| 2010-09-18 | HibernianvHamiltonPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2010-09-18 | AlcorconvGironaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2010-09-18 | GroningenvExcelsiorEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2010-09-18 | NumanciavCartagenaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2010-09-18 | Crystal PalacevBurnleyChampionship · England | 0–0 | Championship · England |
| 2010-09-18 | KidderminstervCambridgeNational League · England | 0–0 | National League · England |
| 2010-09-18 | EvertonvNewcastlePremier League · England | 0–1 | Premier League · England |
| 2010-09-18 | Airdrie UtdvPeterheadLeague One · Scotland | 2–2 | League One · Scotland |
| 2010-09-18 | MotherwellvAberdeenPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2010-09-18 | WesterlovLiersePro League · Belgium | 2–0 | Pro League · Belgium |
| 2010-09-18 | EspanolvAlmeriaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2010-09-18 | SouthendvMorecambeLeague Two · England | 2–3 | League Two · England |
| 2010-09-18 | BuryvHerefordLeague Two · England | 1–1 | League Two · England |
| 2010-09-18 | Eastbourne BoroughvAltrinchamNational League · England | 5–0 | National League · England |
| 2010-09-18 | OxfordvStockportLeague Two · England | 0–1 | League Two · England |
| 2010-09-18 | Dag and RedvBristol RvsLeague One · England | 0–3 | League One · England |
| 2010-09-18 | VitessevNAC BredaEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2010-09-18 | SociedadvReal MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2010-09-18 | StuttgartvM'gladbachBundesliga · Germany | 7–0 | Bundesliga · Germany |
| 2010-09-18 | St EtiennevMontpellierLigue 1 · France | 3–0 | Ligue 1 · France |
| 2010-09-18 | StokevWest HamPremier League · England | 1–1 | Premier League · England |
| 2010-09-18 | BerwickvStranraerLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2010-09-18 | HuddersfieldvYeovilLeague One · England | 4–2 | League One · England |
| 2010-09-18 | TranmerevCharltonLeague One · England | 1–1 | League One · England |
| 2010-09-18 | KarlsruhevPaderborn2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2010-09-18 | ArbroathvAlbion RvsLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2010-09-18 | Queen of SthvPartickChampionship · Scotland | 2–1 | Championship · Scotland |
| 2010-09-18 | SienavAtalantaSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-09-18 | LivornovPortogruaroSerie B · Italy | 0–0 | Serie B · Italy |
| 2010-09-18 | Bristol CityvCoventryChampionship · England | 1–2 | Championship · England |
| 2010-09-18 | ExetervPeterboroLeague One · England | 2–2 | League One · England |
| 2010-09-18 | BarrowvForest GreenNational League · England | 3–0 | National League · England |
| 2010-09-18 | OldhamvBournemouthLeague One · England | 2–1 | League One · England |
| 2010-09-18 | MillwallvWatfordChampionship · England | 1–6 | Championship · England |
| 2010-09-18 | Aston VillavBoltonPremier League · England | 1–1 | Premier League · England |
| 2010-09-18 | IpswichvCardiffChampionship · England | 2–0 | Championship · England |
| 2010-09-18 | St JohnstonevSt MirrenPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2010-09-18 | BarnetvRotherhamLeague Two · England | 1–4 | League Two · England |
| 2010-09-18 | Beira MarvMaritimoPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2010-09-17 | Greuther FurthvFrankfurt FSV2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2010-09-17 | DijonvEvian Thonon GaillardLigue 2 · France | 5–1 | Ligue 2 · France |
| 2010-09-17 | AjacciovVannesLigue 2 · France | 3–0 | Ligue 2 · France |
| 2010-09-17 | GraafschapvHeerenveenEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2010-09-17 | AccringtonvLincolnLeague Two · England | 3–0 | League Two · England |
| 2010-09-17 | LutonvAFC WimbledonNational League · England | 3–0 | National League · England |
| 2010-09-17 | ClermontvNimesLigue 2 · France | 2–0 | Ligue 2 · France |
| 2010-09-17 | VaresevPescaraSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-09-17 | GrenoblevTroyesLigue 2 · France | 0–2 | Ligue 2 · France |
| 2010-09-17 | AachenvCottbus2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2010-09-17 | Union BerlinvHertha2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |