| 2000-12-17 | ArisvPanahaikiSuper League · Greece | 0–0 | Super League · Greece |
| 2000-12-17 | NantesvToulouseLigue 1 · France | 3–2 | Ligue 1 · France |
| 2000-12-17 | ValenciavMalagaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2000-12-17 | GraafschapvUtrechtEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2000-12-17 | VeronavMilanSerie A · Italy | 1–1 | Serie A · Italy |
| 2000-12-17 | OviedovSantanderLa Liga · Spain | 1–0 | La Liga · Spain |
| 2000-12-17 | AntalyasporvGenclerbirligiSüper Lig · Turkey | 4–2 | Süper Lig · Turkey |
| 2000-12-17 | ParmavVicenzaSerie A · Italy | 0–2 | Serie A · Italy |
| 2000-12-17 | GroningenvFeyenoordEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2000-12-17 | PanioniosvKalamataSuper League · Greece | 1–1 | Super League · Greece |
| 2000-12-17 | NijmegenvRoda JCEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2000-12-17 | MonzavRavennaSerie B · Italy | 0–1 | Serie B · Italy |
| 2000-12-17 | BurnleyvBlackburnChampionship · England | 0–2 | Championship · England |
| 2000-12-17 | NurnbergvHannover2. Bundesliga · Germany | 4–2 | 2. Bundesliga · Germany |
| 2000-12-17 | AZ AlkmaarvPSV EindhovenEredivisie · Netherlands | 0–5 | Eredivisie · Netherlands |
| 2000-12-17 | CosenzavTernanaSerie B · Italy | 0–0 | Serie B · Italy |
| 2000-12-17 | ChemnitzvGreuther Furth2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2000-12-17 | Man UnitedvLiverpoolPremier League · England | 0–1 | Premier League · England |
| 2000-12-17 | SalernitanavCrotoneSerie B · Italy | 0–1 | Serie B · Italy |
| 2000-12-17 | ValladolidvAth BilbaoLa Liga · Spain | 0–0 | La Liga · Spain |
| 2000-12-17 | Pacos FerreiravSp LisbonPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2000-12-17 | Ath MadridvLleidaLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2000-12-17 | OsasunavNumanciaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2000-12-17 | BolognavAtalantaSerie A · Italy | 0–1 | Serie A · Italy |
| 2000-12-17 | AnconavCagliariSerie B · Italy | 1–1 | Serie B · Italy |
| 2000-12-17 | TrabzonsporvGalatasaraySüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2000-12-17 | BoavistavSalgueirosPrimeira Liga · Portugal | 5–0 | Primeira Liga · Portugal |
| 2000-12-17 | Est AmadoravAvesPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2000-12-17 | ElchevRecreativoLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2000-12-17 | CordobavSevillaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2000-12-17 | IntervBresciaSerie A · Italy | 0–0 | Serie A · Italy |
| 2000-12-17 | LeccevJuventusSerie A · Italy | 1–4 | Serie A · Italy |
| 2000-12-17 | St PaulivAhlen2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2000-12-17 | AthinaikosvPAOKSuper League · Greece | 3–4 | Super League · Greece |
| 2000-12-17 | RoosendaalvHeerenveenEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2000-12-17 | BastiavParis SGLigue 1 · France | 1–1 | Ligue 1 · France |
| 2000-12-17 | WaalwijkvSpartaEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2000-12-17 | BenficavGil VicentePrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2000-12-17 | GenkvClub BruggePro League · Belgium | 0–1 | Pro League · Belgium |
| 2000-12-17 | CompostelavGetafeLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2000-12-17 | LaziovRomaSerie A · Italy | 0–1 | Serie A · Italy |
| 2000-12-16 | BesiktasvDenizlisporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2000-12-16 | Port ValevBristol CityLeague One · England | 1–2 | League One · England |
| 2000-12-16 | EvertonvWest HamPremier League · England | 1–1 | Premier League · England |
| 2000-12-16 | ClydevFalkirkChampionship · Scotland | 0–3 | Championship · Scotland |
| 2000-12-16 | TroyesvLyonLigue 1 · France | 1–0 | Ligue 1 · France |
| 2000-12-16 | MiddlesbroughvChelseaPremier League · England | 1–0 | Premier League · England |
| 2000-12-16 | YozgatsporvSiirt Jet-PASüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2000-12-16 | GrimsbyvNorwichChampionship · England | 2–0 | Championship · England |
| 2000-12-16 | LincolnvRochdaleLeague Two · England | 1–1 | League Two · England |