| 2016-10-22 | KerkyravAsteras TripolisSuper League · Greece | 2–0 | Super League · Greece |
| 2016-10-22 | FC TokyovKashima AntlersJ1 League · Japan | 2–1 | J1 League · Japan |
| 2016-10-22 | AngersvToulouseLigue 1 · France | 0–0 | Ligue 1 · France |
| 2016-10-22 | TemperleyvIndependienteLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2016-10-22 | ChesterfieldvScunthorpeLeague One · England | 0–3 | League One · England |
| 2016-10-22 | ElchevCordobaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2016-10-22 | DarmstadtvWolfsburgBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2016-10-22 | PortsmouthvNotts CountyLeague Two · England | 1–2 | League Two · England |
| 2016-10-22 | Milton Keynes DonsvSouthendLeague One · England | 0–3 | League One · England |
| 2016-10-22 | NorwichvPrestonChampionship · England | 0–1 | Championship · England |
| 2016-10-22 | LiverpoolvWest BromPremier League · England | 2–1 | Premier League · England |
| 2016-10-22 | MaidstonevGatesheadNational League · England | 0–2 | National League · England |
| 2016-10-22 | BradfordvSheffield UnitedLeague One · England | 3–3 | League One · England |
| 2016-10-22 | StabaekvSarpsborg 08Eliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2016-10-22 | ShrewsburyvNorthamptonLeague One · England | 2–4 | League One · England |
| 2016-10-22 | UfavFK RostovPremier League · Russia | 0–0 | Premier League · Russia |
| 2016-10-22 | Wisla PlockvLecznaEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2016-10-22 | BarivTrapaniSerie B · Italy | 3–0 | Serie B · Italy |
| 2016-10-22 | TomskvFK Anzi MakhackalaPremier League · Russia | 0–3 | Premier League · Russia |
| 2016-10-22 | BeneventovPerugiaSerie B · Italy | 0–0 | Serie B · Italy |
| 2016-10-22 | GetafevHuescaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2016-10-22 | Cobh RamblersvDroghedaPremier Division · Ireland | 0–2 | Premier Division · Ireland |
| 2016-10-22 | SwindonvWalsallLeague One · England | 0–2 | League One · England |
| 2016-10-22 | LyngbyvSonderjyskeSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2016-10-22 | DijonvLorientLigue 1 · France | 1–0 | Ligue 1 · France |
| 2016-10-22 | Vegalta SendaivVissel KobeJ1 League · Japan | 3–0 | J1 League · Japan |
| 2016-10-22 | Reus DeportiuvLugoLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2016-10-22 | Bayern MunichvM'gladbachBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2016-10-22 | AlanyasporvBursasporSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2016-10-22 | Club TijuanavChiapasLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2016-10-22 | Beijing GuoanvGuangzhou R&FSuper League · China | 3–1 | Super League · China |
| 2016-10-22 | LivingstonvAlloaLeague One · Scotland | 3–1 | League One · Scotland |
| 2016-10-22 | WrexhamvBromleyNational League · England | 2–1 | National League · England |
| 2016-10-22 | West HamvSunderlandPremier League · England | 1–0 | Premier League · England |
| 2016-10-22 | LensvReimsLigue 2 · France | 1–1 | Ligue 2 · France |
| 2016-10-22 | Boreham WoodvNorth FerribyNational League · England | 1–0 | National League · England |
| 2016-10-22 | PeterborovAFC WimbledonLeague One · England | 0–1 | League One · England |
| 2016-10-22 | Akhisar BelediyesporvAdanasporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2016-10-22 | ColchestervMorecambeLeague Two · England | 2–2 | League Two · England |
| 2016-10-22 | GrimsbyvCheltenhamLeague Two · England | 0–1 | League Two · England |
| 2016-10-22 | HerthavFC KolnBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2016-10-22 | RodavDen HaagEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2016-10-22 | SolihullvTranmereNational League · England | 0–3 | National League · England |
| 2016-10-22 | CrewevYeovilLeague Two · England | 0–1 | League Two · England |
| 2016-10-22 | Willem IIvUtrechtEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2016-10-22 | BurnleyvEvertonPremier League · England | 2–1 | Premier League · England |
| 2016-10-22 | Albion RvsvPeterheadLeague One · Scotland | 0–1 | League One · Scotland |
| 2016-10-22 | Nagoya GrampusvIwataJ1 League · Japan | 1–1 | J1 League · Japan |
| 2016-10-22 | OldhamvBristol RvsLeague One · England | 0–2 | League One · England |
| 2016-10-22 | WolvesvLeedsChampionship · England | 0–1 | Championship · England |