| 2000-09-18 | OFIvArisSuper League · Greece | 2–3 | Super League · Greece |
| 2000-09-18 | AEKvIraklisSuper League · Greece | 2–0 | Super League · Greece |
| 2000-09-17 | KalamatavPAOKSuper League · Greece | 0–0 | Super League · Greece |
| 2000-09-17 | Greuther FurthvOberhausen2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2000-09-17 | NijmegenvFor SittardEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2000-09-17 | GetafevTenerifeLa Liga 2 · Spain | 0–5 | La Liga 2 · Spain |
| 2000-09-17 | EmpolivGenoaSerie B · Italy | 0–0 | Serie B · Italy |
| 2000-09-17 | VallecanovZaragozaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2000-09-17 | VitessevWaalwijkEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2000-09-17 | HerthavStuttgartBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2000-09-17 | IonikosvAthinaikosSuper League · Greece | 1–0 | Super League · Greece |
| 2000-09-17 | UtrechtvTwenteEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2000-09-17 | Siirt Jet-PAvAnkaragucuSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2000-09-17 | NantesvLyonLigue 1 · France | 0–1 | Ligue 1 · France |
| 2000-09-17 | CosenzavCrotoneSerie B · Italy | 3–0 | Serie B · Italy |
| 2000-09-17 | AlavesvVillarrealLa Liga · Spain | 0–1 | La Liga · Spain |
| 2000-09-17 | LleidavSalamancaLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2000-09-17 | Sp GijonvExtremaduraLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2000-09-17 | SaarbruckenvOsnabruck2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2000-09-17 | Port ValevStokeLeague One · England | 1–1 | League One · England |
| 2000-09-17 | OviedovLas PalmasLa Liga · Spain | 2–2 | La Liga · Spain |
| 2000-09-17 | Man CityvMiddlesbroughPremier League · England | 1–1 | Premier League · England |
| 2000-09-17 | EspanolvOsasunaLa Liga · Spain | 1–2 | La Liga · Spain |
| 2000-09-17 | AZ AlkmaarvAjaxEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2000-09-17 | MaritimovAvesPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2000-09-17 | Stuttgarter KvNurnberg2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2000-09-17 | RoosendaalvGroningenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2000-09-17 | GueugnonvChateaurouxLigue 2 · France | 0–1 | Ligue 2 · France |
| 2000-09-17 | YozgatsporvAdanasporSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2000-09-17 | Schalke 04vWerder BremenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2000-09-17 | CagliarivPescaraSerie B · Italy | 2–1 | Serie B · Italy |
| 2000-09-17 | CeltavSociedadLa Liga · Spain | 4–1 | La Liga · Spain |
| 2000-09-17 | GerminalvClub BruggePro League · Belgium | 2–3 | Pro League · Belgium |
| 2000-09-17 | CittadellavTernanaSerie B · Italy | 3–1 | Serie B · Italy |
| 2000-09-17 | GenkvCharleroiPro League · Belgium | 2–1 | Pro League · Belgium |
| 2000-09-17 | ChelseavLeicesterPremier League · England | 0–2 | Premier League · England |
| 2000-09-17 | LevantevU.Las PalmasLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2000-09-17 | PanahaikivXanthiSuper League · Greece | 1–1 | Super League · Greece |
| 2000-09-17 | GenclerbirligivGaziantepsporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2000-09-17 | JaenvAth MadridLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2000-09-17 | CompostelavBadajozLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2000-09-17 | West HamvLiverpoolPremier League · England | 1–1 | Premier League · England |
| 2000-09-17 | AntalyasporvRizesporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2000-09-17 | Pacos FerreiravBeira MarPrimeira Liga · Portugal | 3–2 | Primeira Liga · Portugal |
| 2000-09-17 | ChemnitzvUlm2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2000-09-17 | IstanbulsporvTrabzonsporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2000-09-17 | PaniliakosvPanioniosSuper League · Greece | 1–1 | Super League · Greece |
| 2000-09-17 | BelenensesvLeiriaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2000-09-17 | West BromvBirminghamChampionship · England | 1–1 | Championship · England |
| 2000-09-17 | RecreativovCordobaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |