| 2008-09-21 | HoffenheimvDortmundBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2008-09-21 | VolendamvTwenteEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2008-09-21 | LeccevSienaSerie A · Italy | 1–1 | Serie A · Italy |
| 2008-09-21 | HullvEvertonPremier League · England | 2–2 | Premier League · England |
| 2008-09-21 | MilanvLazioSerie A · Italy | 4–1 | Serie A · Italy |
| 2008-09-21 | ErgotelisvLevadeiakosSuper League · Greece | 1–1 | Super League · Greece |
| 2008-09-21 | ThrasyvoulosvAsteras TripolisSuper League · Greece | 0–2 | Super League · Greece |
| 2008-09-21 | RangersvMotherwellPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2008-09-21 | Sp GijonvBarcelonaLa Liga · Spain | 1–6 | La Liga · Spain |
| 2008-09-21 | TenerifevHuescaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2008-09-21 | ZaragozavElcheLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2008-09-21 | AyrvBrechinLeague One · Scotland | 1–1 | League One · Scotland |
| 2008-09-21 | St EtiennevParis SGLigue 1 · France | 1–0 | Ligue 1 · France |
| 2008-09-21 | OlympiakosvPanserraikosSuper League · Greece | 4–1 | Super League · Greece |
| 2008-09-21 | La CorunavMallorcaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2008-09-20 | NicevLe MansLigue 1 · France | 2–2 | Ligue 1 · France |
| 2008-09-20 | Rushden & DvBurtonNational League · England | 2–1 | National League · England |
| 2008-09-20 | SunderlandvMiddlesbroughPremier League · England | 2–0 | Premier League · England |
| 2008-09-20 | SwanseavBurnleyChampionship · England | 1–1 | Championship · England |
| 2008-09-20 | WatfordvReadingChampionship · England | 2–2 | Championship · England |
| 2008-09-20 | M'gladbachvHerthaBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2008-09-20 | WycombevDag and RedLeague Two · England | 2–1 | League Two · England |
| 2008-09-20 | WeymouthvKidderminsterNational League · England | 1–2 | National League · England |
| 2008-09-20 | MorecambevGrimsbyLeague Two · England | 1–1 | League Two · England |
| 2008-09-20 | RochdalevChesterfieldLeague Two · England | 2–1 | League Two · England |
| 2008-09-20 | Queen of SthvSt JohnstoneChampionship · Scotland | 2–2 | Championship · Scotland |
| 2008-09-20 | GrossetovParmaSerie B · Italy | 1–0 | Serie B · Italy |
| 2008-09-20 | Annan AthleticvForfarLeague Two · Scotland | 1–3 | League Two · Scotland |
| 2008-09-20 | ToulousevSochauxLigue 1 · France | 2–1 | Ligue 1 · France |
| 2008-09-20 | St MirrenvFalkirkPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2008-09-20 | CottbusvBochumBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2008-09-20 | DendervWaregemPro League · Belgium | 2–0 | Pro League · Belgium |
| 2008-09-20 | AldershotvGillinghamLeague Two · England | 2–1 | League Two · England |
| 2008-09-20 | SouthamptonvBarnsleyChampionship · England | 0–0 | Championship · England |
| 2008-09-20 | West HamvNewcastlePremier League · England | 3–1 | Premier League · England |
| 2008-09-20 | NorwichvSheffield UnitedChampionship · England | 1–0 | Championship · England |
| 2008-09-20 | BoltonvArsenalPremier League · England | 1–3 | Premier League · England |
| 2008-09-20 | NantesvValenciennesLigue 1 · France | 2–0 | Ligue 1 · France |
| 2008-09-20 | Crystal PalacevPlymouthChampionship · England | 1–2 | Championship · England |
| 2008-09-20 | BarrowvKettering TownNational League · England | 2–4 | National League · England |
| 2008-09-20 | HeartsvInverness CPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2008-09-20 | FrosinonevTrevisoSerie B · Italy | 1–0 | Serie B · Italy |
| 2008-09-20 | DerbyvCardiffChampionship · England | 1–1 | Championship · England |
| 2008-09-20 | RoeselarevLokerenPro League · Belgium | 0–1 | Pro League · Belgium |
| 2008-09-20 | BielefeldvFC KolnBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2008-09-20 | WesterlovMouscronPro League · Belgium | 0–0 | Pro League · Belgium |
| 2008-09-20 | Ath MadridvRecreativoLa Liga · Spain | 4–0 | La Liga · Spain |
| 2008-09-20 | CoventryvQPRChampionship · England | 1–0 | Championship · England |
| 2008-09-20 | DundeevLivingstonChampionship · Scotland | 0–3 | Championship · Scotland |
| 2008-09-20 | AZ AlkmaarvPSV EindhovenEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |