| 2017-10-22 | Real Salt LakevSporting Kansas CityMLS · United States | 2–1 | MLS · United States |
| 2017-10-22 | VillarrealvLas PalmasLa Liga · Spain | 4–0 | La Liga · Spain |
| 2017-10-22 | PSV EindhovenvHeraclesEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2017-10-22 | TorinovRomaSerie A · Italy | 0–1 | Serie A · Italy |
| 2017-10-22 | New York CityvColumbus CrewMLS · United States | 2–2 | MLS · United States |
| 2017-10-22 | Asteras TripolisvPanioniosSuper League · Greece | 0–1 | Super League · Greece |
| 2017-10-22 | IpswichvNorwichChampionship · England | 0–1 | Championship · England |
| 2017-10-22 | Atlanta UtdvToronto FCMLS · United States | 2–2 | MLS · United States |
| 2017-10-22 | FC DallasvLos Angeles GalaxyMLS · United States | 5–1 | MLS · United States |
| 2017-10-22 | FCSBvPoli TimisoaraSuperliga · Romania | 7–0 | Superliga · Romania |
| 2017-10-22 | AstravFC VoluntariSuperliga · Romania | 2–3 | Superliga · Romania |
| 2017-10-22 | LeganesvAth BilbaoLa Liga · Spain | 1–0 | La Liga · Spain |
| 2017-10-22 | MilanvGenoaSerie A · Italy | 0–0 | Serie A · Italy |
| 2017-10-22 | Urawa RedsvGamba OsakaJ1 League · Japan | 3–3 | J1 League · Japan |
| 2017-10-22 | VallecanovSp GijonLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2017-10-22 | SpalvSassuoloSerie A · Italy | 0–1 | Serie A · Italy |
| 2017-10-22 | GoteborgvOstersundsAllsvenskan · Sweden | 0–1 | Allsvenskan · Sweden |
| 2017-10-22 | UNAM PumasvMonterreyLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2017-10-22 | SivassporvBursasporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2017-10-22 | MarseillevParis SGLigue 1 · France | 2–2 | Ligue 1 · France |
| 2017-10-22 | TondelavBelenensesPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2017-10-22 | WaregemvWaasland-BeverenPro League · Belgium | 2–5 | Pro League · Belgium |
| 2017-10-22 | AvesvBenficaPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2017-10-22 | GimnasticvAlcorconLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2017-10-22 | Tigres UANLvTolucaLiga MX · Mexico | 3–0 | Liga MX · Mexico |
| 2017-10-22 | St. GallenvLausanneSuper League · Switzerland | 0–4 | Super League · Switzerland |
| 2017-10-22 | Athletico-PRvSport RecifeSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2017-10-22 | FC CopenhagenvAarhusSuperliga · Denmark | 4–0 | Superliga · Denmark |
| 2017-10-22 | Guangzhou EvergrandevGuizhou ZhichengSuper League · China | 5–1 | Super League · China |
| 2017-10-22 | AZ AlkmaarvUtrechtEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2017-10-22 | BahiavVitoriaSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2017-10-22 | HeerenveenvVitesseEredivisie · Netherlands | 0–4 | Eredivisie · Netherlands |
| 2017-10-22 | KaiserslauternvDuisburg2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2017-10-22 | Sp LisbonvChavesPrimeira Liga · Portugal | 5–1 | Primeira Liga · Portugal |
| 2017-10-22 | EvertonvArsenalPremier League · England | 2–5 | Premier League · England |
| 2017-10-22 | LyngbyvOdenseSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2017-10-22 | CSKA MoscowvZenitPremier League · Russia | 0–0 | Premier League · Russia |
| 2017-10-22 | AnderlechtvGenkPro League · Belgium | 0–1 | Pro League · Belgium |
| 2017-10-22 | DjurgardenvHackenAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2017-10-22 | SandefjordvStromsgodsetEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2017-10-22 | MoldevHaugesundEliteserien · Norway | 1–0 | Eliteserien · Norway |
| 2017-10-22 | WislavLegiaEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2017-10-22 | NurnbergvDresden2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2017-10-22 | PachucavPueblaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2017-10-22 | FreiburgvHerthaBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2017-10-22 | VikingvValerengaEliteserien · Norway | 1–7 | Eliteserien · Norway |
| 2017-10-22 | Ponte PretavAvaiSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2017-10-22 | SionvLuganoSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2017-10-22 | Austria ViennavSK RapidBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2017-10-22 | UdinesevJuventusSerie A · Italy | 2–6 | Serie A · Italy |