| 2021-10-23 | GuingampvNimesLigue 2 · France | 3–1 | Ligue 2 · France |
| 2021-10-23 | Airdrie UtdvDumbartonLeague One · Scotland | 3–2 | League One · Scotland |
| 2021-10-23 | RochdalevSuttonLeague Two · England | 3–2 | League Two · England |
| 2021-10-23 | Defensa y JusticiavPlatenseLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-10-23 | West BromvBristol CityChampionship · England | 3–0 | Championship · England |
| 2021-10-23 | Cercle BruggevStandardPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-10-23 | Port ValevColchesterLeague Two · England | 3–0 | League Two · England |
| 2021-10-23 | BoltonvGillinghamLeague One · England | 2–2 | League One · England |
| 2021-10-23 | Bayern MunichvHoffenheimBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-10-23 | GrenoblevDijonLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-10-23 | AFC WimbledonvWiganLeague One · England | 0–2 | League One · England |
| 2021-10-23 | VikingvLillestromEliteserien · Norway | 5–1 | Eliteserien · Norway |
| 2021-10-23 | Gamba OsakavSagan TosuJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-10-23 | AberdeenvHibernianPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-10-23 | CelticvSt JohnstonePremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-10-23 | NurnbergvHeidenheim2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2021-10-23 | SassuolovVeneziaSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-10-23 | AjacciovNancyLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-10-23 | MaidenheadvWokingNational League · England | 3–2 | National League · England |
| 2021-10-23 | Fortuna DusseldorfvKarlsruhe2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2021-10-23 | Finn HarpsvSligo RoversPremier Division · Ireland | 2–2 | Premier Division · Ireland |
| 2021-10-23 | LeccevPerugiaSerie B · Italy | 0–0 | Serie B · Italy |
| 2021-10-23 | WycombevCreweLeague One · England | 2–1 | League One · England |
| 2021-10-23 | ArbroathvAyrChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-10-23 | Cove RangersvClydeLeague One · Scotland | 3–0 | League One · Scotland |
| 2021-10-23 | MiovenivFC BotosaniSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-10-23 | GaziantepvGiresunsporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-10-23 | UtrechtvHeerenveenEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-10-23 | KuPSvHIFKVeikkausliiga · Finland | 0–0 | Veikkausliiga · Finland |
| 2021-10-23 | Holstein KielvDarmstadt2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-10-23 | CSKA MoscowvKrylya SovetovPremier League · Russia | 3–1 | Premier League · Russia |
| 2021-10-23 | AccringtonvPortsmouthLeague One · England | 2–2 | League One · England |
| 2021-10-23 | Pogon SzczecinvJagielloniaEkstraklasa · Poland | 4–1 | Ekstraklasa · Poland |
| 2021-10-23 | DoncastervCheltenhamLeague One · England | 3–2 | League One · England |
| 2021-10-23 | Crystal PalacevNewcastlePremier League · England | 1–1 | Premier League · England |
| 2021-10-23 | GrasshoppersvZurichSuper League · Switzerland | 3–3 | Super League · Switzerland |
| 2021-10-23 | Shonan BellmarevYokohama FCJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-10-23 | Ross CountyvLivingstonPremiership · Scotland | 2–3 | Premiership · Scotland |
| 2021-10-23 | CoventryvDerbyChampionship · England | 1–1 | Championship · England |
| 2021-10-23 | BresciavCremoneseSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-10-23 | BarnetvWrexhamNational League · England | 0–3 | National League · England |
| 2021-10-23 | Sp GijonvValladolidLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-23 | AtromitosvIonikosSuper League · Greece | 0–2 | Super League · Greece |
| 2021-10-23 | SolihullvHalifaxNational League · England | 1–0 | National League · England |
| 2021-10-23 | Queen of SthvMortonChampionship · Scotland | 0–0 | Championship · Scotland |
| 2021-10-23 | StevenagevLeyton OrientLeague Two · England | 0–0 | League Two · England |
| 2021-10-23 | LeedsvWolvesPremier League · England | 1–1 | Premier League · England |
| 2021-10-23 | TokushimavOita TrinitaJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-10-23 | Gimnasia L.P.vCentral CordobaLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2021-10-23 | FC VoluntarivFC ArgesSuperliga · Romania | 0–2 | Superliga · Romania |