| 2021-10-19 | CambridgevSheffield WedsLeague One · England | 1–1 | League One · England |
| 2021-10-19 | BradfordvHartlepoolLeague Two · England | 1–3 | League Two · England |
| 2021-10-19 | Leyton OrientvForest GreenLeague Two · England | 1–1 | League Two · England |
| 2021-10-19 | CharltonvAccringtonLeague One · England | 2–3 | League One · England |
| 2021-10-19 | HuescavMalagaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-10-19 | Newport CountyvCarlisleLeague Two · England | 2–2 | League Two · England |
| 2021-10-19 | Sheffield UnitedvMillwallChampionship · England | 1–2 | Championship · England |
| 2021-10-19 | PlatensevRosario CentralLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-10-19 | QPRvBlackburnChampionship · England | 1–0 | Championship · England |
| 2021-10-19 | Bristol CityvNott'm ForestChampionship · England | 1–2 | Championship · England |
| 2021-10-19 | NorthamptonvStevenageLeague Two · England | 3–0 | League Two · England |
| 2021-10-19 | MansfieldvPort ValeLeague Two · England | 1–1 | League Two · England |
| 2021-10-19 | OxfordvShrewsburyLeague One · England | 2–0 | League One · England |
| 2021-10-19 | QueretarovMonterreyLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-10-18 | River PlatevSan LorenzoLiga Profesional · Argentina | 3–1 | Liga Profesional · Argentina |
| 2021-10-18 | Flamengo RJvCuiabaSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-10-18 | AlanyasporvKayserisporSüper Lig · Turkey | 6–3 | Süper Lig · Turkey |
| 2021-10-18 | JagielloniavRadomiak RadomEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-10-18 | Sport RecifevSantosSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-10-18 | DjurgardenvElfsborgAllsvenskan · Sweden | 0–3 | Allsvenskan · Sweden |
| 2021-10-18 | Stal MielecvZaglebieEkstraklasa · Poland | 4–2 | Ekstraklasa · Poland |
| 2021-10-18 | AarhusvAalborgSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2021-10-18 | ArsenalvCrystal PalacePremier League · England | 2–2 | Premier League · England |
| 2021-10-18 | EspanolvCadizLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-10-18 | HataysporvGaziantepSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-10-18 | Vancouver WhitecapsvSporting Kansas CityMLS · United States | 2–1 | MLS · United States |
| 2021-10-18 | Univ. CraiovavAcademica ClinceniSuperliga · Romania | 5–0 | Superliga · Romania |
| 2021-10-18 | VeneziavFiorentinaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-10-18 | LamiavArisSuper League · Greece | 0–1 | Super League · Greece |
| 2021-10-18 | NimesvAjaccioLigue 2 · France | 0–2 | Ligue 2 · France |
| 2021-10-18 | AlavesvBetisLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-10-18 | FC BotosanivChindia TargovisteSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-10-18 | HackenvNorrkopingAllsvenskan · Sweden | 5–0 | Allsvenskan · Sweden |
| 2021-10-18 | Shamrock RoversvBohemiansPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-10-17 | KhimkivAkhmat GroznyPremier League · Russia | 2–0 | Premier League · Russia |
| 2021-10-17 | DresdenvNurnberg2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2021-10-17 | Real Salt LakevColorado RapidsMLS · United States | 3–1 | MLS · United States |
| 2021-10-17 | PalmeirasvInternacionalSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-10-17 | LeganesvValladolidLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-10-17 | UNAM PumasvJuarezLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-10-17 | NordsjaellandvMidtjyllandSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-10-17 | PonferradinavFuenlabradaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-10-17 | SonderjyskevFC CopenhagenSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-10-17 | FC Rapid BucurestivCFR ClujSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-10-17 | BrestvReimsLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-10-17 | Atl. TucumanvArgentinos JrsLiga Profesional · Argentina | 4–3 | Liga Profesional · Argentina |
| 2021-10-17 | CearavBragantinoSerie A · Brazil | 2–2 | Serie A · Brazil |
| 2021-10-17 | CracoviavWarta PoznanEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-10-17 | GenoavSassuoloSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-10-17 | LeverkusenvBayern MunichBundesliga · Germany | 1–5 | Bundesliga · Germany |