| 2010-09-18 | BlackburnvFulhamPremier League · England | 1–1 | Premier League · England |
| 2010-09-18 | Werder BremenvMainzBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2010-09-18 | WalsallvSwindonLeague One · England | 1–2 | League One · England |
| 2010-09-18 | DundeevRaith RvsChampionship · Scotland | 0–0 | Championship · Scotland |
| 2010-09-18 | East FifevAyrLeague One · Scotland | 2–3 | League One · Scotland |
| 2010-09-18 | Notts CountyvLeyton OrientLeague One · England | 3–2 | League One · England |
| 2010-09-18 | MacclesfieldvPort ValeLeague Two · England | 0–3 | League Two · England |
| 2010-09-18 | Newport CountyvMansfieldNational League · England | 1–0 | National League · England |
| 2010-09-18 | BrentfordvHartlepoolLeague One · England | 0–0 | League One · England |
| 2010-09-18 | Sp GijonvAth BilbaoLa Liga · Spain | 2–2 | La Liga · Spain |
| 2010-09-18 | GrossetovPiacenzaSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-09-18 | SwanseavScunthorpeChampionship · England | 2–0 | Championship · England |
| 2010-09-18 | NancyvBrestLigue 1 · France | 0–2 | Ligue 1 · France |
| 2010-09-18 | HistonvTamworthNational League · England | 1–2 | National League · England |
| 2010-09-18 | PlymouthvSheffield WedsLeague One · England | 3–2 | League One · England |
| 2010-09-18 | LorientvCaenLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-09-18 | PrestonvNorwichChampionship · England | 0–1 | Championship · England |
| 2010-09-18 | Milton Keynes DonsvRochdaleLeague One · England | 1–1 | League One · England |
| 2010-09-18 | Queens ParkvEast StirlingLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2010-09-18 | BrechinvLivingstonLeague One · Scotland | 1–3 | League One · Scotland |
| 2010-09-18 | CittadellavFrosinoneSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-09-18 | CarlislevBrightonLeague One · England | 0–0 | League One · England |
| 2010-09-18 | ShrewsburyvNorthamptonLeague Two · England | 3–1 | League Two · England |
| 2010-09-18 | SouthportvRushden & DNational League · England | 2–2 | National League · England |
| 2010-09-18 | SochauxvNiceLigue 1 · France | 4–0 | Ligue 1 · France |
| 2010-09-18 | MallorcavOsasunaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2010-09-18 | ArlesvMarseilleLigue 1 · France | 0–3 | Ligue 1 · France |
| 2010-09-18 | BucasporvGalatasaraySüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2010-09-18 | Ross CountyvStirlingChampionship · Scotland | 3–1 | Championship · Scotland |
| 2010-09-18 | AlbinoleffevCrotoneSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-09-18 | ChesterfieldvCheltenhamLeague Two · England | 3–0 | League Two · England |
| 2010-09-18 | EupenvGerminalPro League · Belgium | 0–1 | Pro League · Belgium |
| 2010-09-18 | SivassporvEskisehirsporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2010-09-18 | DunfermlinevCowdenbeathChampionship · Scotland | 2–1 | Championship · Scotland |
| 2010-09-18 | TorinovNovaraSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-09-18 | MilanvCataniaSerie A · Italy | 1–1 | Serie A · Italy |
| 2010-09-18 | IraklisvLarisaSuper League · Greece | 1–0 | Super League · Greece |
| 2010-09-18 | ClydevAnnan AthleticLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2010-09-18 | SouthamptonvColchesterLeague One · England | 0–0 | League One · England |
| 2010-09-18 | SunderlandvArsenalPremier League · England | 1–1 | Premier League · England |
| 2010-09-18 | BurtonvCreweLeague Two · England | 1–1 | League Two · England |
| 2010-09-18 | Kettering TownvWrexhamNational League · England | 1–1 | National League · England |
| 2010-09-18 | ValenciennesvLensLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-09-18 | KavalavPanathinaikosSuper League · Greece | 2–2 | Super League · Greece |
| 2010-09-18 | Bayern MunichvFC KolnBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2010-09-18 | AntalyasporvKayserisporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2010-09-18 | LeicestervQPRChampionship · England | 0–2 | Championship · England |
| 2010-09-18 | AldershotvWycombeLeague Two · England | 0–0 | League Two · England |
| 2010-09-18 | StevenagevTorquayLeague Two · England | 0–0 | League Two · England |
| 2010-09-18 | AnkaragucuvKasimpasaSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |