| 2016-10-22 | SalernitanavVirtus EntellaSerie B · Italy | 1–1 | Serie B · Italy |
| 2016-10-22 | BournemouthvTottenhamPremier League · England | 0–0 | Premier League · England |
| 2016-10-22 | ArsenalvMiddlesbroughPremier League · England | 0–0 | Premier League · England |
| 2016-10-22 | FalkirkvRaith RvsChampionship · Scotland | 2–4 | Championship · Scotland |
| 2016-10-22 | ValenciavBarcelonaLa Liga · Spain | 2–3 | La Liga · Spain |
| 2016-10-22 | WycombevBarnetLeague Two · England | 0–2 | League Two · England |
| 2016-10-22 | Sheffield WedsvQPRChampionship · England | 1–0 | Championship · England |
| 2016-10-22 | Kashiwa ReysolvSagan TosuJ1 League · Japan | 2–3 | J1 League · Japan |
| 2016-10-22 | GranadavSp GijonLa Liga · Spain | 0–0 | La Liga · Spain |
| 2016-10-22 | Cruz AzulvPueblaLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2016-10-22 | Airdrie UtdvQueens ParkLeague One · Scotland | 4–1 | League One · Scotland |
| 2016-10-22 | Racing ClubvArsenal SarandiLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2016-10-22 | Sturm GrazvMattersburgBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2016-10-22 | LutonvMansfieldLeague Two · England | 1–1 | League Two · England |
| 2016-10-22 | NewcastlevIpswichChampionship · England | 3–0 | Championship · England |
| 2016-10-22 | TernanavCesenaSerie B · Italy | 1–1 | Serie B · Italy |
| 2016-10-22 | VaduzvThunSuper League · Switzerland | 2–3 | Super League · Switzerland |
| 2016-10-22 | SandhausenvSt Pauli2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2016-10-22 | HeidenheimvDresden2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2016-10-22 | VeronavPro VercelliSerie B · Italy | 3–0 | Serie B · Italy |
| 2016-10-22 | SouthportvSuttonNational League · England | 1–1 | National League · England |
| 2016-10-22 | Dundee UnitedvDumbartonChampionship · Scotland | 2–1 | Championship · Scotland |
| 2016-10-22 | GalatasarayvTrabzonsporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2016-10-22 | AEKvPanioniosSuper League · Greece | 0–0 | Super League · Greece |
| 2016-10-22 | RiedvWolfsberger ACBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2016-10-22 | Malmo FFvOstersundsAllsvenskan · Sweden | 0–3 | Allsvenskan · Sweden |
| 2016-10-22 | LegiavLech PoznanEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2016-10-22 | BordeauxvNancyLigue 1 · France | 1–1 | Ligue 1 · France |
| 2016-10-22 | SwanseavWatfordPremier League · England | 0–0 | Premier League · England |
| 2016-10-22 | PortovAroucaPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2016-10-22 | TorquayvAldershotNational League · England | 0–0 | National League · England |
| 2016-10-22 | NantesvRennesLigue 1 · France | 1–2 | Ligue 1 · France |
| 2016-10-22 | VallecanovGironaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2016-10-22 | StranraervEast FifeLeague One · Scotland | 1–1 | League One · Scotland |
| 2016-10-22 | DunfermlinevHibernianChampionship · Scotland | 1–3 | Championship · Scotland |
| 2016-10-22 | WesterlovCharleroiPro League · Belgium | 0–0 | Pro League · Belgium |
| 2016-10-22 | IngolstadtvDortmundBundesliga · Germany | 3–3 | Bundesliga · Germany |
| 2016-10-22 | Bristol CityvBlackburnChampionship · England | 1–0 | Championship · England |
| 2016-10-22 | LincolnvEastleighNational League · England | 0–0 | National League · England |
| 2016-10-22 | Talleres CordobavDefensa y JusticiaLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2016-10-22 | NumanciavSevilla BLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2016-10-22 | FreiburgvAugsburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2016-10-22 | Slask WroclawvCracoviaEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2016-10-22 | Forest GreenvGuiseleyNational League · England | 3–0 | National League · England |
| 2016-10-22 | FeirensevSetubalPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2016-10-22 | Nott'm ForestvCardiffChampionship · England | 1–2 | Championship · England |
| 2016-10-22 | Albirex NiigatavUrawa RedsJ1 League · Japan | 1–2 | J1 League · Japan |
| 2016-10-22 | Akhmat GroznyvRubin KazanPremier League · Russia | 3–1 | Premier League · Russia |
| 2016-10-22 | SpalvCarpiSerie B · Italy | 3–1 | Serie B · Italy |
| 2016-10-22 | HullvStokePremier League · England | 0–2 | Premier League · England |