| 2010-09-11 | WaregemvEupenPro League · Belgium | 0–0 | Pro League · Belgium |
| 2010-09-11 | ManisasporvAntalyasporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2010-09-11 | LutonvCambridgeNational League · England | 2–0 | National League · England |
| 2010-09-11 | DortmundvWolfsburgBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2010-09-11 | SouthportvMansfieldNational League · England | 1–2 | National League · England |
| 2010-09-11 | RennesvSochauxLigue 1 · France | 2–1 | Ligue 1 · France |
| 2010-09-11 | Fleetwood TownvKettering TownNational League · England | 4–1 | National League · England |
| 2010-09-11 | AFC WimbledonvBath CityNational League · England | 4–0 | National League · England |
| 2010-09-11 | Paris SGvArlesLigue 1 · France | 4–0 | Ligue 1 · France |
| 2010-09-11 | EmpolivTriestinaSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-09-11 | Dundee UnitedvAberdeenPremiership · Scotland | 3–1 | Premiership · Scotland |
| 2010-09-11 | Man CityvBlackburnPremier League · England | 1–1 | Premier League · England |
| 2010-09-11 | NorthamptonvSouthendLeague Two · England | 2–1 | League Two · England |
| 2010-09-11 | NovaravGrossetoSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-09-11 | TamworthvGrimsbyNational League · England | 2–1 | National League · England |
| 2010-09-11 | WrexhamvYorkNational League · England | 1–1 | National League · England |
| 2010-09-11 | ToulousevSt EtienneLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-09-11 | MontpelliervNancyLigue 1 · France | 1–2 | Ligue 1 · France |
| 2010-09-11 | Las PalmasvAlcorconLa Liga 2 · Spain | 4–1 | La Liga 2 · Spain |
| 2010-09-11 | AlbinoleffevVareseSerie B · Italy | 3–1 | Serie B · Italy |
| 2010-09-11 | BesiktasvAnkaragucuSüper Lig · Turkey | 4–0 | Süper Lig · Turkey |
| 2010-09-11 | CardiffvHullChampionship · England | 2–0 | Championship · England |
| 2010-09-11 | FreiburgvStuttgartBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-09-11 | LeedsvSwanseaChampionship · England | 2–1 | Championship · England |
| 2010-09-11 | West BromvTottenhamPremier League · England | 1–1 | Premier League · England |
| 2010-09-11 | HeerenveenvVitesseEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2010-09-11 | Leyton OrientvHuddersfieldLeague One · England | 1–2 | League One · England |
| 2010-09-11 | AZ AlkmaarvRodaEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2010-09-11 | ForfarvEast FifeLeague One · Scotland | 3–2 | League One · Scotland |
| 2010-09-11 | AuxerrevCaenLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-09-11 | GatesheadvAltrinchamNational League · England | 2–0 | National League · England |
| 2010-09-11 | St JohnstonevMotherwellPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2010-09-11 | ElchevBetisLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2010-09-11 | ArisvPanathinaikosSuper League · Greece | 0–1 | Super League · Greece |
| 2010-09-11 | WatfordvDoncasterChampionship · England | 2–2 | Championship · England |
| 2010-09-11 | DarlingtonvForest GreenNational League · England | 3–0 | National League · England |
| 2010-09-11 | BournemouthvDag and RedLeague One · England | 3–0 | League One · England |
| 2010-09-11 | Rushden & DvNewport CountyNational League · England | 0–1 | National League · England |
| 2010-09-11 | FrosinonevPortogruaroSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-09-11 | BarrowvEastbourne BoroughNational League · England | 4–0 | National League · England |
| 2010-09-11 | MortonvCowdenbeathChampionship · Scotland | 1–2 | Championship · Scotland |
| 2010-09-11 | CheltenhamvStevenageLeague Two · England | 1–0 | League Two · England |
| 2010-09-11 | EvertonvMan UnitedPremier League · England | 3–3 | Premier League · England |
| 2010-09-11 | M'gladbachvEin FrankfurtBundesliga · Germany | 0–4 | Bundesliga · Germany |
| 2010-09-11 | HannovervLeverkusenBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2010-09-11 | VVV VenlovTwenteEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2010-09-11 | AlbacetevGranadaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2010-09-11 | OlympiakosvKerkyraSuper League · Greece | 2–0 | Super League · Greece |
| 2010-09-11 | CagliarivRomaSerie A · Italy | 5–1 | Serie A · Italy |
| 2010-09-11 | ColchestervPlymouthLeague One · England | 1–1 | League One · England |