| 2008-09-27 | BetisvReal MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2008-09-27 | BuyuksehyrvBesiktasSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2008-09-27 | MortonvDunfermlineChampionship · Scotland | 1–1 | Championship · Scotland |
| 2008-09-27 | BenficavSp LisbonPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2008-09-27 | HamburgvM'gladbachBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2008-09-27 | TrabzonsporvAntalyasporSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2008-09-27 | BuryvWycombeLeague Two · England | 0–0 | League Two · England |
| 2008-09-27 | Le MansvMarseilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2008-09-27 | DijonvMetzLigue 2 · France | 0–1 | Ligue 2 · France |
| 2008-09-27 | WalsallvCarlisleLeague One · England | 2–1 | League One · England |
| 2008-09-27 | LincolnvMorecambeLeague Two · England | 1–1 | League Two · England |
| 2008-09-27 | StirlingvPeterheadLeague One · Scotland | 0–0 | League One · Scotland |
| 2008-09-27 | IpswichvCrystal PalaceChampionship · England | 1–1 | Championship · England |
| 2008-09-27 | LivingstonvPartickChampionship · Scotland | 3–1 | Championship · Scotland |
| 2008-09-27 | NorthamptonvBrightonLeague One · England | 2–2 | League One · England |
| 2008-09-27 | SalernitanavPisaSerie B · Italy | 1–1 | Serie B · Italy |
| 2008-09-27 | PSV EindhovenvVolendamEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2008-09-27 | Club BruggevWesterloPro League · Belgium | 2–0 | Pro League · Belgium |
| 2008-09-27 | CardiffvBirminghamChampionship · England | 1–2 | Championship · England |
| 2008-09-27 | CittadellavEmpoliSerie B · Italy | 0–2 | Serie B · Italy |
| 2008-09-27 | KocaelisporvBursasporSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2008-09-27 | SalisburyvMansfieldNational League · England | 2–3 | National League · England |
| 2008-09-27 | EspanolvBarcelonaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2008-09-27 | ForfarvDumbartonLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2008-09-27 | RiminivSassuoloSerie B · Italy | 1–2 | Serie B · Italy |
| 2008-09-27 | NorthwichvWeymouthNational League · England | 2–3 | National League · England |
| 2008-09-27 | SampdoriavJuventusSerie A · Italy | 0–0 | Serie A · Italy |
| 2008-09-27 | East FifevAyrLeague One · Scotland | 3–0 | League One · Scotland |
| 2008-09-27 | BarrowvEbbsfleetNational League · England | 0–3 | National League · England |
| 2008-09-27 | Albion RvsvStenhousemuirLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2008-09-27 | LewesvOxfordNational League · England | 2–1 | National League · England |
| 2008-09-27 | TwentevGraafschapEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2008-09-27 | FalkirkvHamiltonPremiership · Scotland | 4–1 | Premiership · Scotland |
| 2008-09-27 | PlymouthvNott'm ForestChampionship · England | 1–0 | Championship · England |
| 2008-09-27 | ArsenalvHullPremier League · England | 1–2 | Premier League · England |
| 2008-09-27 | BerwickvAnnan AthleticLeague Two · Scotland | 3–0 | League Two · Scotland |
| 2008-09-27 | FiorentinavGenoaSerie A · Italy | 1–0 | Serie A · Italy |
| 2008-09-27 |  Tahitiv MartiniqueCoupe de l'Outre-Mer | 0–1 | Coupe de l'Outre-Mer |
| 2008-09-27 | CordobavGironaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2008-09-27 | East StirlingvElginLeague Two · Scotland | 5–2 | League Two · Scotland |
| 2008-09-27 | Aston VillavSunderlandPremier League · England | 2–1 | Premier League · England |
| 2008-09-27 | ScunthorpevYeovilLeague One · England | 2–0 | League One · England |
| 2008-09-27 | ReadingvSwanseaChampionship · England | 4–0 | Championship · England |
| 2008-09-27 | CelticvAberdeenPremiership · Scotland | 3–2 | Premiership · Scotland |
| 2008-09-27 | OldhamvHuddersfieldLeague One · England | 1–1 | League One · England |
| 2008-09-27 | ChesterfieldvBrentfordLeague Two · England | 0–1 | League Two · England |
| 2008-09-27 | TriestinavMantovaSerie B · Italy | 1–0 | Serie B · Italy |
| 2008-09-27 | CharltonvSheffield WedsChampionship · England | 1–2 | Championship · England |
| 2008-09-27 | Eastbourne BoroughvKidderminsterNational League · England | 2–3 | National League · England |
| 2008-09-27 | AlbinoleffevPiacenzaSerie B · Italy | 0–0 | Serie B · Italy |