| 2008-09-28 | CataniavChievoSerie A · Italy | 1–0 | Serie A · Italy |
| 2008-09-28 |  French Guianav MayotteCoupe de l'Outre-Mer | 4–2 | Coupe de l'Outre-Mer |
| 2008-09-28 | IraklisvPanthrakikosSuper League · Greece | 0–0 | Super League · Greece |
| 2008-09-28 | RomavAtalantaSerie A · Italy | 2–0 | Serie A · Italy |
| 2008-09-28 | LeccevCagliariSerie A · Italy | 2–0 | Serie A · Italy |
| 2008-09-28 | PortsmouthvTottenhamPremier League · England | 2–0 | Premier League · England |
| 2008-09-28 | TorinovLazioSerie A · Italy | 1–3 | Serie A · Italy |
| 2008-09-28 | StevenagevYorkNational League · England | 3–3 | National League · England |
| 2008-09-28 | LevantevSevilla BLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2008-09-28 | MaritimovAcademicaPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2008-09-28 | Ath BilbaovGetafeLa Liga · Spain | 0–1 | La Liga · Spain |
| 2008-09-28 | VallecanovXerezLa Liga 2 · Spain | 3–3 | La Liga 2 · Spain |
| 2008-09-28 | WehenvAhlen2. Bundesliga · Germany | 1–3 | 2. Bundesliga · Germany |
| 2008-09-28 | AlbacetevGimnasticLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2008-09-28 | KaiserslauternvFrankfurt FSV2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2008-09-28 | SpartavRoda JCEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2008-09-28 | ElchevHuescaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2008-09-28 | AachenvFreiburg2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2008-09-28 | AccringtonvRochdaleLeague Two · England | 1–3 | League Two · England |
| 2008-09-28 | HibernianvRangersPremiership · Scotland | 0–3 | Premiership · Scotland |
| 2008-09-28 | TrofensevGuimaraesPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2008-09-28 | KayserisporvEskisehirsporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2008-09-28 | BordeauxvSt EtienneLigue 1 · France | 1–1 | Ligue 1 · France |
| 2008-09-28 | LevadeiakosvAsteras TripolisSuper League · Greece | 1–0 | Super League · Greece |
| 2008-09-28 | GroningenvFeyenoordEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2008-09-28 |  Saint Kitts and Nevisv BarbadosCFU Caribbean Cup qualification | 1–3 | CFU Caribbean Cup qualification |
| 2008-09-28 | AlmeriavRecreativoLa Liga · Spain | 1–0 | La Liga · Spain |
| 2008-09-28 | WiganvMan CityPremier League · England | 2–1 | Premier League · England |
| 2008-09-28 | SwindonvMillwallLeague One · England | 1–2 | League One · England |
| 2008-09-28 | ValenciennesvToulouseLigue 1 · France | 0–1 | Ligue 1 · France |
| 2008-09-28 | UdinesevSienaSerie A · Italy | 2–1 | Serie A · Italy |
| 2008-09-28 | Munich 1860vIngolstadt2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2008-09-28 | GerminalvGentPro League · Belgium | 2–2 | Pro League · Belgium |
| 2008-09-28 | AjaxvVitesseEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2008-09-28 | NijmegenvHeraclesEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2008-09-28 | MalagavValladolidLa Liga · Spain | 2–1 | La Liga · Spain |
| 2008-09-28 | NacionalvEst AmadoraPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2008-09-28 | NumanciavOsasunaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2008-09-28 | ValenciavLa CorunaLa Liga · Spain | 4–2 | La Liga · Spain |
| 2008-09-28 | Ath MadridvSevillaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2008-09-28 | GalatasarayvKonyasporSüper Lig · Turkey | 4–1 | Süper Lig · Turkey |
| 2008-09-28 | CeltavTenerifeLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2008-09-28 | PalermovRegginaSerie A · Italy | 1–0 | Serie A · Italy |
| 2008-09-28 | PAOKvArisSuper League · Greece | 1–0 | Super League · Greece |
| 2008-09-28 | MouscronvGenkPro League · Belgium | 1–2 | Pro League · Belgium |
| 2008-09-28 | Ein FrankfurtvBielefeldBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2008-09-28 | CambridgevGraysNational League · England | 1–0 | National League · England |
| 2008-09-28 | AlicantevEibarLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2008-09-28 |  MonacovLilleLigue 1 · France | 0–2 | Ligue 1 · France |
| 2008-09-28 | XanthivThrasyvoulosSuper League · Greece | 1–0 | Super League · Greece |