| 2010-09-25 | WesterlovStandardPro League · Belgium | 1–2 | Pro League · Belgium |
| 2010-09-25 | PartickvDunfermlineChampionship · Scotland | 0–2 | Championship · Scotland |
| 2010-09-25 | BlackpoolvBlackburnPremier League · England | 1–2 | Premier League · England |
| 2010-09-25 | PortogruarovAscoliSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-09-25 | ScunthorpevIpswichChampionship · England | 1–1 | Championship · England |
| 2010-09-25 | HartlepoolvWalsallLeague One · England | 2–1 | League One · England |
| 2010-09-25 | StranraervArbroathLeague Two · Scotland | 4–1 | League Two · Scotland |
| 2010-09-25 | HeartsvMotherwellPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2010-09-25 | QPRvDoncasterChampionship · England | 3–0 | Championship · England |
| 2010-09-25 | MansfieldvEastbourne BoroughNational League · England | 4–0 | National League · England |
| 2010-09-25 | Sheffield WedsvSouthamptonLeague One · England | 0–1 | League One · England |
| 2010-09-25 | Dundee UnitedvSt JohnstonePremiership · Scotland | 1–0 | Premiership · Scotland |
| 2010-09-25 | YeovilvExeterLeague One · England | 1–3 | League One · England |
| 2010-09-25 | LyonvSt EtienneLigue 1 · France | 0–1 | Ligue 1 · France |
| 2010-09-25 | BurnleyvBristol CityChampionship · England | 0–0 | Championship · England |
| 2010-09-25 | PadovavAlbinoleffeSerie B · Italy | 2–0 | Serie B · Italy |
| 2010-09-25 | NorthamptonvBradfordLeague Two · England | 2–0 | League Two · England |
| 2010-09-25 | HamiltonvKilmarnockPremiership · Scotland | 2–2 | Premiership · Scotland |
| 2010-09-25 | AuxerrevNancyLigue 1 · France | 2–2 | Ligue 1 · France |
| 2010-09-25 | BielefeldvErzgebirge Aue2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2010-09-25 | LincolnvStevenageLeague Two · England | 0–1 | League Two · England |
| 2010-09-25 | EskisehirsporvGaziantepsporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2010-09-25 | AlbacetevBetisLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2010-09-25 | GillinghamvBurtonLeague Two · England | 1–0 | League Two · England |
| 2010-09-25 | GatesheadvLutonNational League · England | 1–0 | National League · England |
| 2010-09-25 | CelticvHibernianPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2010-09-25 | Annan AthleticvQueens ParkLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2010-09-25 | VicenzavCittadellaSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-09-25 | DumbartonvBrechinLeague One · Scotland | 1–3 | League One · Scotland |
| 2010-09-25 | MontrosevClydeLeague Two · Scotland | 8–1 | League Two · Scotland |
| 2010-09-25 | MarseillevSochauxLigue 1 · France | 2–1 | Ligue 1 · France |
| 2010-09-25 | FulhamvEvertonPremier League · England | 0–0 | Premier League · England |
| 2010-09-25 | OlympiakosvAsteras TripolisSuper League · Greece | 3–0 | Super League · Greece |
| 2010-09-25 | PeterheadvAlloaLeague One · Scotland | 1–0 | League One · Scotland |
| 2010-09-25 | CardiffvMillwallChampionship · England | 2–1 | Championship · England |
| 2010-09-25 | DerbyvCrystal PalaceChampionship · England | 5–0 | Championship · England |
| 2010-09-25 | AltrinchamvGrimsbyNational League · England | 2–2 | National League · England |
| 2010-09-25 | PSV EindhovenvGroningenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2010-09-25 | RotherhamvChesterfieldLeague Two · England | 1–0 | League Two · England |
| 2010-09-25 | HeerenveenvRodaEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2010-09-25 | MorecambevBarnetLeague Two · England | 2–2 | League Two · England |
| 2010-09-25 | NorwichvHullChampionship · England | 0–2 | Championship · England |
| 2010-09-25 | AyrvStenhousemuirLeague One · Scotland | 2–0 | League One · Scotland |
| 2010-09-25 | CrewevOxfordLeague Two · England | 1–1 | League Two · England |
| 2010-09-25 | MortonvRoss CountyChampionship · Scotland | 0–0 | Championship · Scotland |
| 2010-09-25 | CharltonvDag and RedLeague One · England | 2–2 | League One · England |
| 2010-09-25 | CaenvBordeauxLigue 1 · France | 0–0 | Ligue 1 · France |
| 2010-09-25 | AtromitosvPanserraikosSuper League · Greece | 2–1 | Super League · Greece |
| 2010-09-25 | HerefordvSouthendLeague Two · England | 1–3 | League Two · England |
| 2010-09-25 | MontpelliervArlesLigue 1 · France | 3–1 | Ligue 1 · France |