| 2021-10-23 | Milton Keynes DonsvRotherhamLeague One · England | 0–3 | League One · England |
| 2021-10-23 | SochauxvQuevilly RouenLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-10-23 | MillwallvStokeChampionship · England | 2–1 | Championship · England |
| 2021-10-23 | HerthavM'gladbachBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-10-23 | Columbus CrewvNew York Red BullsMLS · United States | 1–2 | MLS · United States |
| 2021-10-23 | EastleighvAltrinchamNational League · England | 2–1 | National League · England |
| 2021-10-23 | Schalke 04vDresden2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-10-23 | ChelseavNorwichPremier League · England | 7–0 | Premier League · England |
| 2021-10-22 | Willem IIvFor SittardEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-10-22 | Erzgebirge AuevIngolstadt2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2021-10-22 | EibarvCartagenaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-10-22 | AlessandriavCrotoneSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-10-22 | SeraingvCharleroiPro League · Belgium | 1–3 | Pro League · Belgium |
| 2021-10-22 | VejlevNordsjaellandSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-10-22 | St EtiennevAngersLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-10-22 | SJKvIlvesVeikkausliiga · Finland | 4–2 | Veikkausliiga · Finland |
| 2021-10-22 | InternacionalvBragantinoSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-10-22 | Radomiak RadomvLecznaEkstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2021-10-22 | GuimaraesvMaritimoPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-10-22 | MainzvAugsburgBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2021-10-22 | LahtivAC OuluVeikkausliiga · Finland | 0–0 | Veikkausliiga · Finland |
| 2021-10-22 | Dynamo MoscowvKhimkiPremier League · Russia | 4–1 | Premier League · Russia |
| 2021-10-22 | Lech PoznanvWisla PlockEkstraklasa · Poland | 4–1 | Ekstraklasa · Poland |
| 2021-10-22 | OsasunavGranadaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-10-22 | TorinovGenoaSerie A · Italy | 3–2 | Serie A · Italy |
| 2021-10-22 | PaderbornvHamburg2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-10-22 | SampdoriavSpeziaSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-10-22 | U Craiova 1948vGaz Metan MediasSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-10-22 | Chindia TargovistevUniv. CraiovaSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-10-22 | Urawa RedsvKashiwa ReysolJ1 League · Japan | 5–1 | J1 League · Japan |
| 2021-10-22 | ArsenalvAston VillaPremier League · England | 3–1 | Premier League · England |
| 2021-10-22 | Talleres CordobavRiver PlateLiga Profesional · Argentina | 0–2 | Liga Profesional · Argentina |
| 2021-10-22 | Yeni MalatyasporvAltaySüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-10-21 | Houston DynamovLos Angeles GalaxyMLS · United States | 0–3 | MLS · United States |
| 2021-10-21 | Tigres UANLvPachucaLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2021-10-21 | Nashville SCvColumbus CrewMLS · United States | 1–1 | MLS · United States |
| 2021-10-21 | AlmeriavSociedad BLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-10-21 | MirandesvGironaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-21 | Orlando CityvCF MontrealMLS · United States | 1–1 | MLS · United States |
| 2021-10-21 | ZaragozavPonferradinaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-21 | IndependientevSarmiento JuninLiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-10-21 | FC CincinnativChicago FireMLS · United States | 3–4 | MLS · United States |
| 2021-10-21 | Atlanta UtdvNew York CityMLS · United States | 1–1 | MLS · United States |
| 2021-10-21 | TolucavNecaxaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-10-21 | FC DallasvLos Angeles FCMLS · United States | 2–3 | MLS · United States |
| 2021-10-21 | Minnesota UnitedvPhiladelphia UnionMLS · United States | 3–2 | MLS · United States |
| 2021-10-21 | San Jose EarthquakesvAustin FCMLS · United States | 4–0 | MLS · United States |
| 2021-10-21 | Portland TimbersvVancouver WhitecapsMLS · United States | 2–3 | MLS · United States |
| 2021-10-21 | Argentinos JrsvColon Santa FELiga Profesional · Argentina | 3–1 | Liga Profesional · Argentina |
| 2021-10-21 | OviedovBurgosLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |