| 2021-10-26 | AltrinchamvSolihullNational League · England | 1–2 | National League · England |
| 2021-10-26 | MaidenheadvWrexhamNational League · England | 3–2 | National League · England |
| 2021-10-26 | DunfermlinevRaith RvsChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-10-26 | AlavesvElcheLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-10-26 | AldershotvWeymouthNational League · England | 0–2 | National League · England |
| 2021-10-26 | PalmeirasvSport RecifeSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-10-26 | WiganvLincolnLeague One · England | 1–2 | League One · England |
| 2021-10-26 | SpeziavGenoaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-10-26 | StockportvBarnetNational League · England | 1–2 | National League · England |
| 2021-10-26 | WealdstonevGrimsbyNational League · England | 1–0 | National League · England |
| 2021-10-26 | IndependientevUnion de Santa FeLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-10-26 | Atletico GOvGremioSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-10-26 | VillarrealvCadizLa Liga · Spain | 3–3 | La Liga · Spain |
| 2021-10-26 | Inverness CvArbroathChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-10-26 | ColchestervSuttonLeague Two · England | 1–3 | League Two · England |
| 2021-10-25 | PachucavJuarezLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-10-25 | Santos LagunavTolucaLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2021-10-25 | Orlando CityvNew England RevolutionMLS · United States | 2–2 | MLS · United States |
| 2021-10-25 | Gil VicentevSp BragaPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-10-25 | AldosivivArsenal SarandiLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-10-25 | BohemiansvWaterfordPremier Division · Ireland | 1–2 | Premier Division · Ireland |
| 2021-10-25 | AuxerrevBastiaLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-10-25 | LanusvTalleres CordobaLiga Profesional · Argentina | 3–3 | Liga Profesional · Argentina |
| 2021-10-25 | River PlatevArgentinos JrsLiga Profesional · Argentina | 3–0 | Liga Profesional · Argentina |
| 2021-10-25 | Lokomotiv MoscowvSochiPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-10-25 | GironavZaragozaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-10-25 | CFR ClujvSepsi Sf. GheorgheSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-10-25 | BahiavChapecoense-SCSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2021-10-25 | Sarmiento JuninvNewells Old BoysLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2021-10-25 | GetafevCeltaLa Liga · Spain | 0–3 | La Liga · Spain |
| 2021-10-25 | Atl. San LuisvAtlasLiga MX · Mexico | 2–6 | Liga MX · Mexico |
| 2021-10-25 | OrebrovDegerforsAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-10-25 | Atl. TucumanvPatronatoLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2021-10-25 | BesiktasvGalatasaraySüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-10-25 | Velez SarsfieldvBoca JuniorsLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-10-25 | St. PatricksvDundalkPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2021-10-25 | AalborgvViborgSuperliga · Denmark | 2–5 | Superliga · Denmark |
| 2021-10-25 | BoavistavBelenensesPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-10-25 | Academica ClincenivUTA AradSuperliga · Romania | 0–3 | Superliga · Romania |
| 2021-10-24 | RomavNapoliSerie A · Italy | 0–0 | Serie A · Italy |
| 2021-10-24 | TwentevNijmegenEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-10-24 | Philadelphia UnionvNashville SCMLS · United States | 1–0 | MLS · United States |
| 2021-10-24 | ValerengavHaugesundEliteserien · Norway | 2–1 | Eliteserien · Norway |
| 2021-10-24 | Atletico-MGvCuiabaSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-10-24 | StuttgartvUnion BerlinBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-10-24 | AjaxvPSV EindhovenEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |
| 2021-10-24 | LensvMetzLigue 1 · France | 4–1 | Ligue 1 · France |
| 2021-10-24 | VitessevGo Ahead EaglesEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2021-10-24 | GroningenvAZ AlkmaarEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2021-10-24 | Inter MiamivFC CincinnatiMLS · United States | 5–1 | MLS · United States |