| 2021-10-17 | UralvCSKA MoscowPremier League · Russia | 0–1 | Premier League · Russia |
| 2021-10-17 | Atl. San LuisvClub AmericaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-10-17 | KasimpasavGoztepSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-10-17 | PachucavSantos LagunaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-10-17 | NapolivTorinoSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-10-17 | Guadalajara ChivasvTolucaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-10-17 | GremiovJuventudeSerie A · Brazil | 3–2 | Serie A · Brazil |
| 2021-10-17 | EmpolivAtalantaSerie A · Italy | 1–4 | Serie A · Italy |
| 2021-10-17 | Sparta RotterdamvGroningenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-10-17 | DC UnitedvNashville SCMLS · United States | 0–0 | MLS · United States |
| 2021-10-17 | TrabzonsporvFenerbahceSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2021-10-17 | RosenborgvValerengaEliteserien · Norway | 2–2 | Eliteserien · Norway |
| 2021-10-17 | Bodo/GlimtvSarpsborg 08Eliteserien · Norway | 2–1 | Eliteserien · Norway |
| 2021-10-17 | JuventusvRomaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-10-17 | NijmegenvVitesseEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-10-17 | EvertonvWest HamPremier League · England | 0–1 | Premier League · England |
| 2021-10-17 | CeltavSevillaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-10-17 | TroyesvNiceLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-10-17 | St TruidenvAnderlechtPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-10-17 | AEKvAtromitosSuper League · Greece | 3–0 | Super League · Greece |
| 2021-10-17 | Sturm GrazvRiedBundesliga · Austria | 1–0 | Bundesliga · Austria |
| 2021-10-17 | AltayvKaragumrukSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-10-17 | Oita TrinitavVegalta SendaiJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-10-17 | GoteborgvOrebroAllsvenskan · Sweden | 2–0 | Allsvenskan · Sweden |
| 2021-10-17 | Atletico GOvAtletico-MGSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-10-17 | BrannvStabaekEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-10-17 | GalatasarayvKonyasporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-10-17 | Sociedad BvOviedoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-17 | FC ArgesvFarul ConstantaSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-10-17 | New York Red BullsvNew York CityMLS · United States | 1–0 | MLS · United States |
| 2021-10-17 | GianninavOlympiakosSuper League · Greece | 1–2 | Super League · Greece |
| 2021-10-17 | StromsgodsetvVikingEliteserien · Norway | 0–1 | Eliteserien · Norway |
| 2021-10-17 | PanetolikosvOFI CreteSuper League · Greece | 1–2 | Super League · Greece |
| 2021-10-17 | CharleroivGenkPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-10-17 | BurgosvLugoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-17 | PAOKvVolos NFCSuper League · Greece | 4–4 | Super League · Greece |
| 2021-10-17 | America MGvBahiaSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-10-17 | MarseillevLorientLigue 1 · France | 4–1 | Ligue 1 · France |
| 2021-10-17 | Hansa RostockvSandhausen2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-10-17 | HammarbyvAIKAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-10-17 | St. GallenvServetteSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2021-10-17 | ParmavMonzaSerie B · Italy | 0–0 | Serie B · Italy |
| 2021-10-17 | VallecanovElcheLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-10-17 | OdensevRanders FCSuperliga · Denmark | 1–2 | Superliga · Denmark |
| 2021-10-17 | Cruz AzulvTigres UANLLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-10-17 | VillarrealvOsasunaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-10-17 | BarcelonavValenciaLa Liga · Spain | 3–1 | La Liga · Spain |
| 2021-10-17 | GentvEupenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-10-17 | KrasnodarvUfaPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-10-17 | IbizavMirandesLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |