| 2016-12-19 | QuilmesvTemperleyLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2016-12-18 |  MonacovLyonLigue 1 · France | 1–3 | Ligue 1 · France |
| 2016-12-18 | Targu MuresvPanduriiSuperliga · Romania | 3–0 | Superliga · Romania |
| 2016-12-18 | LeganesvEibarLa Liga · Spain | 1–1 | La Liga · Spain |
| 2016-12-18 | BarcelonavEspanolLa Liga · Spain | 4–1 | La Liga · Spain |
| 2016-12-18 | AnderlechtvEupenPro League · Belgium | 4–0 | Pro League · Belgium |
| 2016-12-18 | Den HaagvSparta RotterdamEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2016-12-18 | BielefeldvDresden2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2016-12-18 | NicevDijonLigue 1 · France | 2–1 | Ligue 1 · France |
| 2016-12-18 | GuimaraesvSetubalPrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2016-12-18 | Wurzburger KickersvStuttgart2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2016-12-18 | HannovervSandhausen2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2016-12-18 | ExcelsiorvNijmegenEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2016-12-18 | GaziantepsporvRizesporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2016-12-18 | UdinesevCrotoneSerie A · Italy | 2–0 | Serie A · Italy |
| 2016-12-18 | OlympiakosvPanetolikosSuper League · Greece | 3–1 | Super League · Greece |
| 2016-12-18 | La CorunavOsasunaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2016-12-18 | Boca JuniorsvColon Santa FELiga Profesional · Argentina | 4–1 | Liga Profesional · Argentina |
| 2016-12-18 | VallecanovZaragozaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2016-12-18 | Olimpo Bahia BlancavRiver PlateLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2016-12-18 | QPRvAston VillaChampionship · England | 0–1 | Championship · England |
| 2016-12-18 | LeverkusenvIngolstadtBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2016-12-18 | GenkvStandardPro League · Belgium | 2–2 | Pro League · Belgium |
| 2016-12-18 | BeneventovAscoliSerie B · Italy | 0–0 | Serie B · Italy |
| 2016-12-18 | BournemouthvSouthamptonPremier League · England | 1–3 | Premier League · England |
| 2016-12-18 | Slask WroclawvArka GdyniaEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2016-12-18 | LaziovFiorentinaSerie A · Italy | 3–1 | Serie A · Italy |
| 2016-12-18 | BelgranovRosario CentralLiga Profesional · Argentina | 0–2 | Liga Profesional · Argentina |
| 2016-12-18 | Newells Old BoysvSan Martin S.J.Liga Profesional · Argentina | 6–1 | Liga Profesional · Argentina |
| 2016-12-18 | PescaravBolognaSerie A · Italy | 0–3 | Serie A · Italy |
| 2016-12-18 | AlanyasporvAkhisar BelediyesporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2016-12-18 | ChievovSampdoriaSerie A · Italy | 2–1 | Serie A · Italy |
| 2016-12-18 | OsmanlisporvGalatasaraySüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2016-12-18 | Club BruggevKortrijkPro League · Belgium | 5–1 | Pro League · Belgium |
| 2016-12-18 | AdanasporvKayserisporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2016-12-18 | AltachvSK RapidBundesliga · Austria | 3–1 | Bundesliga · Austria |
| 2016-12-18 | NumanciavMallorcaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2016-12-18 | Sp LisbonvSp BragaPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2016-12-18 | MarseillevLilleLigue 1 · France | 2–0 | Ligue 1 · France |
| 2016-12-18 | Poli IasivDin. BucurestiSuperliga · Romania | 3–1 | Superliga · Romania |
| 2016-12-18 | IraklisvAsteras TripolisSuper League · Greece | 1–1 | Super League · Greece |
| 2016-12-18 | HeraclesvZwolleEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2016-12-18 | CaenvMetzLigue 1 · France | 3–0 | Ligue 1 · France |
| 2016-12-18 | AjaxvPSV EindhovenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2016-12-18 | TondelavBoavistaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2016-12-18 | CadizvSevilla BLa Liga 2 · Spain | 4–1 | La Liga 2 · Spain |
| 2016-12-18 | Man CityvArsenalPremier League · England | 2–1 | Premier League · England |
| 2016-12-18 | LegiavLecznaEkstraklasa · Poland | 5–0 | Ekstraklasa · Poland |
| 2016-12-18 | SassuolovInterSerie A · Italy | 0–1 | Serie A · Italy |
| 2016-12-18 | DarmstadtvBayern MunichBundesliga · Germany | 0–1 | Bundesliga · Germany |