| 2021-10-17 | MjallbyvKalmarAllsvenskan · Sweden | 4–0 | Allsvenskan · Sweden |
| 2021-10-17 | AZ AlkmaarvUtrechtEredivisie · Netherlands | 5–1 | Eredivisie · Netherlands |
| 2021-10-17 | Austin FCvMinnesota UnitedMLS · United States | 0–1 | MLS · United States |
| 2021-10-17 | Beerschot VAvMechelenPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-10-17 | Wisla PlockvPogon SzczecinEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-10-17 | CagliarivSampdoriaSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-10-17 | SandefjordvOddEliteserien · Norway | 0–0 | Eliteserien · Norway |
| 2021-10-17 | DarmstadtvWerder Bremen2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-10-17 | BordeauxvNantesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-10-17 | LegiavLech PoznanEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-10-17 | New England RevolutionvChicago FireMLS · United States | 2–2 | MLS · United States |
| 2021-10-17 | FC CincinnativOrlando CityMLS · United States | 0–1 | MLS · United States |
| 2021-10-17 | BrondbyvVejleSuperliga · Denmark | 3–2 | Superliga · Denmark |
| 2021-10-17 | Houston DynamovSeattle SoundersMLS · United States | 2–1 | MLS · United States |
| 2021-10-17 | CittadellavSpalSerie B · Italy | 0–0 | Serie B · Italy |
| 2021-10-17 | TwentevWillem IIEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-10-17 | Toronto FCvAtlanta UtdMLS · United States | 0–2 | MLS · United States |
| 2021-10-17 | UdinesevBolognaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-10-17 | MetzvRennesLigue 1 · France | 0–3 | Ligue 1 · France |
| 2021-10-17 | Colon Santa FEvTalleres CordobaLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-10-17 | AldosivivIndependienteLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-10-17 | HuracanvBoca JuniorsLiga Profesional · Argentina | 0–3 | Liga Profesional · Argentina |
| 2021-10-17 | CremonesevBeneventoSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-10-17 | MontpelliervLensLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-10-17 | Krylya SovetovvPari NNPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-10-17 | StrasbourgvSt EtienneLigue 1 · France | 5–1 | Ligue 1 · France |
| 2021-10-17 | AugsburgvBielefeldBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-10-17 | UTA AradvU Craiova 1948Superliga · Romania | 1–0 | Superliga · Romania |
| 2021-10-17 | HaugesundvMjondalenEliteserien · Norway | 7–0 | Eliteserien · Norway |
| 2021-10-17 | NewcastlevTottenhamPremier League · England | 2–3 | Premier League · England |
| 2021-10-17 | SwanseavCardiffChampionship · England | 3–0 | Championship · England |
| 2021-10-17 | SionvBaselSuper League · Switzerland | 0–1 | Super League · Switzerland |
| 2021-10-17 | TirolvHartbergBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2021-10-17 | LausannevGrasshoppersSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2021-10-17 | Athletico-PRvFluminenseSerie A · Brazil | 0–1 | Serie A · Brazil |
| 2021-10-17 | LASKvWolfsberger ACBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-10-17 | Los Angeles GalaxyvPortland TimbersMLS · United States | 2–1 | MLS · United States |
| 2021-10-16 | Chapecoense-SCvFortalezaSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2021-10-16 | Yokohama F. MarinosvHokkaido Consadole SapporoJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-10-16 | AmorebietavCartagenaLa Liga 2 · Spain | 2–3 | La Liga 2 · Spain |
| 2021-10-16 | Vissel KobevAvispa FukuokaJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-10-16 | Fleetwood TownvCreweLeague One · England | 3–0 | League One · England |
| 2021-10-16 | ReadingvBarnsleyChampionship · England | 1–0 | Championship · England |
| 2021-10-16 | Albion RvsvElginLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2021-10-16 | SouthamptonvLeedsPremier League · England | 1–0 | Premier League · England |
| 2021-10-16 | Young BoysvLuzernSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-10-16 | PrestonvDerbyChampionship · England | 0–0 | Championship · England |
| 2021-10-16 | IngolstadtvHolstein Kiel2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-10-16 | MotherwellvCelticPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2021-10-16 | LanusvBanfieldLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |