| 2008-09-28 | SalamancavCastellonLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2008-09-28 | PanioniosvAEKSuper League · Greece | 2–2 | Super League · Greece |
| 2008-09-28 | SantandervMallorcaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2008-09-28 | MilanvInterSerie A · Italy | 1–0 | Serie A · Italy |
| 2008-09-28 | Den HaagvUtrechtEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2008-09-28 | HacettepesporvAnkaragucuSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2008-09-28 | BolognavNapoliSerie A · Italy | 0–1 | Serie A · Italy |
| 2008-09-28 | GaziantepsporvDenizlisporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2008-09-28 | AugsburgvMainz2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2008-09-27 | Queens ParkvAlloaLeague One · Scotland | 1–0 | League One · Scotland |
| 2008-09-27 | LokerenvCercle BruggePro League · Belgium | 1–1 | Pro League · Belgium |
| 2008-09-27 | Crawley TownvKettering TownNational League · England | 1–0 | National League · England |
| 2008-09-27 | BlackpoolvCoventryChampionship · England | 1–1 | Championship · England |
| 2008-09-27 | NewcastlevBlackburnPremier League · England | 1–2 | Premier League · England |
| 2008-09-27 | LutonvChesterLeague Two · England | 1–1 | League Two · England |
| 2008-09-27 | CaenvNantesLigue 1 · France | 3–0 | Ligue 1 · France |
| 2008-09-27 | St JohnstonevDundeeChampionship · Scotland | 2–0 | Championship · Scotland |
| 2008-09-27 | VannesvGuingampLigue 2 · France | 0–0 | Ligue 2 · France |
| 2008-09-27 | WrexhamvTorquayNational League · England | 1–1 | National League · England |
| 2008-09-27 | ZaragozavMurciaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2008-09-27 | Sheffield UnitedvWatfordChampionship · England | 2–1 | Championship · England |
| 2008-09-27 | SetubalvRio AvePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2008-09-27 | SociedadvAlavesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2008-09-27 | BrechinvRaith RvsLeague One · Scotland | 2–0 | League One · Scotland |
| 2008-09-27 | PanserraikosvLarisaSuper League · Greece | 1–3 | Super League · Greece |
| 2008-09-27 | BournemouthvDarlingtonLeague Two · England | 3–1 | League Two · England |
| 2008-09-27 | ModenavTrevisoSerie B · Italy | 1–1 | Serie B · Italy |
| 2008-09-27 | Bristol RvsvCreweLeague One · England | 0–0 | League One · England |
| 2008-09-27 | MacclesfieldvExeterLeague Two · England | 1–4 | League Two · England |
| 2008-09-27 | HannovervBayern MunichBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2008-09-27 | NAC BredavHeerenveenEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2008-09-27 | CowdenbeathvMontroseLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2008-09-27 |  New Caledoniav GuadeloupeCoupe de l'Outre-Mer | 0–4 | Coupe de l'Outre-Mer |
| 2008-09-27 | BurnleyvPrestonChampionship · England | 3–1 | Championship · England |
| 2008-09-27 | LyonvNancyLigue 1 · France | 2–1 | Ligue 1 · France |
| 2008-09-27 | ShrewsburyvBradfordLeague Two · England | 2–0 | League Two · England |
| 2008-09-27 | GenclerbirligivAnkarasporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2008-09-27 | StranraervArbroathLeague One · Scotland | 2–2 | League One · Scotland |
| 2008-09-27 | Notts CountyvAldershotLeague Two · England | 2–1 | League Two · England |
| 2008-09-27 | Inverness CvKilmarnockPremiership · Scotland | 3–1 | Premiership · Scotland |
| 2008-09-27 | Ross CountyvAirdrie UtdChampionship · Scotland | 2–0 | Championship · Scotland |
| 2008-09-27 | AscolivBariSerie B · Italy | 0–1 | Serie B · Italy |
| 2008-09-27 | LivornovGrossetoSerie B · Italy | 0–0 | Serie B · Italy |
| 2008-09-27 | GrimsbyvBarnetLeague Two · England | 0–1 | League Two · England |
| 2008-09-27 | BarnsleyvNorwichChampionship · England | 0–0 | Championship · England |
| 2008-09-27 | MotherwellvSt MirrenPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2008-09-27 | LeedsvHerefordLeague One · England | 1–0 | League One · England |
| 2008-09-27 | TroyesvToursLigue 2 · France | 3–2 | Ligue 2 · France |
| 2008-09-27 | Willem IIvAZ AlkmaarEredivisie · Netherlands | 2–5 | Eredivisie · Netherlands |
| 2008-09-27 | WokingvHistonNational League · England | 1–0 | National League · England |