| 2008-12-20 | MontrosevAlbion RvsLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2008-12-20 | YorkvEbbsfleetNational League · England | 3–1 | National League · England |
| 2008-12-20 | SalernitanavAscoliSerie B · Italy | 1–2 | Serie B · Italy |
| 2008-12-20 | EspanolvAth MadridLa Liga · Spain | 2–3 | La Liga · Spain |
| 2008-12-20 | GrenoblevLe MansLigue 1 · France | 2–1 | Ligue 1 · France |
| 2008-12-20 | Bristol CityvBurnleyChampionship · England | 1–2 | Championship · England |
| 2008-12-20 | BirminghamvReadingChampionship · England | 1–3 | Championship · England |
| 2008-12-20 | Sp LisbonvAcademicaPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2008-12-20 | PeterheadvAyrLeague One · Scotland | 3–0 | League One · Scotland |
| 2008-12-20 | BournemouthvBuryLeague Two · England | 2–0 | League Two · England |
| 2008-12-20 | HuddersfieldvHerefordLeague One · England | 2–0 | League One · England |
| 2008-12-20 | CheltenhamvWalsallLeague One · England | 0–0 | League One · England |
| 2008-12-20 | StockportvBristol RvsLeague One · England | 3–1 | League One · England |
| 2008-12-20 | GerminalvTubizePro League · Belgium | 2–0 | Pro League · Belgium |
| 2008-12-20 | NorthamptonvCarlisleLeague One · England | 1–0 | League One · England |
| 2008-12-20 | ColchestervScunthorpeLeague One · England | 0–0 | League One · England |
| 2008-12-20 | KilmarnockvSt MirrenPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2008-12-20 | Rushden & DvNorthwichNational League · England | 2–1 | National League · England |
| 2008-12-20 | Roda JCvGroningenEredivisie · Netherlands | 2–5 | Eredivisie · Netherlands |
| 2008-12-20 | ZaragozavAlicanteLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2008-12-20 | BergenvWaregemPro League · Belgium | 2–2 | Pro League · Belgium |
| 2008-12-20 | PiacenzavPisaSerie B · Italy | 1–0 | Serie B · Italy |
| 2008-12-20 | StranraervEast FifeLeague One · Scotland | 0–4 | League One · Scotland |
| 2008-12-20 | Las PalmasvAlbaceteLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2008-12-20 | AltrinchamvBurtonNational League · England | 1–3 | National League · England |
| 2008-12-20 | SienavInterSerie A · Italy | 1–2 | Serie A · Italy |
| 2008-12-20 | MouscronvClub BruggePro League · Belgium | 5–1 | Pro League · Belgium |
| 2008-12-20 | SpartavHeerenveenEredivisie · Netherlands | 4–1 | Eredivisie · Netherlands |
| 2008-12-20 | LaziovPalermoSerie A · Italy | 1–0 | Serie A · Italy |
| 2008-12-20 | AlloavBrechinLeague One · Scotland | 2–1 | League One · Scotland |
| 2008-12-20 | DerbyvWatfordChampionship · England | 1–0 | Championship · England |
| 2008-12-20 | ToulousevNiceLigue 1 · France | 2–2 | Ligue 1 · France |
| 2008-12-20 | ShrewsburyvWycombeLeague Two · England | 0–1 | League Two · England |
| 2008-12-20 | MillwallvCreweLeague One · England | 0–0 | League One · England |
| 2008-12-20 | DoncastervWolvesChampionship · England | 0–1 | Championship · England |
| 2008-12-20 | BradfordvChesterLeague Two · England | 0–0 | League Two · England |
| 2008-12-20 | AnconavTriestinaSerie B · Italy | 2–1 | Serie B · Italy |
| 2008-12-20 | DundeevPartickChampionship · Scotland | 0–0 | Championship · Scotland |
| 2008-12-20 | Sheffield UnitedvCrystal PalaceChampionship · England | 2–2 | Championship · England |
| 2008-12-20 | BarnsleyvPlymouthChampionship · England | 2–0 | Championship · England |
| 2008-12-20 | NorwichvCharltonChampionship · England | 1–0 | Championship · England |
| 2008-12-20 | St EtiennevAuxerreLigue 1 · France | 2–0 | Ligue 1 · France |
| 2008-12-20 | HacettepesporvKayserisporSüper Lig · Turkey | 0–3 | Süper Lig · Turkey |
| 2008-12-20 | MacclesfieldvDag and RedLeague Two · England | 0–4 | League Two · England |
| 2008-12-20 | LeicestervPeterboroLeague One · England | 4–0 | League One · England |
| 2008-12-20 | HamiltonvMotherwellPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2008-12-20 | GillinghamvBrentfordLeague Two · England | 1–1 | League Two · England |
| 2008-12-20 | LutonvMorecambeLeague Two · England | 1–1 | League Two · England |
| 2008-12-20 | ForfarvStenhousemuirLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2008-12-20 | TrevisovAvellinoSerie B · Italy | 2–1 | Serie B · Italy |