| 2021-10-23 | BrightonvMan CityPremier League · England | 1–4 | Premier League · England |
| 2021-10-23 | WeymouthvWealdstoneNational League · England | 1–1 | National League · England |
| 2021-10-23 | Forest GreenvSalfordLeague Two · England | 3–1 | League Two · England |
| 2021-10-23 | ChesterfieldvBoreham WoodNational League · England | 2–1 | National League · England |
| 2021-10-23 | Bristol RvsvNewport CountyLeague Two · England | 1–3 | League Two · England |
| 2021-10-23 | Notts CountyvStockportNational League · England | 2–1 | National League · England |
| 2021-10-23 | Wolfsberger ACvA. KlagenfurtBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-10-23 | ShrewsburyvCambridgeLeague One · England | 4–1 | League One · England |
| 2021-10-23 | SouthamptonvBurnleyPremier League · England | 2–2 | Premier League · England |
| 2021-10-23 | KonyasporvKayserisporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-10-23 | FK RostovvArsenal TulaPremier League · Russia | 4–0 | Premier League · Russia |
| 2021-10-23 | MontrosevEast FifeLeague One · Scotland | 4–1 | League One · Scotland |
| 2021-10-23 | GoztepvTrabzonsporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-10-23 | AldershotvBromleyNational League · England | 2–3 | National League · England |
| 2021-10-23 | LutonvHullChampionship · England | 1–0 | Championship · England |
| 2021-10-23 | ZwollevHeraclesEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-10-23 | StabaekvMoldeEliteserien · Norway | 0–3 | Eliteserien · Norway |
| 2021-10-23 | SalernitanavEmpoliSerie A · Italy | 2–4 | Serie A · Italy |
| 2021-10-23 | FortalezavAthletico-PRSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2021-10-23 | MonterreyvNecaxaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-10-23 | FC TokyovKashima AntlersJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-10-23 | BolognavMilanSerie A · Italy | 2–4 | Serie A · Italy |
| 2021-10-23 | Dundee UnitedvMotherwellPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2021-10-23 | WislavSlask WroclawEkstraklasa · Poland | 0–5 | Ekstraklasa · Poland |
| 2021-10-23 | Mazatlan FCvQueretaroLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-10-23 | SwindonvBradfordLeague Two · England | 1–3 | League Two · England |
| 2021-10-23 | Asteras TripolisvPanathinaikosSuper League · Greece | 2–1 | Super League · Greece |
| 2021-10-23 | Santa ClaravFamalicaoPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-10-23 | MonzavCittadellaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-10-23 | Sp LisbonvMoreirensePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-10-23 | Austria ViennavRiedBundesliga · Austria | 4–1 | Bundesliga · Austria |
| 2021-10-23 | LongfordvShamrock RoversPremier Division · Ireland | 0–1 | Premier Division · Ireland |
| 2021-10-23 | HeartsvDundeePremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-10-23 | TorquayvKings LynnNational League · England | 2–0 | National League · England |
| 2021-10-23 | Vegalta SendaivSanfrecce HiroshimaJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-10-23 | IpswichvFleetwood TownLeague One · England | 2–1 | League One · England |
| 2021-10-23 | Din. BucurestivFC Rapid BucurestiSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-10-23 | HackenvHalmstadAllsvenskan · Sweden | 2–3 | Allsvenskan · Sweden |
| 2021-10-23 | JuventudevCearaSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-10-23 | AmiensvValenciennesLigue 2 · France | 3–0 | Ligue 2 · France |
| 2021-10-23 | Seattle SoundersvSporting Kansas CityMLS · United States | 1–2 | MLS · United States |
| 2021-10-23 | RB LeipzigvGreuther FurthBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2021-10-23 | BielefeldvDortmundBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2021-10-23 | Ath BilbaovVillarrealLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-10-23 | TondelavPortoPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2021-10-23 | GrimsbyvYeovilNational League · England | 2–0 | National League · England |
| 2021-10-23 | KilmarnockvHamiltonChampionship · Scotland | 2–1 | Championship · Scotland |
| 2021-10-23 | Sheffield WedsvLincolnLeague One · England | 1–1 | League One · England |
| 2021-10-23 | ScunthorpevCrawley TownLeague Two · England | 2–1 | League Two · England |
| 2021-10-23 | Le HavrevPau FCLigue 2 · France | 1–0 | Ligue 2 · France |