| 2010-09-22 | Club BruggevEupenPro League · Belgium | 4–0 | Pro League · Belgium |
| 2010-09-22 | NapolivChievoSerie A · Italy | 1–3 | Serie A · Italy |
| 2010-09-22 | LeverkusenvEin FrankfurtBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-09-22 | DuisburgvAugsburg2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2010-09-22 | OsnabruckvUnion Berlin2. Bundesliga · Germany | 4–1 | 2. Bundesliga · Germany |
| 2010-09-22 | NurnbergvStuttgartBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2010-09-22 | CagliarivSampdoriaSerie A · Italy | 0–0 | Serie A · Italy |
| 2010-09-22 | LokerenvGentPro League · Belgium | 3–2 | Pro League · Belgium |
| 2010-09-22 | CataniavCesenaSerie A · Italy | 2–0 | Serie A · Italy |
| 2010-09-22 | MechelenvCercle BruggePro League · Belgium | 2–2 | Pro League · Belgium |
| 2010-09-22 | StandardvCharleroiPro League · Belgium | 2–1 | Pro League · Belgium |
| 2010-09-22 | ZaragozavHerculesLa Liga · Spain | 0–0 | La Liga · Spain |
| 2010-09-22 | BresciavRomaSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-09-22 | GenoavFiorentinaSerie A · Italy | 1–1 | Serie A · Italy |
| 2010-09-22 | Munich 1860vErzgebirge Aue2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2010-09-22 | DortmundvKaiserslauternBundesliga · Germany | 5–0 | Bundesliga · Germany |
| 2010-09-22 |  French Guianav MayotteCoupe de l'Outre-Mer | 2–2 p | Coupe de l'Outre-Mer |
| 2010-09-22 |  Réunionv Saint Pierre and MiquelonCoupe de l'Outre-Mer | 11–0 | Coupe de l'Outre-Mer |
| 2010-09-22 | HamburgvWolfsburgBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2010-09-22 | M'gladbachvSt PauliBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2010-09-22 | IngolstadtvFortuna Dusseldorf2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2010-09-22 | ValenciavAth MadridLa Liga · Spain | 1–1 | La Liga · Spain |
| 2010-09-22 | LaziovMilanSerie A · Italy | 1–1 | Serie A · Italy |
| 2010-09-22 | KortrijkvWesterloPro League · Belgium | 1–2 | Pro League · Belgium |
| 2010-09-22 | IntervBariSerie A · Italy | 4–0 | Serie A · Italy |
| 2010-09-22 | BolognavUdineseSerie A · Italy | 2–1 | Serie A · Italy |
| 2010-09-22 | LiersevAnderlechtPro League · Belgium | 1–1 | Pro League · Belgium |
| 2010-09-22 | BarcelonavSp GijonLa Liga · Spain | 1–0 | La Liga · Spain |
| 2010-09-21 | HoffenheimvBayern MunichBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2010-09-21 | Frankfurt FSVvAachen2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2010-09-21 | Ath BilbaovMallorcaLa Liga · Spain | 3–0 | La Liga · Spain |
| 2010-09-21 | WrexhamvSouthportNational League · England | 2–1 | National League · England |
| 2010-09-21 | OsasunavSociedadLa Liga · Spain | 3–1 | La Liga · Spain |
| 2010-09-21 |  Saint Luciav Trinidad and TobagoFriendly | 0–3 | Friendly |
| 2010-09-21 |  Iraqv OmanFriendly | 3–2 | Friendly |
| 2010-09-21 | CottbusvGreuther Furth2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2010-09-21 | HerthavKarlsruhe2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2010-09-21 | PaderbornvOberhausen2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2010-09-21 | GatesheadvGrimsbyNational League · England | 0–0 | National League · England |
| 2010-09-21 | DarlingtonvLutonNational League · England | 2–2 | National League · England |
| 2010-09-21 | Dag and RedvExeterLeague One · England | 1–1 | League One · England |
| 2010-09-21 | TamworthvBath CityNational League · England | 2–2 | National League · England |
| 2010-09-21 | AltrinchamvBarrowNational League · England | 2–0 | National League · England |
| 2010-09-21 | Forest GreenvEastbourne BoroughNational League · England | 3–4 | National League · England |
| 2010-09-21 | MainzvFC KolnBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2010-09-21 | HannovervWerder BremenBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2010-09-21 | Hayes & YeadingvNewport CountyNational League · England | 1–2 | National League · England |
| 2010-09-21 | CambridgevKettering TownNational League · England | 3–0 | National League · England |
| 2010-09-21 | PlymouthvBrightonLeague One · England | 0–2 | League One · England |
| 2010-09-21 | Real MadridvEspanolLa Liga · Spain | 3–0 | La Liga · Spain |