| 2010-09-25 | CrotonevSassuoloSerie B · Italy | 2–0 | Serie B · Italy |
| 2010-09-25 | TorquayvMacclesfieldLeague Two · England | 1–3 | League Two · England |
| 2010-09-25 | LiverpoolvSunderlandPremier League · England | 2–2 | Premier League · England |
| 2010-09-25 | Cercle BruggevKortrijkPro League · Belgium | 2–1 | Pro League · Belgium |
| 2010-09-25 | StuttgartvLeverkusenBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2010-09-25 | Sp GijonvValenciaLa Liga · Spain | 0–2 | La Liga · Spain |
| 2010-09-25 | Hayes & YeadingvBarrowNational League · England | 2–0 | National League · England |
| 2010-09-25 | Werder BremenvHamburgBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2010-09-25 | LeedsvSheffield UnitedChampionship · England | 1–0 | Championship · England |
| 2010-09-25 | CharleroivLiersePro League · Belgium | 0–1 | Pro League · Belgium |
| 2010-09-25 | Bayern MunichvMainzBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2010-09-25 | St MirrenvInverness CPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2010-09-25 | Las PalmasvGranadaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2010-09-25 | CheltenhamvBuryLeague Two · England | 0–2 | League Two · England |
| 2010-09-25 | CoventryvPrestonChampionship · England | 1–2 | Championship · England |
| 2010-09-25 | BesiktasvAntalyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2010-09-25 | VallecanovHuescaLa Liga 2 · Spain | 4–0 | La Liga 2 · Spain |
| 2010-09-25 | RomavInterSerie A · Italy | 1–0 | Serie A · Italy |
| 2010-09-25 | CartagenavCordobaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2010-09-25 | AcademicavGuimaraesPrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2010-09-25 | Nott'm ForestvSwanseaChampionship · England | 3–1 | Championship · England |
| 2010-09-25 | Den HaagvHeraclesEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2010-09-25 | GenkvWaregemPro League · Belgium | 3–0 | Pro League · Belgium |
| 2010-09-25 | StirlingvQueen of SthChampionship · Scotland | 0–0 | Championship · Scotland |
| 2010-09-25 | CambridgevNewport CountyNational League · England | 0–1 | National League · England |
| 2010-09-25 | RochdalevPlymouthLeague One · England | 1–1 | League One · England |
| 2010-09-25 | TamworthvYorkNational League · England | 1–3 | National League · England |
| 2010-09-25 | LivingstonvEast FifeLeague One · Scotland | 1–1 | League One · Scotland |
| 2010-09-25 | FrosinonevVareseSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-09-25 | AZ AlkmaarvUtrechtEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2010-09-25 | Ath BilbaovBarcelonaLa Liga · Spain | 1–3 | La Liga · Spain |
| 2010-09-25 | Fleetwood TownvBath CityNational League · England | 2–1 | National League · England |
| 2010-09-25 | ColchestervTranmereLeague One · England | 3–1 | League One · England |
| 2010-09-25 | MilanvGenoaSerie A · Italy | 1–0 | Serie A · Italy |
| 2010-09-25 | GenclerbirligivAnkaragucuSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2010-09-25 | PortovOlhanensePrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2010-09-25 | LevantevReal MadridLa Liga · Spain | 0–0 | La Liga · Spain |
| 2010-09-25 | ForfarvAirdrie UtdLeague One · Scotland | 1–2 | League One · Scotland |
| 2010-09-25 |  French Guianav Saint Pierre and MiquelonCoupe de l'Outre-Mer | 7–0 | Coupe de l'Outre-Mer |
| 2010-09-25 | NicevRennesLigue 1 · France | 1–2 | Ligue 1 · France |
| 2010-09-25 | ReadingvBarnsleyChampionship · England | 3–0 | Championship · England |
| 2010-09-25 | Bristol RvsvNotts CountyLeague One · England | 2–1 | League One · England |
| 2010-09-25 | TwentevAjaxEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2010-09-25 | ArsenalvWest BromPremier League · England | 2–3 | Premier League · England |
| 2010-09-25 | EmpolivGrossetoSerie B · Italy | 1–0 | Serie B · Italy |
| 2010-09-25 | WrexhamvHistonNational League · England | 4–0 | National League · England |
| 2010-09-25 |  Mayottev RéunionCoupe de l'Outre-Mer | 1–2 | Coupe de l'Outre-Mer |
| 2010-09-25 | MaritimovBenficaPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2010-09-25 | WatfordvMiddlesbroughChampionship · England | 3–1 | Championship · England |
| 2010-09-25 |  Iraqv YemenWAFF Championship | 2–1 | WAFF Championship |