| 2021-10-29 | Shamrock RoversvFinn HarpsPremier Division · Ireland | 3–0 | Premier Division · Ireland |
| 2021-10-29 | CracoviavRadomiak RadomEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-10-29 | Racing ClubvDefensa y JusticiaLiga Profesional · Argentina | 1–2 | Liga Profesional · Argentina |
| 2021-10-29 | DundalkvWaterfordPremier Division · Ireland | 1–0 | Premier Division · Ireland |
| 2021-10-29 | Paris SGvLilleLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-10-29 | Sligo RoversvDroghedaPremier Division · Ireland | 2–0 | Premier Division · Ireland |
| 2021-10-29 | Stal MielecvLech PoznanEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2021-10-29 | FC BotosanivFarul ConstantaSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-10-29 | DarmstadtvNurnberg2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2021-10-29 | Sociedad BvLas PalmasLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-10-29 | LongfordvSt. PatricksPremier Division · Ireland | 1–4 | Premier Division · Ireland |
| 2021-10-29 | Derry CityvBohemiansPremier Division · Ireland | 1–1 | Premier Division · Ireland |
| 2021-10-29 | TrabzonsporvRizesporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-10-29 | OostendevMechelenPro League · Belgium | 2–4 | Pro League · Belgium |
| 2021-10-29 | HeidenheimvSchalke 042. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2021-10-29 | AroucavTondelaPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-10-29 | AtlasvClub TijuanaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-10-29 | QPRvNott'm ForestChampionship · England | 1–1 | Championship · England |
| 2021-10-29 | HoffenheimvHerthaBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-10-28 | CremonesevPisaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-10-28 | NapolivBolognaSerie A · Italy | 3–0 | Serie A · Italy |
| 2021-10-28 | BrannvVikingEliteserien · Norway | 0–2 | Eliteserien · Norway |
| 2021-10-28 | AscolivSpalSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-10-28 | New York CityvChicago FireMLS · United States | 1–0 | MLS · United States |
| 2021-10-28 | Toronto FCvPhiladelphia UnionMLS · United States | 2–2 | MLS · United States |
| 2021-10-28 | HalmstadvOrebroAllsvenskan · Sweden | 1–1 | Allsvenskan · Sweden |
| 2021-10-28 | DegerforsvElfsborgAllsvenskan · Sweden | 1–2 | Allsvenskan · Sweden |
| 2021-10-28 | GoteborgvDjurgardenAllsvenskan · Sweden | 3–0 | Allsvenskan · Sweden |
| 2021-10-28 | BresciavLecceSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-10-28 | CeltavSociedadLa Liga · Spain | 0–2 | La Liga · Spain |
| 2021-10-28 | FC CincinnativNashville SCMLS · United States | 3–6 | MLS · United States |
| 2021-10-28 | CrotonevBeneventoSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-10-28 | DC UnitedvNew York Red BullsMLS · United States | 1–0 | MLS · United States |
| 2021-10-28 | Atlanta UtdvInter MiamiMLS · United States | 2–1 | MLS · United States |
| 2021-10-28 | Columbus CrewvOrlando CityMLS · United States | 3–2 | MLS · United States |
| 2021-10-28 | Vancouver WhitecapsvMinnesota UnitedMLS · United States | 2–1 | MLS · United States |
| 2021-10-28 | AlessandriavFrosinoneSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-10-28 | PerugiavRegginaSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-10-28 | Sarpsborg 08vValerengaEliteserien · Norway | 2–1 | Eliteserien · Norway |
| 2021-10-28 | New England RevolutionvColorado RapidsMLS · United States | 1–0 | MLS · United States |
| 2021-10-28 | ComovPordenoneSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-10-28 | Portland TimbersvSan Jose EarthquakesMLS · United States | 2–0 | MLS · United States |
| 2021-10-28 | GranadavGetafeLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-10-28 | Sporting Kansas CityvLos Angeles GalaxyMLS · United States | 2–0 | MLS · United States |
| 2021-10-28 | CittadellavParmaSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-10-28 | FC DallasvReal Salt LakeMLS · United States | 1–2 | MLS · United States |
| 2021-10-28 | BragantinovSport RecifeSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2021-10-28 | LevantevAth MadridLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-10-28 | NorrkopingvMjallbyAllsvenskan · Sweden | 2–2 | Allsvenskan · Sweden |
| 2021-10-27 | NicevMarseilleLigue 1 · France | 1–1 | Ligue 1 · France |