| 2010-09-12 | LaziovBolognaSerie A · Italy | 3–1 | Serie A · Italy |
| 2010-09-12 | AcademicavNavalPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2010-09-12 | VillarrealvEspanolLa Liga · Spain | 4–0 | La Liga · Spain |
| 2010-09-12 | NAC BredavFeyenoordEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-09-12 | GenoavChievoSerie A · Italy | 1–3 | Serie A · Italy |
| 2010-09-12 | PortimonensevRio AvePrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2010-09-12 | AEKvPanserraikosSuper League · Greece | 2–0 | Super League · Greece |
| 2010-09-12 | BresciavPalermoSerie A · Italy | 3–2 | Serie A · Italy |
| 2010-09-12 | MaritimovPacos FerreiraPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2010-09-12 | XerezvNumanciaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2010-09-12 | SevillavLa CorunaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2010-09-12 | Marseillev MonacoLigue 1 · France | 2–2 | Ligue 1 · France |
| 2010-09-12 | MainzvKaiserslauternBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-09-12 | NapolivBariSerie A · Italy | 2–2 | Serie A · Italy |
| 2010-09-12 | HerthavBielefeld2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2010-09-12 | Den HaagvGraafschapEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2010-09-12 | GroningenvUtrechtEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2010-09-12 | JuventusvSampdoriaSerie A · Italy | 3–3 | Serie A · Italy |
| 2010-09-12 | BirminghamvLiverpoolPremier League · England | 0–0 | Premier League · England |
| 2010-09-12 | Club BruggevGenkPro League · Belgium | 2–2 | Pro League · Belgium |
| 2010-09-12 | LarisavKavalaSuper League · Greece | 0–0 | Super League · Greece |
| 2010-09-12 | LeiriavNacionalPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2010-09-11 | CrewevBuryLeague Two · England | 3–0 | League Two · England |
| 2010-09-11 | PonferradinavVillarreal BLa Liga 2 · Spain | 1–5 | La Liga 2 · Spain |
| 2010-09-11 | BarcelonavHerculesLa Liga · Spain | 0–2 | La Liga · Spain |
| 2010-09-11 | BurnleyvPrestonChampionship · England | 4–3 | Championship · England |
| 2010-09-11 | ValenciavSantanderLa Liga · Spain | 1–0 | La Liga · Spain |
| 2010-09-11 | PortsmouthvIpswichChampionship · England | 0–0 | Championship · England |
| 2010-09-11 | AjaxvWillem IIEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-09-11 | West HamvChelseaPremier League · England | 1–3 | Premier League · England |
| 2010-09-11 | DunfermlinevDundeeChampionship · Scotland | 3–1 | Championship · Scotland |
| 2010-09-11 | DumbartonvStenhousemuirLeague One · Scotland | 1–0 | League One · Scotland |
| 2010-09-11 | LyonvValenciennesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-09-11 | QPRvMiddlesbroughChampionship · England | 3–0 | Championship · England |
| 2010-09-11 | RotherhamvBurtonLeague Two · England | 3–3 | League Two · England |
| 2010-09-11 | LensvLilleLigue 1 · France | 1–4 | Ligue 1 · France |
| 2010-09-11 | CeltavCordobaLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2010-09-11 | HamburgvNurnbergBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2010-09-11 | Sp LisbonvOlhanensePrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2010-09-11 | CharltonvNotts CountyLeague One · England | 1–0 | League One · England |
| 2010-09-11 | BerwickvArbroathLeague Two · Scotland | 4–1 | League Two · Scotland |
| 2010-09-11 | SassuolovTorinoSerie B · Italy | 1–2 | Serie B · Italy |
| 2010-09-11 | ScunthorpevBristol CityChampionship · England | 0–2 | Championship · England |
| 2010-09-11 | CesenavMilanSerie A · Italy | 2–0 | Serie A · Italy |
| 2010-09-11 | TorquayvAccringtonLeague Two · England | 0–0 | League Two · England |
| 2010-09-11 | SwindonvSouthamptonLeague One · England | 1–0 | League One · England |
| 2010-09-11 | AlloavAyrLeague One · Scotland | 4–1 | League One · Scotland |
| 2010-09-11 | LincolnvBarnetLeague Two · England | 1–0 | League Two · England |
| 2010-09-11 | AtromitosvIraklisSuper League · Greece | 1–1 | Super League · Greece |
| 2010-09-11 | StandardvCercle BruggePro League · Belgium | 2–0 | Pro League · Belgium |