| 2011-12-26 | Fleetwood TownvSouthportNational League · England | 2–2 | National League · England |
| 2011-12-17 | SouthportvMansfieldNational League · England | 3–1 | National League · England |
| 2011-12-06 | WrexhamvSouthportNational League · England | 2–0 | National League · England |
| 2011-12-03 | SouthportvAlfreton TownNational League · England | 2–1 | National League · England |
| 2011-11-29 | SouthportvForest GreenNational League · England | 1–3 | National League · England |
| 2011-11-26 | StockportvSouthportNational League · England | 0–1 | National League · England |
| 2011-11-19 | SouthportvBath CityNational League · England | 2–1 | National League · England |
| 2011-11-05 | Kettering TownvSouthportNational League · England | 2–3 | National League · England |
| 2011-10-22 | SouthportvTamworthNational League · England | 1–1 | National League · England |
| 2011-10-18 | GatesheadvSouthportNational League · England | 2–3 | National League · England |
| 2011-10-15 | MansfieldvSouthportNational League · England | 1–3 | National League · England |
| 2011-10-11 | SouthportvYorkNational League · England | 1–1 | National League · England |
| 2011-10-08 | Newport CountyvSouthportNational League · England | 0–3 | National League · England |
| 2011-10-01 | SouthportvCambridgeNational League · England | 1–0 | National League · England |
| 2011-09-27 | DarlingtonvSouthportNational League · England | 0–3 | National League · England |
| 2011-09-24 | SouthportvBraintree TownNational League · England | 0–4 | National League · England |
| 2011-09-20 | SouthportvWrexhamNational League · England | 0–0 | National League · England |
| 2011-09-17 | Forest GreenvSouthportNational League · England | 2–3 | National League · England |
| 2011-09-10 | Bath CityvSouthportNational League · England | 1–2 | National League · England |
| 2011-09-03 | SouthportvAFC Telford UnitedNational League · England | 3–2 | National League · England |
| 2011-08-29 | SouthportvBarrowNational League · England | 2–1 | National League · England |
| 2011-08-27 | KidderminstervSouthportNational League · England | 2–0 | National League · England |
| 2011-08-23 | SouthportvGatesheadNational League · England | 1–3 | National League · England |
| 2011-08-20 | LutonvSouthportNational League · England | 5–1 | National League · England |
| 2011-08-16 | Alfreton TownvSouthportNational League · England | 0–0 | National League · England |
| 2011-08-13 | SouthportvLincolnNational League · England | 2–2 | National League · England |
| 2011-04-30 | Kettering TownvSouthportNational League · England | 3–1 | National League · England |
| 2011-04-25 | SouthportvDarlingtonNational League · England | 1–1 | National League · England |
| 2011-04-23 | TamworthvSouthportNational League · England | 0–1 | National League · England |
| 2011-04-16 | SouthportvCrawley TownNational League · England | 0–4 | National League · England |
| 2011-04-09 | LutonvSouthportNational League · England | 6–0 | National League · England |
| 2011-04-05 | MansfieldvSouthportNational League · England | 2–2 | National League · England |
| 2011-04-02 | SouthportvEastbourne BoroughNational League · England | 1–3 | National League · England |
| 2011-03-29 | AltrinchamvSouthportNational League · England | 1–1 | National League · England |
| 2011-03-26 | SouthportvLutonNational League · England | 2–1 | National League · England |
| 2011-03-19 | Rushden & DvSouthportNational League · England | 2–2 | National League · England |
| 2011-03-15 | SouthportvBarrowNational League · England | 2–4 | National League · England |
| 2011-03-12 | SouthportvCambridgeNational League · England | 1–1 | National League · England |
| 2011-03-05 | Eastbourne BoroughvSouthportNational League · England | 4–1 | National League · England |
| 2011-03-01 | SouthportvHistonNational League · England | 3–1 | National League · England |
| 2011-02-26 | Bath CityvSouthportNational League · England | 2–1 | National League · England |
| 2011-02-22 | Crawley TownvSouthportNational League · England | 1–0 | National League · England |
| 2011-02-19 | Hayes & YeadingvSouthportNational League · England | 1–0 | National League · England |
| 2011-02-12 | SouthportvForest GreenNational League · England | 4–0 | National League · England |
| 2011-02-01 | SouthportvGrimsbyNational League · England | 2–2 | National League · England |
| 2011-01-29 | SouthportvYorkNational League · England | 4–0 | National League · England |
| 2011-01-22 | AFC WimbledonvSouthportNational League · England | 5–0 | National League · England |
| 2011-01-18 | SouthportvWrexhamNational League · England | 0–1 | National League · England |
| 2011-01-08 | SouthportvNewport CountyNational League · England | 2–1 | National League · England |
| 2011-01-03 | SouthportvGatesheadNational League · England | 5–1 | National League · England |