| 2008-09-27 | SochauxvLorientLigue 1 · France | 1–1 | Ligue 1 · France |
| 2008-09-27 | StokevChelseaPremier League · England | 0–2 | Premier League · England |
| 2008-09-27 | Dag and RedvRotherhamLeague Two · England | 1–1 | League Two · England |
| 2008-09-27 | WolvesvBristol CityChampionship · England | 2–0 | Championship · England |
| 2008-09-27 | CharleroivKortrijkPro League · Belgium | 1–2 | Pro League · Belgium |
| 2008-09-27 | ClydevQueen of SthChampionship · Scotland | 0–2 | Championship · Scotland |
| 2008-09-27 | RennesvNiceLigue 1 · France | 1–0 | Ligue 1 · France |
| 2008-09-27 | QPRvDerbyChampionship · England | 0–2 | Championship · England |
| 2008-09-27 | Milton Keynes DonsvPeterboroLeague One · England | 1–2 | League One · England |
| 2008-09-27 | VicenzavAvellinoSerie B · Italy | 3–0 | Serie B · Italy |
| 2008-09-27 | LeicestervHartlepoolLeague One · England | 1–0 | League One · England |
| 2008-09-27 | Paris SGvGrenobleLigue 1 · France | 0–1 | Ligue 1 · France |
| 2008-09-27 | BochumvLeverkusenBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2008-09-27 | Werder BremenvHoffenheimBundesliga · Germany | 5–4 | Bundesliga · Germany |
| 2008-09-27 | HerthavCottbusBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2008-09-27 | GillinghamvPort ValeLeague Two · England | 1–0 | League Two · England |
| 2008-09-27 | DortmundvStuttgartBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2008-09-27 | EvertonvLiverpoolPremier League · England | 0–2 | Premier League · England |
| 2008-09-27 | FulhamvWest HamPremier League · England | 1–2 | Premier League · England |
| 2008-09-27 | DoncastervSouthamptonChampionship · England | 0–2 | Championship · England |
| 2008-09-27 | Man UnitedvBoltonPremier League · England | 2–0 | Premier League · England |
| 2008-09-27 | BergenvRoeselarePro League · Belgium | 2–0 | Pro League · Belgium |
| 2008-09-27 | CheltenhamvStockportLeague One · England | 2–2 | League One · England |
| 2008-09-27 | LensvAngersLigue 2 · France | 3–0 | Ligue 2 · France |
| 2008-09-27 | Dundee UnitedvHeartsPremiership · Scotland | 3–0 | Premiership · Scotland |
| 2008-09-27 | AuxerrevLe HavreLigue 1 · France | 3–0 | Ligue 1 · France |
| 2008-09-27 | Sp GijonvVillarrealLa Liga · Spain | 0–1 | La Liga · Spain |
| 2008-09-27 | Sp BragavNavalPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2008-09-27 | Las PalmasvHerculesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2008-09-27 | ChateaurouxvMontpellierLigue 2 · France | 1–1 | Ligue 2 · France |
| 2008-09-27 | BurtonvForest GreenNational League · England | 4–2 | National League · England |
| 2008-09-27 | OFIvOlympiakosSuper League · Greece | 0–0 | Super League · Greece |
| 2008-09-27 | WaregemvTubizePro League · Belgium | 1–0 | Pro League · Belgium |
| 2008-09-27 | MiddlesbroughvWest BromPremier League · England | 0–1 | Premier League · England |
| 2008-09-26 | BastiavReimsLigue 2 · France | 2–2 | Ligue 2 · France |
| 2008-09-26 | StandardvAnderlechtPro League · Belgium | 2–1 | Pro League · Belgium |
| 2008-09-26 | NimesvAjaccioLigue 2 · France | 2–2 | Ligue 2 · France |
| 2008-09-26 | PortovPacos FerreiraPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2008-09-26 | SivassporvFenerbahceSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2008-09-26 | SouthendvLeyton OrientLeague One · England | 3–0 | League One · England |
| 2008-09-26 | Hansa RostockvSt Pauli2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2008-09-26 | SedanvAmiensLigue 2 · France | 0–1 | Ligue 2 · France |
| 2008-09-26 | FC KolnvSchalke 04Bundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2008-09-26 |  British Virgin Islandsv BarbadosCFU Caribbean Cup qualification | 1–2 | CFU Caribbean Cup qualification |
| 2008-09-26 | OberhausenvGreuther Furth2. Bundesliga · Germany | 0–4 | 2. Bundesliga · Germany |
| 2008-09-26 | OsnabruckvKoblenz2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2008-09-26 | BrestvBoulogneLigue 2 · France | 0–1 | Ligue 2 · France |
| 2008-09-26 | TranmerevColchesterLeague One · England | 3–4 | League One · England |
| 2008-09-25 |  Mayottev RéunionCoupe de l'Outre-Mer | 1–6 | Coupe de l'Outre-Mer |
| 2008-09-25 | RecreativovAth BilbaoLa Liga · Spain | 1–1 | La Liga · Spain |