| 2021-12-19 | OlympiakosvLamiaSuper League · Greece | 1–0 | Super League · Greece |
| 2021-12-19 | Ath BilbaovBetisLa Liga · Spain | 3–2 | La Liga · Spain |
| 2021-12-19 | TorinovVeronaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-12-19 | MilanvNapoliSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-12-19 | Guangzhou CityvBeijing GuoanSuper League · China | 5–0 | Super League · China |
| 2021-12-19 | AlessandriavParmaSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-12-19 | EupenvCharleroiPro League · Belgium | 0–4 | Pro League · Belgium |
| 2021-12-19 | TottenhamvLiverpoolPremier League · England | 2–2 | Premier League · England |
| 2021-12-18 | LivingstonvRoss CountyPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-12-18 |  Myanmarv PhilippinesAFF Championship | 2–3 | AFF Championship |
| 2021-12-18 | StranraervKelty HeartsLeague Two · Scotland | 0–4 | League Two · Scotland |
| 2021-12-18 | AscolivCremoneseSerie B · Italy | 1–4 | Serie B · Italy |
| 2021-12-18 | Cove RangersvAlloaLeague One · Scotland | 3–0 | League One · Scotland |
| 2021-12-18 | Bristol CityvHuddersfieldChampionship · England | 2–3 | Championship · England |
| 2021-12-18 | SevillavAth MadridLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-12-18 | ZwollevTwenteEredivisie · Netherlands | 1–3 | Eredivisie · Netherlands |
| 2021-12-18 | PortimonensevAroucaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2021-12-18 | BarcelonavElcheLa Liga · Spain | 3–2 | La Liga · Spain |
| 2021-12-18 | MorecambevFleetwood TownLeague One · England | 0–0 | League One · England |
| 2021-12-18 |  Tunisiav AlgeriaArab Cup | 0–2 | Arab Cup |
| 2021-12-18 | IbizavSp GijonLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-12-18 | PaderbornvHeidenheim2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-12-18 | ComovRegginaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-12-18 | Pogon SzczecinvWarta PoznanEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-12-18 | TondelavPacos FerreiraPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-12-18 | FrosinonevSpalSerie B · Italy | 4–0 | Serie B · Italy |
| 2021-12-18 | SociedadvVillarrealLa Liga · Spain | 1–3 | La Liga · Spain |
| 2021-12-18 | RB LeipzigvBielefeldBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2021-12-18 | CagliarivUdineseSerie A · Italy | 0–4 | Serie A · Italy |
| 2021-12-18 | GentvSt TruidenPro League · Belgium | 2–1 | Pro League · Belgium |
| 2021-12-18 | Ein FrankfurtvMainzBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-12-18 | SalfordvStevenageLeague Two · England | 1–0 | League Two · England |
| 2021-12-18 | OxfordvWiganLeague One · England | 2–3 | League One · England |
| 2021-12-18 | BlackburnvBirminghamChampionship · England | 4–0 | Championship · England |
| 2021-12-18 | TranmerevLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2021-12-18 | Gil VicentevSp LisbonPrimeira Liga · Portugal | 0–3 | Primeira Liga · Portugal |
| 2021-12-18 | SuttonvHarrogateLeague Two · England | 1–0 | League Two · England |
| 2021-12-18 | IpswichvSunderlandLeague One · England | 1–1 | League One · England |
| 2021-12-18 | HerthavDortmundBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2021-12-18 | HoffenheimvM'gladbachBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-12-18 | Piast GliwicevStal MielecEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-12-18 | Beerschot VAvOostendePro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-12-18 | MalagavLeganesLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-12-18 | IngolstadtvDresden2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-12-18 | MotherwellvSt JohnstonePremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-12-18 | St. GilloisevCercle BruggePro League · Belgium | 3–2 | Pro League · Belgium |
| 2021-12-18 | AtalantavRomaSerie A · Italy | 1–4 | Serie A · Italy |
| 2021-12-18 | PlymouthvCharltonLeague One · England | 1–0 | League One · England |
| 2021-12-18 | Queen of SthvAyrChampionship · Scotland | 3–0 | Championship · Scotland |
| 2021-12-18 | VallecanovAlavesLa Liga · Spain | 2–0 | La Liga · Spain |