| 2008-10-04 | LeverkusenvHerthaBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2008-10-04 | TubizevDenderPro League · Belgium | 2–1 | Pro League · Belgium |
| 2008-10-04 | NicevSochauxLigue 1 · France | 1–1 | Ligue 1 · France |
| 2008-10-04 | St JohnstonevAirdrie UtdChampionship · Scotland | 3–1 | Championship · Scotland |
| 2008-10-04 | Queen of SthvLivingstonChampionship · Scotland | 6–1 | Championship · Scotland |
| 2008-10-04 | MorecambevChesterfieldLeague Two · England | 2–2 | League Two · England |
| 2008-10-04 | Leyton OrientvScunthorpeLeague One · England | 2–2 | League One · England |
| 2008-10-04 | ColchestervBristol RvsLeague One · England | 0–1 | League One · England |
| 2008-10-04 | AnkarasporvSivassporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2008-10-04 | AyrvPeterheadLeague One · Scotland | 2–0 | League One · Scotland |
| 2008-10-04 | WiganvMiddlesbroughPremier League · England | 0–1 | Premier League · England |
| 2008-10-04 | RotherhamvGrimsbyLeague Two · England | 4–1 | League Two · England |
| 2008-10-04 | AldershotvBuryLeague Two · England | 3–3 | League Two · England |
| 2008-10-04 | HistonvSalisburyNational League · England | 2–0 | National League · England |
| 2008-10-04 | West BromvFulhamPremier League · England | 1–0 | Premier League · England |
| 2008-10-04 | CoventryvSouthamptonChampionship · England | 4–1 | Championship · England |
| 2008-10-04 | LorientvBordeauxLigue 1 · France | 1–2 | Ligue 1 · France |
| 2008-10-04 | AvellinovAscoliSerie B · Italy | 0–2 | Serie B · Italy |
| 2008-10-04 | Sevilla BvSociedadLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2008-10-04 | PlymouthvSheffield WedsChampionship · England | 4–0 | Championship · England |
| 2008-10-04 | StenhousemuirvForfarLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2008-10-04 | Le HavrevLe MansLigue 1 · France | 1–2 | Ligue 1 · France |
| 2008-10-04 | BurtonvCrawley TownNational League · England | 2–1 | National League · England |
| 2008-10-04 | ParmavModenaSerie B · Italy | 0–0 | Serie B · Italy |
| 2008-10-04 | IntervBolognaSerie A · Italy | 2–1 | Serie A · Italy |
| 2008-10-04 | TorquayvStevenageNational League · England | 3–0 | National League · England |
| 2008-10-04 | Nott'm ForestvCrystal PalaceChampionship · England | 0–2 | Championship · England |
| 2008-10-04 | HoffenheimvEin FrankfurtBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2008-10-04 | CarlislevTranmereLeague One · England | 1–2 | League One · England |
| 2008-10-04 | LaziovLecceSerie A · Italy | 1–1 | Serie A · Italy |
| 2008-10-04 | Forest GreenvWrexhamNational League · England | 2–3 | National League · England |
| 2008-10-04 | RochdalevDag and RedLeague Two · England | 0–2 | League Two · England |
| 2008-10-04 | CrewevNorthamptonLeague One · England | 1–3 | League One · England |
| 2008-10-04 | CelticvHamiltonPremiership · Scotland | 4–0 | Premiership · Scotland |
| 2008-10-04 | WeymouthvEastbourne BoroughNational League · England | 3–2 | National League · England |
| 2008-10-04 | BrechinvAlloaLeague One · Scotland | 3–1 | League One · Scotland |
| 2008-10-04 | NavalvBelenensesPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2008-10-04 | ArisvIraklisSuper League · Greece | 1–0 | Super League · Greece |
| 2008-10-04 | Dundee UnitedvInverness CPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2008-10-04 | AberdeenvHibernianPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2008-10-04 | BarcelonavAth MadridLa Liga · Spain | 6–1 | La Liga · Spain |
| 2008-10-04 | BerwickvElginLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2008-10-04 | ErgotelisvPAOKSuper League · Greece | 0–0 | Super League · Greece |
| 2008-10-04 | OxfordvRushden & DNational League · England | 2–1 | National League · England |
| 2008-10-04 | VillarrealvBetisLa Liga · Spain | 2–1 | La Liga · Spain |
| 2008-10-04 | Ross CountyvMortonChampionship · Scotland | 3–0 | Championship · Scotland |
| 2008-10-04 | VitessevWillem IIEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2008-10-04 | BergenvCharleroiPro League · Belgium | 1–1 | Pro League · Belgium |
| 2008-10-04 | AnconavRiminiSerie B · Italy | 5–0 | Serie B · Italy |
| 2008-10-04 | YorkvCambridgeNational League · England | 0–0 | National League · England |