| 2021-10-24 | Oud-Heverlee LeuvenvSt TruidenPro League · Belgium | 4–1 | Pro League · Belgium |
| 2021-10-24 | Chicago FirevReal Salt LakeMLS · United States | 1–0 | MLS · United States |
| 2021-10-24 | Kawasaki FrontalevShimizu S-PulseJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-10-24 | Guadalajara ChivasvCruz AzulLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-10-24 | Minnesota UnitedvLos Angeles FCMLS · United States | 1–1 | MLS · United States |
| 2021-10-24 | LorientvBordeauxLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-10-24 | ZaglebievCracoviaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-10-24 | Godoy CruzvBanfieldLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-10-24 | RegensburgvHannover2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2021-10-24 | RosenborgvSandefjordEliteserien · Norway | 4–1 | Eliteserien · Norway |
| 2021-10-24 | Randers FCvAarhusSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2021-10-24 | AmorebietavSociedad BLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-24 | BochumvEin FrankfurtBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-10-24 | HartbergvSK RapidBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-10-24 | Colorado RapidsvPortland TimbersMLS · United States | 2–0 | MLS · United States |
| 2021-10-24 | Akhmat GroznyvUralPremier League · Russia | 1–0 | Premier League · Russia |
| 2021-10-24 | VarbergvMalmo FFAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-10-24 | Ath MadridvSociedadLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-10-24 | Queens ParkvAlloaLeague One · Scotland | 3–4 | League One · Scotland |
| 2021-10-24 | Piast GliwicevLegiaEkstraklasa · Poland | 4–1 | Ekstraklasa · Poland |
| 2021-10-24 | Austin FCvHouston DynamoMLS · United States | 2–1 | MLS · United States |
| 2021-10-24 | UfavRubin KazanPremier League · Russia | 1–1 | Premier League · Russia |
| 2021-10-24 | Cerezo OsakavYokohama F. MarinosJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-10-24 | West HamvTottenhamPremier League · England | 1–0 | Premier League · England |
| 2021-10-24 | GenkvGentPro League · Belgium | 0–3 | Pro League · Belgium |
| 2021-10-24 | LASKvAltachBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-10-24 | Volos NFCvAEKSuper League · Greece | 1–3 | Super League · Greece |
| 2021-10-24 | Colon Santa FEvEstudiantes L.P.Liga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-10-24 | HJKvInter TurkuVeikkausliiga · Finland | 2–1 | Veikkausliiga · Finland |
| 2021-10-24 | SpalvComoSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-10-24 | Nott'm ForestvFulhamChampionship · England | 0–4 | Championship · England |
| 2021-10-24 | MarseillevParis SGLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-10-24 | AnderlechtvBeerschot VAPro League · Belgium | 4–2 | Pro League · Belgium |
| 2021-10-24 |  MonacovMontpellierLigue 1 · France | 3–1 | Ligue 1 · France |
| 2021-10-24 | Pacos FerreiravAroucaPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-10-24 | DroghedavDerry CityPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2021-10-24 | Club AmericavTigres UANLLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-10-24 | SalzburgvSturm GrazBundesliga · Austria | 4–1 | Bundesliga · Austria |
| 2021-10-24 | InternacionalvCorinthiansSerie A · Brazil | 2–2 | Serie A · Brazil |
| 2021-10-24 | St PaulivHansa Rostock2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2021-10-24 | AntwerpvClub BruggePro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-10-24 | StromsgodsetvBodo/GlimtEliteserien · Norway | 1–1 | Eliteserien · Norway |
| 2021-10-24 | ReimsvTroyesLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-10-24 | KristiansundvSarpsborg 08Eliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2021-10-24 | MidtjyllandvSonderjyskeSuperliga · Denmark | 3–2 | Superliga · Denmark |
| 2021-10-24 | PortimonensevEstorilPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2021-10-24 | New York CityvDC UnitedMLS · United States | 6–0 | MLS · United States |
| 2021-10-24 | HammarbyvOstersundsAllsvenskan · Sweden | 4–3 | Allsvenskan · Sweden |
| 2021-10-24 | BaselvLuganoSuper League · Switzerland | 2–0 | Super League · Switzerland |
| 2021-10-23 | SunderlandvCharltonLeague One · England | 0–1 | League One · England |