockvMainz2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2008-09-14 | BochumvBielefeldBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2008-09-14 | AjaxvRoda JCEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2008-09-14 | LevantevHerculesLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2008-09-14 | Greuther FurthvKoblenz2. Bundesliga · Germany | 4–3 | 2. Bundesliga · Germany |
| 2008-09-14 | PAOKvAEKSuper League · Greece | 1–1 | Super League · Greece |
| 2008-09-14 | Asteras TripolisvLarisaSuper League · Greece | 0–0 | Super League · Greece |
| 2008-09-14 | RegginavTorinoSerie A · Italy | 1–1 | Serie A · Italy |
| 2008-09-14 | QPRvSouthamptonChampionship · England | 4–1 | Championship · England |
| 2008-09-14 | AlbacetevGironaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2008-09-14 | StokevEvertonPremier League · England | 2–3 | Premier League · England |
| 2008-09-14 | ElchevTenerifeLa Liga 2 · Spain | 2–4 | La Liga 2 · Spain |
| 2008-09-13 | HamburgvLeverkusenBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2008-09-13 | OldhamvMilton Keynes DonsLeague One · England | 2–0 | League One · England |
| 2008-09-13 | TrevisovRiminiSerie B · Italy | 1–0 | Serie B · Italy |
| 2008-09-13 | DarlingtonvPort ValeLeague Two · England | 2–1 | League Two · England |
| 2008-09-13 | DerbyvSheffield UnitedChampionship · England | 2–1 | Championship · England |
| 2008-09-13 | GerminalvRoeselarePro League · Belgium | 3–0 | Pro League · Belgium |
| 2008-09-13 | BirminghamvDoncasterChampionship · England | 1–0 | Championship · England |
| 2008-09-13 | IraklisvOFISuper League · Greece | 1–1 | Super League · Greece |
| 2008-09-13 | ClydevPartickChampionship · Scotland | 1–1 | Championship · Scotland |
| 2008-09-13 | EmpolivAlbinoleffeSerie B · Italy | 0–0 | Serie B · Italy |
| 2008-09-13 | SassuolovGrossetoSerie B · Italy | 4–0 | Serie B · Italy |
| 2008-09-13 | AvellinovCittadellaSerie B · Italy | 0–0 | Serie B · Italy |
| 2008-09-13 | WokingvGraysNational League · England | 3–1 | National League · England |
| 2008-09-13 | CrewevColchesterLeague One · England | 2–0 | League One · England |
| 2008-09-13 | PalermovRomaSerie A · Italy | 3–1 | Serie A · Italy |
| 2008-09-13 | TwentevNijmegenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2008-09-13 | RotherhamvRochdaleLeague Two · England | 2–2 | League Two · England |
| 2008-09-13 | Bristol RvsvWalsallLeague One · England | 1–3 | League One · England |
| 2008-09-13 | BarivBresciaSerie B · Italy | 1–1 | Serie B · Italy |
| 2008-09-13 | CambridgevTorquayNational League · England | 0–1 | National League · England |
| 2008-09-13 | Den HaagvAZ AlkmaarEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2008-09-13 | BergenvAnderlechtPro League · Belgium | 1–2 | Pro League · Belgium |
| 2008-09-13 | StevenagevAltrinchamNational League · England | 3–0 | National League · England |
| 2008-09-13 | BournemouthvMacclesfieldLeague Two · England | 0–1 | League Two · England |
| 2008-09-13 | KonyasporvDenizlisporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2008-09-13 | RangersvKilmarnockPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2008-09-13 | ShrewsburyvGillinghamLeague Two · England | 7–0 | League Two · England |
| 2008-09-13 | CharltonvWolvesChampionship · England | 1–3 | Championship · England |