| 2021-10-24 | Warta PoznanvStal MielecEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-10-24 | Toronto FCvCF MontrealMLS · United States | 1–1 | MLS · United States |
| 2021-10-24 | Los Angeles GalaxyvFC DallasMLS · United States | 2–2 | MLS · United States |
| 2021-10-24 | MjallbyvGoteborgAllsvenskan · Sweden | 1–3 | Allsvenskan · Sweden |
| 2021-10-24 | Man UnitedvLiverpoolPremier League · England | 0–5 | Premier League · England |
| 2021-10-24 | UNAM PumasvClub TijuanaLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2021-10-24 | IntervJuventusSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-10-24 | BetisvVallecanoLa Liga · Spain | 3–2 | La Liga · Spain |
| 2021-10-24 | BarcelonavReal MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-10-24 | BragantinovSao PauloSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-10-24 | BurgosvHuescaLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-10-24 | St MirrenvRangersPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-10-24 | OFI CretevLamiaSuper League · Greece | 0–0 | Super League · Greece |
| 2021-10-24 | VizelavBenficaPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-10-24 | ArisvPanetolikosSuper League · Greece | 5–1 | Super League · Greece |
| 2021-10-24 | San Jose EarthquakesvVancouver WhitecapsMLS · United States | 1–1 | MLS · United States |
| 2021-10-24 | ZenitvSpartak MoscowPremier League · Russia | 7–1 | Premier League · Russia |
| 2021-10-24 | PonferradinavOviedoLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-10-24 | FenerbahcevAlanyasporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-10-24 | Las PalmasvAlcorconLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2021-10-24 | OddvBrannEliteserien · Norway | 3–3 | Eliteserien · Norway |
| 2021-10-24 | Rosario CentralvRacing ClubLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-10-24 | Hokkaido Consadole SapporovAvispa FukuokaJ1 League · Japan | 0–0 | J1 League · Japan |
| 2021-10-24 | SevillavLevanteLa Liga · Spain | 5–3 | La Liga · Spain |
| 2021-10-24 | SivassporvAd. DemirsporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-10-24 | PisavPordenoneSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-10-24 | BrentfordvLeicesterPremier League · England | 1–2 | Premier League · England |
| 2021-10-24 | ServettevSionSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2021-10-24 | SandhausenvWerder Bremen2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2021-10-24 | MirandesvAlmeriaLa Liga 2 · Spain | 1–4 | La Liga 2 · Spain |
| 2021-10-24 | SilkeborgvOdenseSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-10-24 | NicevLyonLigue 1 · France | 3–2 | Ligue 1 · France |
| 2021-10-24 | OlympiakosvPAOKSuper League · Greece | 2–1 | Super League · Greece |
| 2021-10-24 | ElfsborgvSiriusAllsvenskan · Sweden | 3–0 | Allsvenskan · Sweden |
| 2021-10-24 | VeronavLazioSerie A · Italy | 4–1 | Serie A · Italy |
| 2021-10-24 | RegginavParmaSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-10-24 | FiorentinavCagliariSerie A · Italy | 3–0 | Serie A · Italy |
| 2021-10-24 | BarnsleyvSheffield UnitedChampionship · England | 2–3 | Championship · England |
| 2021-10-24 | AtalantavUdineseSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-10-24 | TromsovMjondalenEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2021-10-24 | KaragumrukvHataysporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-10-24 | CambuurvFeyenoordEredivisie · Netherlands | 2–3 | Eredivisie · Netherlands |
| 2021-10-24 | HuracanvSan LorenzoLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-10-24 | BrondbyvFC CopenhagenSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-10-24 | RennesvStrasbourgLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-10-24 | Nagoya GrampusvVissel KobeJ1 League · Japan | 2–2 | J1 League · Japan |
| 2021-10-24 | AntalyasporvBuyuksehyrSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-10-24 | AIKvNorrkopingAllsvenskan · Sweden | 1–0 | Allsvenskan · Sweden |
| 2021-10-24 | FC KolnvLeverkusenBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-10-24 | LuzernvSt. GallenSuper League · Switzerland | 2–0 | Super League · Switzerland |