| 2000-09-24 | MurciavAlbaceteLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2000-09-24 | SalamancavLeganesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2000-09-24 | IraklisvPanahaikiSuper League · Greece | 2–0 | Super League · Greece |
| 2000-09-24 | NumanciavValenciaLa Liga · Spain | 0–3 | La Liga · Spain |
| 2000-09-24 | DenizlisporvRizesporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2000-09-24 | TrabzonsporvGenclerbirligiSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2000-09-24 | Hansa RostockvKaiserslauternBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2000-09-24 | YianninavPAOKSuper League · Greece | 1–3 | Super League · Greece |
| 2000-09-24 | AvesvFarensePrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2000-09-24 | OsasunavVallecanoLa Liga · Spain | 2–2 | La Liga · Spain |
| 2000-09-24 | OberhausenvChemnitz2. Bundesliga · Germany | 4–1 | 2. Bundesliga · Germany |
| 2000-09-24 | VillarrealvOviedoLa Liga · Spain | 1–0 | La Liga · Spain |
| 2000-09-24 | WaalwijkvNijmegenEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2000-09-24 | PescaravMonzaSerie B · Italy | 1–2 | Serie B · Italy |
| 2000-09-24 | Sp BragavAlvercaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2000-09-24 | ErzurumsporvKocaelisporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2000-09-24 | BadajozvBetisLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2000-09-24 | ArisvPaniliakosSuper League · Greece | 1–0 | Super League · Greece |
| 2000-09-23 | CaenvNiceLigue 2 · France | 1–0 | Ligue 2 · France |
| 2000-09-23 | Werder BremenvEin FrankfurtBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2000-09-23 | MotherwellvRangersPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2000-09-23 | BrechinvEast FifeLeague Two · Scotland | 3–1 | League Two · Scotland |
| 2000-09-23 | TenerifevLevanteLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2000-09-23 | U.Las PalmasvRecreativoLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2000-09-23 | AyrvClydeChampionship · Scotland | 2–1 | Championship · Scotland |
| 2000-09-23 | LiverpoolvSunderlandPremier League · England | 1–1 | Premier League · England |
| 2000-09-23 | CharleroivGentPro League · Belgium | 4–3 | Pro League · Belgium |
| 2000-09-23 | WesterlovLokerenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2000-09-23 | StenhousemuirvBerwickLeague One · Scotland | 2–0 | League One · Scotland |
| 2000-09-23 | MansfieldvHartlepoolLeague Two · England | 4–3 | League Two · England |
| 2000-09-23 | BarcelonavSantanderLa Liga · Spain | 3–1 | La Liga · Spain |
| 2000-09-23 | Gil VicentevSp LisbonPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2000-09-23 | MillwallvOxfordLeague One · England | 5–0 | League One · England |
| 2000-09-23 | NiortvCreteilLigue 2 · France | 0–0 | Ligue 2 · France |
| 2000-09-23 | TorquayvHalifaxLeague Two · England | 1–2 | League Two · England |
| 2000-09-23 | St PaulivBielefeld2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2000-09-23 | BoavistavBenficaPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2000-09-23 | BlackpoolvChesterfieldLeague Two · England | 1–3 | League Two · England |
| 2000-09-23 | Ross CountyvFalkirkChampionship · Scotland | 0–2 | Championship · Scotland |
| 2000-09-23 | CoventryvWest HamPremier League · England | 0–3 | Premier League · England |
| 2000-09-23 | For SittardvVitesseEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2000-09-23 | BarnetvHullLeague Two · England | 1–1 | League Two · England |
| 2000-09-23 | FulhamvGillinghamChampionship · England | 3–0 | Championship · England |
| 2000-09-23 | SouthendvScunthorpeLeague Two · England | 1–0 | League Two · England |
| 2000-09-23 | Leyton OrientvLincolnLeague Two · England | 1–0 | League Two · England |
| 2000-09-23 | AirdrievLivingstonChampionship · Scotland | 1–2 | Championship · Scotland |
| 2000-09-23 | Queen of SthvForfarLeague One · Scotland | 0–1 | League One · Scotland |
| 2000-09-23 | SociedadvLa CorunaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2000-09-23 | MannheimvReutlingen2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2000-09-23 | CottbusvLeverkusenBundesliga · Germany | 1–2 | Bundesliga · Germany |