| 2000-09-17 | RangersvHeartsPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2000-09-17 | SienavAnconaSerie B · Italy | 4–1 | Serie B · Italy |
| 2000-09-17 | FarensevSalgueirosPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2000-09-17 | LeganesvMurciaLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2000-09-17 | St EtiennevLilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2000-09-17 | BetisvFerrolLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2000-09-16 | OxfordvBuryLeague One · England | 1–0 | League One · England |
| 2000-09-16 | East FifevElginLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2000-09-16 | WatfordvCreweChampionship · England | 3–0 | Championship · England |
| 2000-09-16 | LiersevAntwerpPro League · Belgium | 4–1 | Pro League · Belgium |
| 2000-09-16 | HamburgvDortmundBundesliga · Germany | 2–3 | Bundesliga · Germany |
| 2000-09-16 | BrentfordvMillwallLeague One · England | 1–1 | League One · England |
| 2000-09-16 | ElchevSevillaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2000-09-16 | ForfarvClydebankLeague One · Scotland | 0–2 | League One · Scotland |
| 2000-09-16 | Ath BilbaovBarcelonaLa Liga · Spain | 3–1 | La Liga · Spain |
| 2000-09-16 | ExetervYorkLeague Two · England | 3–1 | League Two · England |
| 2000-09-16 | GillinghamvHuddersfieldChampionship · England | 2–1 | Championship · England |
| 2000-09-16 | FreiburgvCottbusBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2000-09-16 | TranmerevSheffield WedsChampionship · England | 2–0 | Championship · England |
| 2000-09-16 | LavalvNiortLigue 2 · France | 0–1 | Ligue 2 · France |
| 2000-09-16 | CreteilvCaenLigue 2 · France | 0–1 | Ligue 2 · France |
| 2000-09-16 | HartlepoolvMacclesfieldLeague Two · England | 2–2 | League Two · England |
| 2000-09-16 | BochumvWolfsburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2000-09-16 | BerwickvQueen of SthLeague One · Scotland | 0–4 | League One · Scotland |
| 2000-09-16 | LivingstonvRaith RvsChampionship · Scotland | 0–4 | Championship · Scotland |
| 2000-09-16 | ArsenalvCoventryPremier League · England | 2–1 | Premier League · England |
| 2000-09-16 | TroyesvStrasbourgLigue 1 · France | 0–1 | Ligue 1 · France |
| 2000-09-16 | SamsunsporvErzurumsporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2000-09-16 | LouvieroisevMechelenPro League · Belgium | 2–2 | Pro League · Belgium |
| 2000-09-16 | LokerenvSt TruidenPro League · Belgium | 2–1 | Pro League · Belgium |
| 2000-09-16 | LensvParis SGLigue 1 · France | 1–1 | Ligue 1 · France |
| 2000-09-16 | WasquehalvAjaccioLigue 2 · France | 2–0 | Ligue 2 · France |
| 2000-09-16 | MontrosevDumbartonLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2000-09-16 | GuingampvAuxerreLigue 1 · France | 1–0 | Ligue 1 · France |
| 2000-09-16 | Nott'm ForestvFulhamChampionship · England | 0–3 | Championship · England |
| 2000-09-16 | HalifaxvSouthendLeague Two · England | 0–1 | League Two · England |
| 2000-09-16 | LincolnvBlackpoolLeague Two · England | 1–1 | League Two · England |
| 2000-09-16 | NorwichvCrystal PalaceChampionship · England | 0–0 | Championship · England |
| 2000-09-16 | LeedsvIpswichPremier League · England | 1–2 | Premier League · England |
| 2000-09-16 | PeterborovReadingLeague One · England | 1–0 | League One · England |
| 2000-09-16 | PlymouthvCarlisleLeague Two · England | 2–0 | League Two · England |
| 2000-09-16 | DenizlisporvBursasporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2000-09-16 | HullvShrewsburyLeague Two · England | 1–0 | League Two · England |
| 2000-09-16 | MarseillevBordeauxLigue 1 · France | 0–1 | Ligue 1 · France |
| 2000-09-16 | MontpelliervSochauxLigue 2 · France | 0–2 | Ligue 2 · France |
| 2000-09-16 | StandardvAalstPro League · Belgium | 7–0 | Pro League · Belgium |
| 2000-09-16 | ColchestervWrexhamLeague One · England | 1–1 | League One · England |
| 2000-09-16 | StranraervQueens ParkLeague One · Scotland | 3–0 | League One · Scotland |
| 2000-09-16 | AnderlechtvHarelbekePro League · Belgium | 4–3 | Pro League · Belgium |
| 2000-09-16 | RotherhamvWycombeLeague One · England | 1–0 | League One · England |